| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 7,400,000 | 136,900,000 | 18.53% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,513,955 | 83,507,000 | 11.30% | ||
| 3 | VANGUARD GROUP INC | 2,445,249 | 45,237,000 | 6.12% | ||
| 4 | BlackRock Fund Advisors | 1,823,279 | 33,731,000 | 4.57% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,670,383 | 30,902,000 | 4.18% | ||
| 6 | FMR LLC | 1,604,800 | 29,689,000 | 4.02% | ||
| 7 | JHL Capital Group LLC | 1,550,000 | 28,675,000 | 3.88% | ||
| 8 | STATE STREET CORP | 1,391,210 | 25,736,000 | 3.48% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 1,167,214 | 21,593,000 | 2.92% | ||
| 10 | BARCLAYS PLC | 896,100 | 16,578,000 | 2.24% | Call | |
| 11 | FRANKLIN RESOURCES INC | 801,100 | 14,820,000 | 2.01% | ||
| 12 | VOYA INVESTMENT MANAGEMENT LLC | 788,497 | 14,587,000 | 1.97% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 780,000 | 14,430,000 | 1.95% | Put | |
| 14 | BlackRock Institutional Trust Company, N.A. | 769,843 | 14,242,000 | 1.93% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 650,762 | 12,039,000 | 1.63% | ||
| 16 | Avoro Capital Advisors LLC | 613,300 | 11,346,000 | 1.54% | ||
| 17 | ROYCE & ASSOCIATES LP | 583,700 | 10,798,000 | 1.46% | ||
| 18 | MARSHALL WACE, LLP | 462,649 | 8,559,000 | 1.16% | ||
| 19 | WELLS FARGO & COMPANY/MN | 452,790 | 8,377,000 | 1.13% | ||
| 20 | Cormorant Asset Management, LP | 450,000 | 8,325,000 | 1.13% | ||
| 21 | EMERALD MUTUAL FUND ADVISERS TRUST | 447,099 | 8,271,000 | 1.12% | ||
| 22 | EMERALD ADVISERS, LLC | 427,055 | 7,901,000 | 1.07% | ||
| 23 | NORTHERN TRUST CORP | 425,146 | 7,865,000 | 1.06% | ||
| 24 | CITADEL ADVISORS LLC | 418,383 | 7,740,000 | 1.05% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 371,574 | 6,874,000 | 0.93% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 320,200 | 5,924,000 | 0.80% | Call | |
| 27 | JPMORGAN CHASE & CO | 280,235 | 5,185,000 | 0.70% | ||
| 28 | C WorldWide Group Holding A/S | 268,000 | 4,958,000 | 0.67% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 254,226 | 4,703,000 | 0.64% | ||
| 30 | Asset Management One Co., Ltd. | 252,844 | 4,530,000 | 0.61% | ||
| 31 | NORGES BANK | 241,609 | 4,470,000 | 0.60% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 221,569 | 4,099,000 | 0.55% | ||
| 33 | MIZUHO SECURITIES USA LLC | 219,600 | 4,063,000 | 0.55% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 201,921 | 3,736,000 | 0.51% | ||
| 35 | UBS Group AG | 201,062 | 3,720,000 | 0.50% | ||
| 36 | Bank of New York Mellon Corp | 182,237 | 3,370,000 | 0.46% | ||
| 37 | BARCLAYS PLC | 155,500 | 2,877,000 | 0.39% | Put | |
| 38 | PRINCIPAL FINANCIAL GROUP INC | 144,339 | 2,670,000 | 0.36% | ||
| 39 | BlackRock Investment Management, LLC | 140,182 | 2,593,000 | 0.35% | ||
| 40 | J. Goldman & Co LP | 135,100 | 2,499,000 | 0.34% | ||
| 41 | RICE HALL JAMES & ASSOCIATES, LLC | 132,850 | 2,458,000 | 0.33% | ||
| 42 | SPHERA FUNDS MANAGEMENT LTD. | 130,000 | 2,405,000 | 0.33% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 128,808 | 2,383,000 | 0.32% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 123,400 | 2,283,000 | 0.31% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,888 | 2,181,000 | 0.30% | ||
| 46 | GUGGENHEIM CAPITAL LLC | 115,364 | 2,134,000 | 0.29% | ||
| 47 | MIZUHO SECURITIES USA LLC | 219,600 | 2,022,000 | 0.27% | Put | |
| 48 | PERCEPTIVE ADVISORS LLC | 100,000 | 1,850,000 | 0.25% | Put | |
| 49 | Jefferies Group LLC | 100,000 | 1,850,000 | 0.25% | ||
| 50 | FOLGER HILL ASSET MANAGEMENT LP | 100,000 | 1,850,000 | 0.25% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
