| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 7,400,000 | 244,866,000 | 20.63% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 3,620,366 | 119,798,000 | 10.09% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,764,241 | 58,379,000 | 4.92% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,725,639 | 57,101,000 | 4.81% | ||
| 5 | VANGUARD GROUP INC | 1,718,625 | 56,869,000 | 4.79% | ||
| 6 | BlackRock Fund Advisors | 1,677,730 | 55,516,000 | 4.68% | ||
| 7 | STATE STREET CORP | 1,426,578 | 47,206,000 | 3.98% | ||
| 8 | CITADEL ADVISORS LLC | 1,425,309 | 47,164,000 | 3.97% | ||
| 9 | FMR LLC | 1,182,400 | 39,126,000 | 3.30% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 1,139,142 | 37,694,000 | 3.18% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 842,030 | 27,863,000 | 2.35% | ||
| 12 | JHL Capital Group LLC | 825,000 | 27,299,000 | 2.30% | ||
| 13 | HealthCor Management, L.P. | 822,892 | 27,229,000 | 2.29% | ||
| 14 | COLUMBUS CIRCLE INVESTORS | 714,613 | 23,647,000 | 1.99% | ||
| 15 | FRANKLIN RESOURCES INC | 683,200 | 22,607,000 | 1.90% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 638,149 | 21,116,000 | 1.78% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 596,414 | 19,735,000 | 1.66% | ||
| 18 | SCOPIA CAPITAL MANAGEMENT LP | 374,588 | 12,395,000 | 1.04% | ||
| 19 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 338,500 | 11,201,000 | 0.94% | ||
| 20 | JENNISON ASSOCIATES LLC | 302,200 | 10,000,000 | 0.84% | ||
| 21 | PointState Capital LP | 298,335 | 9,872,000 | 0.83% | ||
| 22 | HIGHLAND CAPITAL MANAGEMENT LP | 298,248 | 9,870,000 | 0.83% | ||
| 23 | ROYCE & ASSOCIATES LP | 250,000 | 8,273,000 | 0.70% | ||
| 24 | Asset Management One Co., Ltd. | 254,470 | 8,191,000 | 0.69% | ||
| 25 | NORTHERN TRUST CORP | 245,608 | 8,127,000 | 0.68% | ||
| 26 | Rock Springs Capital Management LP | 240,100 | 7,945,000 | 0.67% | ||
| 27 | GREAT POINT PARTNERS LLC | 240,000 | 7,942,000 | 0.67% | ||
| 28 | JPMORGAN CHASE & CO | 227,774 | 7,538,000 | 0.64% | ||
| 29 | DEERFIELD MANAGEMENT COMPANY, L.P. | 225,000 | 7,445,000 | 0.63% | ||
| 30 | New Leaf Venture Partners, L.L.C. | 221,204 | 7,320,000 | 0.62% | ||
| 31 | Bank of New York Mellon Corp | 181,411 | 6,003,000 | 0.51% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 173,958 | 5,756,000 | 0.48% | ||
| 33 | D. E. Shaw & Co., Inc. | 170,437 | 5,640,000 | 0.48% | ||
| 34 | Allianz Asset Management GmbH | 143,070 | 4,734,000 | 0.40% | ||
| 35 | C WorldWide Group Holding A/S | 140,000 | 4,633,000 | 0.39% | ||
| 36 | KNOTT DAVID M | 133,100 | 4,404,279 | 0.37% | ||
| 37 | SPHERA FUNDS MANAGEMENT LTD. | 132,000 | 4,368,000 | 0.37% | ||
| 38 | STIFEL FINANCIAL CORP | 130,878 | 4,331,000 | 0.36% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 119,064 | 3,940,000 | 0.33% | ||
| 40 | CABOT WEALTH MANAGEMENT INC | 117,436 | 3,886,000 | 0.33% | ||
| 41 | BlackRock Investment Management, LLC | 110,774 | 3,666,000 | 0.31% | ||
| 42 | MARSHALL WACE, LLP | 110,372 | 3,652,000 | 0.31% | ||
| 43 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 105,369 | 3,487,000 | 0.29% | ||
| 44 | Weiss Multi-Strategy Advisers LLC | 101,000 | 3,342,000 | 0.28% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 90,811 | 3,005,000 | 0.25% | ||
| 46 | Pier Capital, LLC | 81,290 | 2,690,000 | 0.23% | ||
| 47 | PICTET ASSET MANAGEMENT LTD | 77,700 | 2,573,000 | 0.22% | ||
| 48 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 76,700 | 2,538,000 | 0.21% | ||
| 49 | TFS CAPITAL LLC | 75,970 | 2,514,000 | 0.21% | ||
| 50 | DEUTSCHE BANK AG\ | 75,854 | 2,508,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
