| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 9,941,551 | 241,779,000 | 45.77% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 1,556,059 | 37,843,000 | 7.16% | ||
| 3 | FMR LLC | 1,510,774 | 36,742,000 | 6.95% | ||
| 4 | CREDIT SUISSE AG/ | 1,011,709 | 24,604,000 | 4.66% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 894,533 | 21,754,000 | 4.12% | ||
| 6 | Point72 Asset Management, L.P. | 809,000 | 19,675,000 | 3.72% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 712,973 | 17,340,000 | 3.28% | ||
| 8 | VANGUARD GROUP INC | 670,439 | 16,305,000 | 3.09% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 596,605 | 14,509,000 | 2.75% | ||
| 10 | FRANKLIN RESOURCES INC | 587,049 | 14,277,000 | 2.70% | ||
| 11 | BlackRock Fund Advisors | 416,692 | 10,134,000 | 1.92% | ||
| 12 | STIFEL FINANCIAL CORP | 284,650 | 6,923,000 | 1.31% | ||
| 13 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 249,300 | 6,063,000 | 1.15% | ||
| 14 | CITADEL ADVISORS LLC | 222,452 | 5,410,000 | 1.02% | ||
| 15 | STATE STREET CORP | 211,212 | 5,134,000 | 0.97% | ||
| 16 | PointState Capital LP | 200,000 | 4,864,000 | 0.92% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 194,922 | 4,741,000 | 0.90% | ||
| 18 | COLUMBUS CIRCLE INVESTORS | 140,252 | 3,411,000 | 0.65% | ||
| 19 | Rock Springs Capital Management LP | 126,000 | 3,064,000 | 0.58% | ||
| 20 | D. E. Shaw & Co., Inc. | 120,382 | 2,928,000 | 0.55% | ||
| 21 | NORTHERN TRUST CORP | 106,693 | 2,594,000 | 0.49% | ||
| 22 | KNOTT DAVID M | 104,250 | 2,535,360 | 0.48% | ||
| 23 | MORGAN STANLEY | 91,229 | 2,218,000 | 0.42% | ||
| 24 | DOW CHEMICAL CO /DE/ | 89,999 | 2,189,000 | 0.41% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 71,802 | 1,746,000 | 0.33% | ||
| 26 | Bank of New York Mellon Corp | 69,407 | 1,687,000 | 0.32% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,035 | 1,557,000 | 0.29% | ||
| 28 | EverPoint Asset Management, LLC | 60,000 | 1,459,000 | 0.28% | ||
| 29 | PICTET ASSET MANAGEMENT LTD | 52,700 | 1,282,000 | 0.24% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 52,576 | 1,278,000 | 0.24% | ||
| 31 | BlackRock Investment Management, LLC | 48,646 | 1,183,000 | 0.22% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,900 | 751,000 | 0.14% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,561 | 744,000 | 0.14% | ||
| 34 | Weiss Multi-Strategy Advisers LLC | 30,000 | 730,000 | 0.14% | ||
| 35 | Absolute Return Capital, LLC | 28,256 | 687,000 | 0.13% | ||
| 36 | CITIGROUP INC | 24,270 | 590,000 | 0.11% | ||
| 37 | TEACHERS ADVISORS, LLC | 23,652 | 575,000 | 0.11% | ||
| 38 | TFS CAPITAL LLC | 22,654 | 551,000 | 0.10% | ||
| 39 | SOUTHPORT MANAGEMENT, L.L.C. | 22,500 | 547,000 | 0.10% | ||
| 40 | JANE STREET GROUP, LLC | 22,195 | 540,000 | 0.10% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 20,335 | 495,000 | 0.09% | ||
| 42 | Nationwide Fund Advisors | 18,014 | 438,000 | 0.08% | ||
| 43 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 17,724 | 431,000 | 0.08% | ||
| 44 | PRICE T ROWE ASSOCIATES INC /MD/ | 14,169 | 345,000 | 0.07% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 13,518 | 329,000 | 0.06% | ||
| 46 | SECOR Capital Advisors, LP | 12,817 | 312,000 | 0.06% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 12,800 | 311,000 | 0.06% | ||
| 48 | RHUMBLINE ADVISERS | 12,570 | 306,000 | 0.06% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,221 | 273,000 | 0.05% | ||
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 11,059 | 268,955 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
