| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 6,896,819 | 246,044,000 | 31.79% | ||
| 2 | FMR LLC | 3,073,251 | 109,838,000 | 14.19% | ||
| 3 | Clarus Ventures, LLC | 3,054,744 | 108,963,000 | 14.08% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,737,856 | 61,998,000 | 8.01% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,304,402 | 46,534,000 | 6.01% | ||
| 6 | JHL Capital Group LLC | 1,210,000 | 43,245,000 | 5.59% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 995,823 | 35,591,000 | 4.60% | ||
| 8 | VANGUARD GROUP INC | 539,414 | 19,279,000 | 2.49% | ||
| 9 | Consonance Capital Management LP | 311,287 | 11,105,000 | 1.43% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 250,000 | 8,935,000 | 1.15% | ||
| 11 | Independence Capital Asset Partners, LLC | 249,590 | 8,904,000 | 1.15% | ||
| 12 | BlackRock Fund Advisors | 235,236 | 8,392,000 | 1.08% | ||
| 13 | GOLDMAN SACHS GROUP INC | 224,750 | 8,018,000 | 1.04% | ||
| 14 | MORGAN STANLEY | 135,535 | 4,835,000 | 0.62% | ||
| 15 | STATE STREET CORP | 131,221 | 4,690,000 | 0.61% | ||
| 16 | NORTHERN TRUST CORP | 113,299 | 4,042,000 | 0.52% | ||
| 17 | FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 105,630 | 3,768,000 | 0.49% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 97,103 | 3,464,000 | 0.45% | ||
| 19 | MANAGED ACCOUNT ADVISORS LLC | 73,535 | 2,623,000 | 0.34% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,500 | 2,448,000 | 0.32% | Put | |
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 62,641 | 2,238,000 | 0.29% | ||
| 22 | BLACKROCK ADVISORS LLC | 54,177 | 1,933,000 | 0.25% | ||
| 23 | GOLDMAN SACHS GROUP INC | 50,000 | 1,784,000 | 0.23% | Put | |
| 24 | TCW GROUP INC | 48,565 | 1,736,000 | 0.22% | ||
| 25 | Bank of New York Mellon Corp | 44,223 | 1,578,000 | 0.20% | ||
| 26 | Pentwater Capital Management LP | 40,000 | 1,427,000 | 0.18% | ||
| 27 | BAKER BROS. ADVISORS LP | 36,776 | 1,314,000 | 0.17% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 35,354 | 1,264,000 | 0.16% | ||
| 29 | Absolute Return Capital, LLC | 27,357 | 976,000 | 0.13% | ||
| 30 | BlackRock Investment Management, LLC | 26,876 | 959,000 | 0.12% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,607 | 951,000 | 0.12% | ||
| 32 | WELLS FARGO & COMPANY/MN | 26,315 | 938,000 | 0.12% | ||
| 33 | Zweig-DiMenna Associates LLC | 25,000 | 892,000 | 0.12% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,729 | 777,000 | 0.10% | ||
| 35 | JPMORGAN CHASE & CO | 20,205 | 720,000 | 0.09% | ||
| 36 | TD ASSET MANAGEMENT INC | 20,100 | 718,000 | 0.09% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 20,100 | 717,000 | 0.09% | Put | |
| 38 | Redmile Group, LLC | 19,374 | 692,000 | 0.09% | ||
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 19,000 | 679,000 | 0.09% | ||
| 40 | State of New Jersey Common Pension Fund A | 17,500 | 625,000 | 0.08% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,100 | 611,000 | 0.08% | ||
| 42 | SABBY MANAGEMENT, LLC | 15,944 | 570,000 | 0.07% | ||
| 43 | FEDERATED HERMES, INC. | 15,000 | 536,000 | 0.07% | ||
| 44 | TEACHERS ADVISORS, LLC | 13,890 | 496,000 | 0.06% | ||
| 45 | ROYAL BANK OF CANADA | 13,200 | 471,000 | 0.06% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,700 | 418,000 | 0.05% | Call | |
| 47 | STIFEL FINANCIAL CORP | 10,922 | 390,000 | 0.05% | ||
| 48 | RAYMOND JAMES & ASSOCIATES | 10,915 | 389,000 | 0.05% | ||
| 49 | TWO SIGMA INVESTMENTS, LP | 10,400 | 372,000 | 0.05% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 9,736 | 348,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
