| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 7,400,000 | 100,270,000 | 19.50% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,383,213 | 59,394,000 | 11.55% | ||
| 3 | JHL Capital Group LLC | 3,000,000 | 40,650,000 | 7.91% | ||
| 4 | STATE STREET CORP | 2,216,498 | 30,037,000 | 5.84% | ||
| 5 | VANGUARD GROUP INC | 2,083,434 | 28,231,000 | 5.49% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,873,471 | 25,386,000 | 4.94% | ||
| 7 | BlackRock Fund Advisors | 1,773,301 | 24,028,000 | 4.67% | ||
| 8 | FMR LLC | 1,753,800 | 23,764,000 | 4.62% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 1,105,296 | 14,976,000 | 2.91% | ||
| 10 | FRANKLIN RESOURCES INC | 801,100 | 10,855,000 | 2.11% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 729,438 | 9,884,000 | 1.92% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 541,088 | 7,332,000 | 1.43% | ||
| 13 | EMERALD MUTUAL FUND ADVISERS TRUST | 518,859 | 7,031,000 | 1.37% | ||
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 515,790 | 6,989,000 | 1.36% | ||
| 15 | EMERALD ADVISERS, LLC | 507,359 | 6,875,000 | 1.34% | ||
| 16 | ROYCE & ASSOCIATES LP | 467,700 | 6,337,000 | 1.23% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 459,600 | 6,228,000 | 1.21% | Put | |
| 18 | VOYA INVESTMENT MANAGEMENT LLC | 453,720 | 6,148,000 | 1.20% | ||
| 19 | MARSHALL WACE, LLP | 448,773 | 6,081,000 | 1.18% | ||
| 20 | JPMORGAN CHASE & CO | 378,047 | 5,123,000 | 1.00% | ||
| 21 | SCOPIA CAPITAL MANAGEMENT LP | 363,810 | 4,930,000 | 0.96% | ||
| 22 | NORTHERN TRUST CORP | 361,746 | 4,901,000 | 0.95% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 271,911 | 3,685,000 | 0.72% | ||
| 24 | C WorldWide Group Holding A/S | 268,000 | 3,631,000 | 0.71% | ||
| 25 | Asset Management One Co., Ltd. | 259,474 | 3,487,000 | 0.68% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 251,500 | 3,408,000 | 0.66% | Call | |
| 27 | WELLS FARGO & COMPANY/MN | 247,546 | 3,355,000 | 0.65% | ||
| 28 | Portolan Capital Management, LLC | 244,593 | 3,314,000 | 0.64% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 199,763 | 2,706,000 | 0.53% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 194,042 | 2,629,000 | 0.51% | ||
| 31 | GAM Holding AG | 193,000 | 2,615,000 | 0.51% | ||
| 32 | Bank of New York Mellon Corp | 155,843 | 2,112,000 | 0.41% | ||
| 33 | NORGES BANK | 150,537 | 2,040,000 | 0.40% | ||
| 34 | PRINCIPAL FINANCIAL GROUP INC | 146,994 | 1,991,000 | 0.39% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 143,988 | 1,951,000 | 0.38% | ||
| 36 | GOLDMAN SACHS GROUP INC | 137,800 | 1,867,000 | 0.36% | Put | |
| 37 | GOLDMAN SACHS GROUP INC | 137,800 | 1,867,000 | 0.36% | Call | |
| 38 | RICE HALL JAMES & ASSOCIATES, LLC | 131,174 | 1,777,000 | 0.35% | ||
| 39 | GUGGENHEIM CAPITAL LLC | 127,706 | 1,731,000 | 0.34% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 127,300 | 1,725,000 | 0.34% | ||
| 41 | SABBY MANAGEMENT, LLC | 122,905 | 1,665,000 | 0.32% | ||
| 42 | BlackRock Investment Management, LLC | 112,394 | 1,523,000 | 0.30% | ||
| 43 | GROUP ONE TRADING LLC | 110,935 | 1,503,000 | 0.29% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 108,668 | 1,473,000 | 0.29% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 97,000 | 1,314,000 | 0.26% | Put | |
| 46 | Weiss Multi-Strategy Advisers LLC | 83,026 | 1,125,000 | 0.22% | ||
| 47 | TEACHERS ADVISORS, LLC | 69,196 | 938,000 | 0.18% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 69,051 | 936,000 | 0.18% | ||
| 49 | MARCUS CAPITAL, LLC | 65,650 | 890,000 | 0.17% | ||
| 50 | Alyeska Investment Group, L.P. | 62,944 | 853,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
