| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,155,235 | 404,841,000 | 16.31% | ||
| 2 | Novo Holdings A/S | 4,910,487 | 385,621,000 | 15.53% | ||
| 3 | JHL Capital Group LLC | 3,265,000 | 256,400,000 | 10.33% | ||
| 4 | ORBIMED ADVISORS LLC | 2,011,500 | 157,963,000 | 6.36% | ||
| 5 | VANGUARD GROUP INC | 1,822,030 | 143,085,000 | 5.76% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,639,927 | 128,783,000 | 5.19% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,080,625 | 84,861,000 | 3.42% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 1,056,719 | 82,984,000 | 3.34% | ||
| 9 | BlackRock Fund Advisors | 987,102 | 77,517,000 | 3.12% | ||
| 10 | STATE STREET CORP | 706,943 | 55,514,000 | 2.24% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 649,770 | 51,026,000 | 2.06% | ||
| 12 | Apex Capital Management | 628,643 | 49,367,000 | 1.99% | ||
| 13 | FRANKLIN RESOURCES INC | 506,772 | 39,796,000 | 1.60% | ||
| 14 | MORGAN STANLEY | 464,389 | 36,468,000 | 1.47% | ||
| 15 | LORD, ABBETT & CO. LLC | 455,832 | 35,796,000 | 1.44% | ||
| 16 | GOLDMAN SACHS GROUP INC | 384,088 | 30,162,000 | 1.22% | ||
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 308,206 | 24,203,000 | 0.97% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 301,415 | 23,670,000 | 0.95% | ||
| 19 | SECTORAL ASSET MANAGEMENT INC | 288,906 | 22,688,000 | 0.91% | ||
| 20 | Allianz Asset Management GmbH | 268,270 | 21,005,000 | 0.85% | ||
| 21 | NORTHERN TRUST CORP | 266,415 | 20,922,000 | 0.84% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 220,978 | 17,353,000 | 0.70% | ||
| 23 | NORGES BANK | 218,287 | 17,142,000 | 0.69% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 210,626 | 16,539,000 | 0.67% | ||
| 25 | AXA S.A. | 183,842 | 14,437,000 | 0.58% | ||
| 26 | BALYASNY ASSET MANAGEMENT L.P. | 165,891 | 13,027,000 | 0.52% | ||
| 27 | Numeric Investors LLC | 138,944 | 10,911,000 | 0.44% | ||
| 28 | Bank of New York Mellon Corp | 134,836 | 10,590,000 | 0.43% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 123,237 | 9,678,000 | 0.39% | ||
| 30 | MARSHALL WACE, LLP | 117,964 | 9,264,000 | 0.37% | ||
| 31 | Overbrook Management Corp | 117,807 | 9,251,000 | 0.37% | ||
| 32 | Candriam S.C.A. | 112,500 | 8,835,000 | 0.36% | ||
| 33 | Opaleye Management Inc. | 105,000 | 8,246,000 | 0.33% | ||
| 34 | JPMORGAN CHASE & CO | 96,530 | 7,580,000 | 0.31% | ||
| 35 | VOYA INVESTMENT MANAGEMENT LLC | 96,512 | 7,579,000 | 0.31% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,076 | 6,917,000 | 0.28% | ||
| 37 | Invesco Ltd. | 86,192 | 6,768,000 | 0.27% | ||
| 38 | AMUNDI ASSET MANAGEMENT US, INC. | 83,168 | 6,531,000 | 0.26% | ||
| 39 | BlackRock Investment Management, LLC | 79,684 | 6,258,000 | 0.25% | ||
| 40 | PRUDENTIAL FINANCIAL INC | 75,800 | 5,953,000 | 0.24% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 70,754 | 5,556,000 | 0.22% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 70,413 | 5,530,000 | 0.22% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 69,400 | 5,450,000 | 0.22% | Call | |
| 44 | WELLS FARGO & COMPANY/MN | 67,056 | 5,265,000 | 0.21% | ||
| 45 | US BANCORP \DE\ | 65,741 | 5,163,000 | 0.21% | ||
| 46 | IMA Advisory Services, Inc. | 66,506 | 5,041,000 | 0.20% | SH | |
| 47 | Atika Capital Management LLC | 58,000 | 4,555,000 | 0.18% | ||
| 48 | GOLDMAN SACHS GROUP INC | 50,000 | 3,927,000 | 0.16% | Call | |
| 49 | GOLDMAN SACHS GROUP INC | 50,000 | 3,927,000 | 0.16% | Put | |
| 50 | ALPS ADVISORS INC | 46,054 | 3,617,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
