| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Woodford Investment Management Ltd | 11,400,424 | 616,991,000 | 26.64% | ||
| 2 | FMR LLC | 5,699,234 | 308,443,000 | 13.32% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,422,265 | 239,333,000 | 10.34% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,272,862 | 177,126,000 | 7.65% | ||
| 5 | BlackRock Finance, Inc. | 2,947,512 | 159,519,000 | 6.89% | ||
| 6 | Capital World Investors | 1,323,114 | 71,607,000 | 3.09% | ||
| 7 | STATE STREET CORP | 1,181,365 | 63,932,000 | 2.76% | ||
| 8 | Palo Alto Investors LP | 1,073,955 | 58,122,000 | 2.51% | ||
| 9 | ALLIANCEBERNSTEIN L.P. | 895,759 | 48,478,000 | 2.09% | ||
| 10 | VANGUARD GROUP INC | 713,084 | 38,592,000 | 1.67% | ||
| 11 | WESTFIELD CAPITAL MANAGEMENT CO LP | 684,160 | 37,027,000 | 1.60% | ||
| 12 | Redmile Group, LLC | 509,698 | 27,585,000 | 1.19% | ||
| 13 | JENNISON ASSOCIATES LLC | 411,903 | 22,292,000 | 0.96% | ||
| 14 | OAK RIDGE INVESTMENTS LLC | 405,376 | 21,939,000 | 0.95% | ||
| 15 | NORTHERN TRUST CORP | 402,811 | 21,801,000 | 0.94% | ||
| 16 | PINNACLE ASSOCIATES LTD | 369,333 | 19,988,000 | 0.86% | ||
| 17 | BB BIOTECH AG | 350,000 | 18,942,000 | 0.82% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 338,650 | 18,327,000 | 0.79% | ||
| 19 | LOOMIS SAYLES & CO L P | 334,914 | 18,125,000 | 0.78% | ||
| 20 | NORGES BANK | 310,957 | 16,829,000 | 0.73% | ||
| 21 | Rock Springs Capital Management LP | 309,500 | 16,750,000 | 0.72% | ||
| 22 | GOLDMAN SACHS GROUP INC | 306,197 | 16,571,000 | 0.72% | ||
| 23 | WELLS FARGO & COMPANY/MN | 279,015 | 15,099,000 | 0.65% | ||
| 24 | PointState Capital LP | 272,500 | 14,748,000 | 0.64% | ||
| 25 | Invesco Ltd. | 256,037 | 13,858,000 | 0.60% | ||
| 26 | CITADEL ADVISORS LLC | 243,642 | 13,186,000 | 0.57% | ||
| 27 | VOYA INVESTMENT MANAGEMENT LLC | 241,547 | 13,073,000 | 0.56% | ||
| 28 | Hood River Capital Management LLC | 194,074 | 10,503,000 | 0.45% | ||
| 29 | Bank of New York Mellon Corp | 185,462 | 10,037,000 | 0.43% | ||
| 30 | OppenheimerFunds, Inc. | 168,506 | 9,120,000 | 0.39% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 163,681 | 8,859,000 | 0.38% | ||
| 32 | SECTORAL ASSET MANAGEMENT INC | 151,046 | 8,175,000 | 0.35% | ||
| 33 | AXA S.A. | 146,477 | 7,927,000 | 0.34% | ||
| 34 | CREDIT SUISSE AG/ | 124,909 | 6,759,000 | 0.29% | ||
| 35 | DEUTSCHE BANK AG\ | 121,518 | 6,575,000 | 0.28% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 120,603 | 6,527,000 | 0.28% | ||
| 37 | EVENTIDE ASSET MANAGEMENT, LLC | 120,000 | 6,494,000 | 0.28% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 109,000 | 5,899,000 | 0.25% | Put | |
| 39 | ASCEND CAPITAL, LLC | 106,400 | 5,758,000 | 0.25% | ||
| 40 | JPMORGAN CHASE & CO | 100,975 | 5,465,000 | 0.24% | ||
| 41 | Employees Retirement System of Texas | 91,000 | 4,925,000 | 0.21% | ||
| 42 | Opaleye Management Inc. | 85,000 | 4,600,000 | 0.20% | ||
| 43 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 75,000 | 4,059,000 | 0.18% | ||
| 44 | TEACHERS ADVISORS, LLC | 69,802 | 3,778,000 | 0.16% | ||
| 45 | MORGAN STANLEY | 68,607 | 3,713,000 | 0.16% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,067 | 3,684,000 | 0.16% | ||
| 47 | PLATINUM INVESTMENT MANAGEMENT LTD | 66,500 | 3,598,000 | 0.16% | ||
| 48 | Swiss National Bank | 62,300 | 3,372,000 | 0.15% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 59,600 | 3,226,000 | 0.14% | ||
| 50 | AMUNDI ASSET MANAGEMENT US, INC. | 58,044 | 3,141,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
