| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 9,941,551 | 296,358,000 | 57.20% | ||
| 2 | CREDIT SUISSE AG/ | 1,809,507 | 53,941,000 | 10.41% | ||
| 3 | FMR LLC | 1,322,874 | 39,435,000 | 7.61% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 948,293 | 28,268,000 | 5.46% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 784,971 | 23,400,000 | 4.52% | ||
| 6 | VANGUARD GROUP INC | 261,205 | 7,786,000 | 1.50% | ||
| 7 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 249,300 | 7,432,000 | 1.43% | ||
| 8 | FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 213,032 | 6,350,000 | 1.23% | ||
| 9 | SAC Capital Advisors LP | 198,753 | 5,925,000 | 1.14% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 181,200 | 5,402,000 | 1.04% | ||
| 11 | BlackRock Fund Advisors | 172,349 | 5,138,000 | 0.99% | ||
| 12 | DOW CHEMICAL CO /DE/ | 149,999 | 4,471,000 | 0.86% | ||
| 13 | PRINCIPAL FINANCIAL GROUP INC | 121,243 | 3,614,000 | 0.70% | ||
| 14 | STATE STREET CORP | 91,492 | 2,728,000 | 0.53% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 85,568 | 2,551,000 | 0.49% | ||
| 16 | NORTHERN TRUST CORP | 76,672 | 2,286,000 | 0.44% | ||
| 17 | HIGHLAND CAPITAL MANAGEMENT LP | 75,153 | 2,240,000 | 0.43% | ||
| 18 | KNOTT DAVID M | 73,500 | 2,191,035 | 0.42% | ||
| 19 | BANK OF AMERICA CORP /DE/ | 61,222 | 1,825,000 | 0.35% | ||
| 20 | Bank of New York Mellon Corp | 50,100 | 1,494,000 | 0.29% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 48,647 | 1,450,000 | 0.28% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 47,300 | 1,410,000 | 0.27% | ||
| 23 | MORGAN STANLEY | 38,000 | 1,133,000 | 0.22% | ||
| 24 | Absolute Return Capital, LLC | 36,993 | 1,103,000 | 0.21% | ||
| 25 | Informed Momentum Co LLC | 35,258 | 1,051,000 | 0.20% | ||
| 26 | D. E. Shaw & Co., Inc. | 32,698 | 975,000 | 0.19% | ||
| 27 | AMERIPRISE FINANCIAL INC | 31,313 | 933,000 | 0.18% | ||
| 28 | Atika Capital Management LLC | 27,500 | 820,000 | 0.16% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 24,253 | 723,000 | 0.14% | ||
| 30 | Spark Investment Management LLC | 18,500 | 551,000 | 0.11% | ||
| 31 | RUSSELL FRANK CO/ | 23,455 | 544,000 | 0.10% | ||
| 32 | BlackRock Investment Management, LLC | 17,702 | 528,000 | 0.10% | ||
| 33 | BLACKROCK ADVISORS LLC | 16,744 | 499,000 | 0.10% | ||
| 34 | A.R.T. Advisors, LLC | 15,736 | 469,000 | 0.09% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,673 | 438,000 | 0.08% | ||
| 36 | GILDER GAGNON HOWE & CO LLC | 11,174 | 333,000 | 0.06% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,000 | 328,000 | 0.06% | ||
| 38 | TEACHERS ADVISORS, LLC | 10,330 | 308,000 | 0.06% | ||
| 39 | Nationwide Fund Advisors | 9,668 | 288,000 | 0.06% | ||
| 40 | PDT Partners, LLC | 9,543 | 284,000 | 0.05% | ||
| 41 | GOLDMAN SACHS GROUP INC | 9,436 | 281,000 | 0.05% | ||
| 42 | METROPOLITAN LIFE INSURANCE CO/NY | 5,501 | 164,000 | 0.03% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,154 | 153,000 | 0.03% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 4,128 | 123,056 | 0.02% | ||
| 45 | CITIGROUP INC | 2,481 | 74,000 | 0.01% | ||
| 46 | BARCLAYS PLC | 2,173 | 63,000 | 0.01% | ||
| 47 | DEUTSCHE BANK AG\ | 1,851 | 54,000 | 0.01% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 1,700 | 51,000 | 0.01% | ||
| 49 | BlackRock Japan Co. Ltd | 1,498 | 45,000 | 0.01% | ||
| 50 | UBS AG | 1,280 | 38,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
