| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 4,910,487 | 207,566,000 | 15.00% | ||
| 2 | FMR LLC | 3,696,385 | 156,246,000 | 11.29% | ||
| 3 | JHL Capital Group LLC | 3,265,000 | 138,012,000 | 9.97% | ||
| 4 | ORBIMED ADVISORS LLC | 2,094,500 | 88,535,000 | 6.40% | ||
| 5 | VANGUARD GROUP INC | 1,979,612 | 83,679,000 | 6.05% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,768,227 | 74,743,000 | 5.40% | ||
| 7 | MORGAN STANLEY | 1,537,894 | 65,007,000 | 4.70% | ||
| 8 | STATE STREET CORP | 1,078,837 | 45,601,000 | 3.30% | ||
| 9 | BlackRock Fund Advisors | 1,022,007 | 43,200,000 | 3.12% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 1,017,760 | 43,020,000 | 3.11% | ||
| 11 | Apex Capital Management | 678,284 | 28,671,000 | 2.07% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 663,813 | 28,059,000 | 2.03% | ||
| 13 | FRANKLIN RESOURCES INC | 587,702 | 24,842,000 | 1.80% | ||
| 14 | Slate Path Capital LP | 430,000 | 18,176,000 | 1.31% | ||
| 15 | Point72 Asset Management, L.P. | 414,400 | 17,517,000 | 1.27% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 362,500 | 15,323,000 | 1.11% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 357,106 | 15,095,000 | 1.09% | ||
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 306,456 | 12,954,000 | 0.94% | ||
| 19 | GOLDMAN SACHS GROUP INC | 283,546 | 11,986,000 | 0.87% | ||
| 20 | Allianz Asset Management GmbH | 275,307 | 11,637,000 | 0.84% | ||
| 21 | NORTHERN TRUST CORP | 273,211 | 11,548,000 | 0.83% | ||
| 22 | NORGES BANK | 254,064 | 10,739,000 | 0.78% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 246,229 | 10,408,000 | 0.75% | ||
| 24 | LOOMIS SAYLES & CO L P | 237,568 | 10,042,000 | 0.73% | ||
| 25 | CITADEL ADVISORS LLC | 227,133 | 9,601,000 | 0.69% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 225,073 | 9,514,000 | 0.69% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 208,212 | 8,800,000 | 0.64% | ||
| 28 | AXA S.A. | 180,920 | 7,647,000 | 0.55% | ||
| 29 | Bank of New York Mellon Corp | 142,611 | 6,027,000 | 0.44% | ||
| 30 | VOYA INVESTMENT MANAGEMENT LLC | 140,537 | 5,941,000 | 0.43% | ||
| 31 | MARSHALL WACE, LLP | 139,298 | 5,888,000 | 0.43% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 121,130 | 5,120,000 | 0.37% | ||
| 33 | Ghost Tree Capital, LLC | 120,000 | 5,072,000 | 0.37% | ||
| 34 | Overbrook Management Corp | 112,129 | 4,740,000 | 0.34% | ||
| 35 | Numeric Investors LLC | 107,144 | 4,529,000 | 0.33% | ||
| 36 | Invesco Ltd. | 101,313 | 4,283,000 | 0.31% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 100,700 | 4,257,000 | 0.31% | Call | |
| 38 | Candriam S.C.A. | 101,000 | 4,246,000 | 0.31% | ||
| 39 | UBS Group AG | 100,000 | 4,227,000 | 0.31% | Call | |
| 40 | JPMORGAN CHASE & CO | 94,795 | 4,007,000 | 0.29% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 89,611 | 3,788,000 | 0.27% | ||
| 42 | HIGHLAND CAPITAL MANAGEMENT LP | 83,861 | 3,545,000 | 0.26% | ||
| 43 | BlackRock Investment Management, LLC | 82,425 | 3,484,000 | 0.25% | ||
| 44 | Opaleye Management Inc. | 80,000 | 3,382,000 | 0.24% | ||
| 45 | GOLDMAN SACHS GROUP INC | 77,800 | 3,289,000 | 0.24% | Call | |
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 72,287 | 3,056,000 | 0.22% | ||
| 47 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 66,840 | 2,825,000 | 0.20% | ||
| 48 | US BANCORP \DE\ | 65,747 | 2,780,000 | 0.20% | ||
| 49 | IMA Advisory Services, Inc. | 66,506 | 2,771,000 | 0.20% | SH | |
| 50 | LORD, ABBETT & CO. LLC | 65,055 | 2,750,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
