| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 4,910,487 | 198,973,000 | 15.05% | ||
| 2 | FMR LLC | 4,800,472 | 194,515,000 | 14.71% | ||
| 3 | JHL Capital Group LLC | 3,265,000 | 132,298,000 | 10.01% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,936,814 | 78,480,000 | 5.94% | ||
| 5 | ORBIMED ADVISORS LLC | 1,923,500 | 77,940,000 | 5.90% | ||
| 6 | VANGUARD GROUP INC | 1,771,193 | 71,769,000 | 5.43% | ||
| 7 | MORGAN STANLEY | 1,495,124 | 60,582,000 | 4.58% | ||
| 8 | SV Health Investors, LLC | 1,103,981 | 44,734,000 | 3.38% | ||
| 9 | EAGLE ASSET MANAGEMENT INC | 1,060,922 | 42,988,000 | 3.25% | ||
| 10 | BlackRock Fund Advisors | 1,055,642 | 42,775,000 | 3.24% | ||
| 11 | STATE STREET CORP | 865,006 | 35,051,000 | 2.65% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 607,334 | 24,609,000 | 1.86% | ||
| 13 | FRANKLIN RESOURCES INC | 571,972 | 23,177,000 | 1.75% | ||
| 14 | ALPS ADVISORS INC | 53,684 | 21,753,000 | 1.65% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 377,500 | 15,296,000 | 1.16% | ||
| 16 | BALYASNY ASSET MANAGEMENT L.P. | 309,202 | 12,529,000 | 0.95% | ||
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 297,119 | 12,039,000 | 0.91% | ||
| 18 | GOLDMAN SACHS GROUP INC | 289,743 | 11,740,000 | 0.89% | ||
| 19 | Numeric Investors LLC | 272,400 | 11,038,000 | 0.83% | ||
| 20 | NORTHERN TRUST CORP | 258,038 | 10,456,000 | 0.79% | ||
| 21 | Allianz Asset Management GmbH | 243,470 | 9,866,000 | 0.75% | ||
| 22 | NORGES BANK | 218,287 | 8,845,000 | 0.67% | ||
| 23 | AXA S.A. | 217,153 | 8,799,000 | 0.67% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 200,236 | 8,113,000 | 0.61% | ||
| 25 | HIGHLAND CAPITAL MANAGEMENT LP | 172,386 | 6,985,000 | 0.53% | ||
| 26 | MARSHALL WACE, LLP | 164,447 | 6,663,000 | 0.50% | ||
| 27 | Apex Capital Management | 162,993 | 6,604,000 | 0.50% | ||
| 28 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 159,067 | 6,446,000 | 0.49% | ||
| 29 | WILLIAM HARRIS INVESTORS INC | 143,022 | 5,795,000 | 0.44% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 128,311 | 5,199,000 | 0.39% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 128,045 | 5,188,000 | 0.39% | ||
| 32 | AMUNDI ASSET MANAGEMENT US, INC. | 127,870 | 5,181,000 | 0.39% | ||
| 33 | Overbrook Management Corp | 117,807 | 4,774,000 | 0.36% | ||
| 34 | AlpInvest Partners B.V. | 111,519 | 4,519,000 | 0.34% | ||
| 35 | Bank of New York Mellon Corp | 110,523 | 4,478,000 | 0.34% | ||
| 36 | Opaleye Management Inc. | 105,000 | 4,255,000 | 0.32% | ||
| 37 | LORD, ABBETT & CO. LLC | 102,410 | 4,150,000 | 0.31% | ||
| 38 | AMERICAN CENTURY COMPANIES INC | 88,173 | 3,573,000 | 0.27% | ||
| 39 | Invesco Ltd. | 86,809 | 3,517,000 | 0.27% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 81,594 | 3,307,000 | 0.25% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,200 | 3,250,000 | 0.25% | Put | |
| 42 | BNP PARIBAS FINANCIAL MARKETS | 79,671 | 3,228,269 | 0.24% | ||
| 43 | BlackRock Investment Management, LLC | 79,645 | 3,227,000 | 0.24% | ||
| 44 | Candriam S.C.A. | 73,500 | 2,978,000 | 0.23% | ||
| 45 | IMA Advisory Services, Inc. | 66,061 | 2,623,000 | 0.20% | SH | |
| 46 | PICTET ASSET MANAGEMENT LTD | 61,600 | 2,496,000 | 0.19% | ||
| 47 | JPMORGAN CHASE & CO | 60,539 | 2,453,000 | 0.19% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,787 | 2,342,000 | 0.18% | ||
| 49 | GOLDMAN SACHS GROUP INC | 50,000 | 2,026,000 | 0.15% | Call | |
| 50 | GOLDMAN SACHS GROUP INC | 50,000 | 2,026,000 | 0.15% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
