| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,126,072 | 238,516,000 | 16.86% | ||
| 2 | Novo Holdings A/S | 4,910,487 | 228,485,000 | 16.15% | ||
| 3 | JHL Capital Group LLC | 3,265,000 | 151,920,000 | 10.74% | ||
| 4 | SV Health Investors, LLC | 2,053,143 | 95,533,000 | 6.75% | ||
| 5 | ORBIMED ADVISORS LLC | 1,668,600 | 77,640,000 | 5.49% | ||
| 6 | Clarus Ventures, LLC | 1,554,744 | 72,342,000 | 5.11% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,400,966 | 65,187,000 | 4.61% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 1,358,305 | 63,201,000 | 4.47% | ||
| 9 | VANGUARD GROUP INC | 1,305,725 | 60,755,000 | 4.29% | ||
| 10 | MORGAN STANLEY | 987,927 | 45,968,000 | 3.25% | ||
| 11 | BlackRock Fund Advisors | 773,800 | 36,005,000 | 2.55% | ||
| 12 | STATE STREET CORP | 624,910 | 29,078,000 | 2.06% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 389,200 | 18,109,000 | 1.28% | ||
| 14 | Allianz Asset Management GmbH | 334,860 | 15,582,000 | 1.10% | ||
| 15 | FRANKLIN RESOURCES INC | 219,658 | 10,220,000 | 0.72% | ||
| 16 | GOLDMAN SACHS GROUP INC | 201,662 | 9,384,000 | 0.66% | ||
| 17 | STIFEL FINANCIAL CORP | 180,309 | 8,390,000 | 0.59% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 172,382 | 8,021,000 | 0.57% | ||
| 19 | NORTHERN TRUST CORP | 144,311 | 6,715,000 | 0.47% | ||
| 20 | Candriam S.C.A. | 136,000 | 6,330,000 | 0.45% | ||
| 21 | Apex Capital Management | 132,070 | 6,145,000 | 0.43% | ||
| 22 | Cheyne Capital Management (UK) LLP | 124,151 | 5,777,000 | 0.41% | ||
| 23 | Cupps Capital Management, LLC | 117,541 | 5,469,000 | 0.39% | ||
| 24 | AHL Partners LLP | 112,988 | 5,257,000 | 0.37% | ||
| 25 | LORD, ABBETT & CO. LLC | 108,113 | 5,030,000 | 0.36% | ||
| 26 | DEUTSCHE BANK AG\ | 107,379 | 4,995,000 | 0.35% | ||
| 27 | WILLIAM HARRIS INVESTORS INC | 106,158 | 4,939,000 | 0.35% | ||
| 28 | Opaleye Management Inc. | 105,000 | 4,886,000 | 0.35% | ||
| 29 | MANAGED ACCOUNT ADVISORS LLC | 102,031 | 4,748,000 | 0.34% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 101,706 | 4,732,000 | 0.33% | ||
| 31 | AXA S.A. | 95,764 | 4,456,000 | 0.32% | ||
| 32 | Bank of New York Mellon Corp | 94,307 | 4,389,000 | 0.31% | ||
| 33 | TWO SIGMA INVESTMENTS, LP | 93,907 | 4,369,000 | 0.31% | ||
| 34 | BARCLAYS PLC | 94,309 | 4,339,000 | 0.31% | ||
| 35 | AMERICAN CENTURY COMPANIES INC | 85,046 | 3,957,000 | 0.28% | ||
| 36 | Invesco Ltd. | 84,657 | 3,939,000 | 0.28% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 84,065 | 3,911,000 | 0.28% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 82,638 | 3,845,000 | 0.27% | ||
| 39 | IMA Advisory Services, Inc. | 67,930 | 3,161,000 | 0.22% | ||
| 40 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 63,837 | 2,970,000 | 0.21% | ||
| 41 | WELLINGTON MANAGEMENT GROUP LLP | 62,568 | 2,911,000 | 0.21% | ||
| 42 | Numeric Investors LLC | 62,500 | 2,908,000 | 0.21% | ||
| 43 | Informed Momentum Co LLC | 58,212 | 2,709,000 | 0.19% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 51,280 | 2,386,000 | 0.17% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 50,000 | 2,327,000 | 0.16% | Call | |
| 46 | BANK OF AMERICA CORP /DE/ | 50,000 | 2,327,000 | 0.16% | Put | |
| 47 | Overbrook Management Corp | 50,000 | 2,327,000 | 0.16% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,761 | 1,944,000 | 0.14% | ||
| 49 | JPMORGAN CHASE & CO | 39,325 | 1,830,000 | 0.13% | ||
| 50 | BlackRock Investment Management, LLC | 38,154 | 1,775,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
