| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 8,857,551 | 186,806,000 | 37.88% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 2,623,159 | 55,322,000 | 11.22% | ||
| 3 | FMR LLC | 1,266,325 | 26,707,000 | 5.42% | ||
| 4 | FRANKLIN RESOURCES INC | 914,300 | 19,283,000 | 3.91% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 852,392 | 17,977,000 | 3.65% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 762,705 | 16,085,000 | 3.26% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 738,573 | 15,577,000 | 3.16% | ||
| 8 | VANGUARD GROUP INC | 722,551 | 15,239,000 | 3.09% | ||
| 9 | CREDIT SUISSE AG/ | 665,857 | 14,043,000 | 2.85% | ||
| 10 | Point72 Asset Management, L.P. | 662,713 | 13,977,000 | 2.83% | ||
| 11 | Consonance Capital Management LP | 660,462 | 13,929,000 | 2.82% | ||
| 12 | PFM Health Sciences, LP | 589,492 | 12,432,000 | 2.52% | ||
| 13 | BlackRock Fund Advisors | 407,413 | 8,592,000 | 1.74% | ||
| 14 | PointState Capital LP | 325,000 | 6,854,000 | 1.39% | ||
| 15 | STIFEL FINANCIAL CORP | 281,749 | 5,942,000 | 1.20% | ||
| 16 | CITADEL ADVISORS LLC | 275,313 | 5,806,000 | 1.18% | ||
| 17 | Numeric Investors LLC | 274,216 | 5,783,000 | 1.17% | ||
| 18 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 262,300 | 5,532,000 | 1.12% | ||
| 19 | Asset Management One Co., Ltd. | 225,914 | 4,741,000 | 0.96% | ||
| 20 | STATE STREET CORP | 206,338 | 4,351,000 | 0.88% | ||
| 21 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 4,218,000 | 0.86% | ||
| 22 | NORTHERN TRUST CORP | 181,944 | 3,837,000 | 0.78% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 168,445 | 3,553,000 | 0.72% | ||
| 24 | Rock Springs Capital Management LP | 145,000 | 3,058,000 | 0.62% | ||
| 25 | COLUMBUS CIRCLE INVESTORS | 102,972 | 2,172,000 | 0.44% | ||
| 26 | SPHERA FUNDS MANAGEMENT LTD. | 97,100 | 2,048,000 | 0.42% | ||
| 27 | MORGAN STANLEY | 84,383 | 1,779,000 | 0.36% | ||
| 28 | Bank of New York Mellon Corp | 75,981 | 1,602,000 | 0.32% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 73,115 | 1,541,000 | 0.31% | ||
| 30 | DOW CHEMICAL CO /DE/ | 69,899 | 1,474,000 | 0.30% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,035 | 1,350,000 | 0.27% | ||
| 32 | Weiss Multi-Strategy Advisers LLC | 60,000 | 1,265,000 | 0.26% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 52,700 | 1,111,000 | 0.23% | ||
| 34 | BlackRock Investment Management, LLC | 49,482 | 1,044,000 | 0.21% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,012 | 739,000 | 0.15% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,177 | 658,000 | 0.13% | ||
| 37 | GROUP ONE TRADING LLC | 25,109 | 530,000 | 0.11% | ||
| 38 | TEACHERS ADVISORS, LLC | 23,652 | 499,000 | 0.10% | ||
| 39 | SOUTHPORT MANAGEMENT, L.L.C. | 22,500 | 475,000 | 0.10% | ||
| 40 | Nationwide Fund Advisors | 18,139 | 383,000 | 0.08% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 16,420 | 346,000 | 0.07% | ||
| 42 | MARSHALL WACE, LLP | 16,176 | 341,000 | 0.07% | ||
| 43 | UBS AG | 16,077 | 340,000 | 0.07% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 16,100 | 340,000 | 0.07% | ||
| 45 | TFS CAPITAL LLC | 15,915 | 336,000 | 0.07% | ||
| 46 | PRICE T ROWE ASSOCIATES INC /MD/ | 14,169 | 299,000 | 0.06% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 13,518 | 285,000 | 0.06% | ||
| 48 | Partner Investment Management, L.P. | 13,489 | 284,000 | 0.06% | ||
| 49 | RHUMBLINE ADVISERS | 12,720 | 268,000 | 0.05% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,425 | 240,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
