| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 2,730,765 | 22,993,000 | 21.07% | ||
| 2 | Abingworth LLP | 2,199,012 | 18,450,000 | 16.91% | ||
| 3 | CANNELL CAPITAL LLC | 1,139,571 | 9,595,000 | 8.79% | ||
| 4 | Park West Asset Management LLC | 1,093,385 | 9,206,000 | 8.44% | ||
| 5 | GILDER GAGNON HOWE & CO LLC | 817,609 | 6,884,000 | 6.31% | ||
| 6 | GOLDMAN SACHS GROUP INC | 783,978 | 6,601,000 | 6.05% | ||
| 7 | AMERIPRISE FINANCIAL INC | 659,859 | 5,555,000 | 5.09% | ||
| 8 | VANGUARD GROUP INC | 530,765 | 4,469,000 | 4.10% | ||
| 9 | ORBIMED ADVISORS LLC | 522,257 | 4,397,000 | 4.03% | ||
| 10 | SCHRODER INVESTMENT MANAGEMENT GROUP | 417,733 | 3,442,000 | 3.15% | ||
| 11 | ROYAL BANK OF CANADA | 400,000 | 3,368,000 | 3.09% | Call | |
| 12 | BAMCO INC /NY/ | 225,317 | 1,897,000 | 1.74% | ||
| 13 | PRELUDE CAPITAL MANAGEMENT, LLC | 173,652 | 1,462,000 | 1.34% | ||
| 14 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 155,200 | 1,307,000 | 1.20% | ||
| 15 | BlackRock Finance, Inc. | 152,934 | 1,288,000 | 1.18% | ||
| 16 | MORGAN STANLEY | 128,358 | 1,081,000 | 0.99% | ||
| 17 | Parallax Volatility Advisers, L.P. | 100,000 | 842,000 | 0.77% | Put | |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,889 | 765,000 | 0.70% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 86,792 | 730,000 | 0.67% | ||
| 20 | Jefferies Group LLC | 85,900 | 723,000 | 0.66% | Put | |
| 21 | MILLENNIUM MANAGEMENT LLC | 78,553 | 661,000 | 0.61% | ||
| 22 | Jefferies Group LLC | 78,417 | 660,000 | 0.60% | ||
| 23 | Bank of New York Mellon Corp | 51,760 | 436,000 | 0.40% | ||
| 24 | Parallax Volatility Advisers, L.P. | 39,589 | 333,000 | 0.31% | ||
| 25 | BLAIR WILLIAM & CO/IL | 30,758 | 299,000 | 0.27% | ||
| 26 | NORTHERN TRUST CORP | 27,161 | 229,000 | 0.21% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 26,600 | 224,000 | 0.21% | ||
| 28 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 23,496 | 198,000 | 0.18% | ||
| 29 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 16,410 | 138,000 | 0.13% | ||
| 30 | DIMENSIONAL FUND ADVISORS LP | 15,126 | 127,000 | 0.12% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,800 | 125,000 | 0.11% | Put | |
| 32 | BARCLAYS PLC | 14,379 | 121,000 | 0.11% | ||
| 33 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 13,967 | 117,000 | 0.11% | ||
| 34 | WELLS FARGO & COMPANY/MN | 12,871 | 108,000 | 0.10% | ||
| 35 | PEAK6 Group LLC | 11,265 | 95,000 | 0.09% | ||
| 36 | Brandywine Global Investment Management, LLC | 9,630 | 82,000 | 0.08% | ||
| 37 | CITIGROUP INC | 5,990 | 50,000 | 0.05% | ||
| 38 | Nationwide Fund Advisors | 3,042 | 26,000 | 0.02% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 1,300 | 11,000 | 0.01% | ||
| 40 | BANK OF MONTREAL /CAN/ | 1,000 | 8,000 | 0.01% | ||
| 41 | Tower Research Capital LLC (TRC) | 514 | 4,000 | 0.00% | ||
| 42 | WFG Advisors, LP | 405 | 3,000 | 0.00% | ||
| 43 | DEUTSCHE BANK AG\ | 400 | 3,000 | 0.00% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 131 | 1,000 | 0.00% | ||
| 45 | BNP PARIBAS FINANCIAL MARKETS | 8 | 67 | 0.00% | ||
| 46 | ROYAL BANK OF CANADA | 17 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
