| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 7,400,000 | 136,974,000 | 18.69% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,085,220 | 75,617,000 | 10.32% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,401,419 | 44,449,000 | 6.07% | ||
| 4 | JHL Capital Group LLC | 1,800,000 | 33,318,000 | 4.55% | ||
| 5 | VANGUARD GROUP INC | 1,756,668 | 32,516,000 | 4.44% | ||
| 6 | BlackRock Fund Advisors | 1,730,767 | 32,036,000 | 4.37% | ||
| 7 | STATE STREET CORP | 1,556,434 | 28,807,000 | 3.93% | ||
| 8 | FMR LLC | 1,229,600 | 22,760,000 | 3.11% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,101,000 | 20,380,000 | 2.78% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,062,559 | 19,668,000 | 2.68% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 987,942 | 18,287,000 | 2.50% | ||
| 12 | FRANKLIN RESOURCES INC | 887,900 | 16,435,000 | 2.24% | ||
| 13 | SECTORAL ASSET MANAGEMENT INC | 842,030 | 15,586,000 | 2.13% | ||
| 14 | HealthCor Management, L.P. | 829,041 | 15,346,000 | 2.09% | ||
| 15 | COLUMBUS CIRCLE INVESTORS | 808,098 | 14,958,000 | 2.04% | ||
| 16 | GREAT POINT PARTNERS LLC | 769,047 | 14,235,000 | 1.94% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 707,527 | 13,096,000 | 1.79% | ||
| 18 | VOYA INVESTMENT MANAGEMENT LLC | 663,170 | 12,275,000 | 1.67% | ||
| 19 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 429,800 | 7,956,000 | 1.09% | ||
| 20 | JPMORGAN CHASE & CO | 404,164 | 7,481,000 | 1.02% | ||
| 21 | NORTHERN TRUST CORP | 375,718 | 6,954,000 | 0.95% | ||
| 22 | AXA S.A. | 305,762 | 5,660,000 | 0.77% | ||
| 23 | JENNISON ASSOCIATES LLC | 303,767 | 5,623,000 | 0.77% | ||
| 24 | ROYCE & ASSOCIATES LP | 303,000 | 5,609,000 | 0.77% | ||
| 25 | PERCEPTIVE ADVISORS LLC | 300,000 | 5,553,000 | 0.76% | Call | |
| 26 | EMERALD MUTUAL FUND ADVISERS TRUST | 256,844 | 4,754,000 | 0.65% | ||
| 27 | EMERALD ADVISERS, LLC | 255,830 | 4,735,000 | 0.65% | ||
| 28 | Rock Springs Capital Management LP | 252,000 | 4,665,000 | 0.64% | ||
| 29 | PERCEPTIVE ADVISORS LLC | 250,000 | 4,628,000 | 0.63% | Put | |
| 30 | MORGAN STANLEY | 247,022 | 4,572,000 | 0.62% | ||
| 31 | Asset Management One Co., Ltd. | 257,571 | 4,507,000 | 0.61% | ||
| 32 | BARCLAYS PLC | 224,000 | 4,032,000 | 0.55% | Call | |
| 33 | HIGHLAND CAPITAL MANAGEMENT LP | 216,948 | 4,016,000 | 0.55% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 210,469 | 3,896,000 | 0.53% | ||
| 35 | C WorldWide Group Holding A/S | 200,360 | 3,709,000 | 0.51% | ||
| 36 | BALYASNY ASSET MANAGEMENT L.P. | 178,920 | 3,312,000 | 0.45% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 176,312 | 3,263,000 | 0.45% | ||
| 38 | Bank of New York Mellon Corp | 164,970 | 3,054,000 | 0.42% | ||
| 39 | NORGES BANK | 151,867 | 2,811,000 | 0.38% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 150,719 | 2,790,000 | 0.38% | ||
| 41 | Allianz Asset Management GmbH | 143,340 | 2,653,000 | 0.36% | ||
| 42 | D. E. Shaw & Co., Inc. | 142,583 | 2,639,000 | 0.36% | ||
| 43 | CQS Cayman LP | 141,000 | 2,610,000 | 0.36% | ||
| 44 | KNOTT DAVID M | 135,300 | 2,504,403 | 0.34% | ||
| 45 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 125,620 | 2,325,000 | 0.32% | ||
| 46 | Ghost Tree Capital, LLC | 120,000 | 2,221,000 | 0.30% | ||
| 47 | DEUTSCHE BANK AG\ | 112,912 | 2,088,000 | 0.28% | ||
| 48 | BlackRock Investment Management, LLC | 110,142 | 2,039,000 | 0.28% | ||
| 49 | SPHERA FUNDS MANAGEMENT LTD. | 107,000 | 1,981,000 | 0.27% | ||
| 50 | Weiss Multi-Strategy Advisers LLC | 102,303 | 1,894,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
