| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 8,857,551 | 272,813,000 | 31.52% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 3,241,689 | 99,844,000 | 11.54% | ||
| 3 | New Leaf Venture Partners, L.L.C. | 1,639,665 | 50,502,000 | 5.84% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,239,142 | 38,166,000 | 4.41% | ||
| 5 | VANGUARD GROUP INC | 983,881 | 30,304,000 | 3.50% | ||
| 6 | FRANKLIN RESOURCES INC | 892,700 | 27,495,000 | 3.18% | ||
| 7 | BlackRock Fund Advisors | 870,612 | 26,815,000 | 3.10% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 835,597 | 25,737,000 | 2.97% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 811,330 | 24,989,000 | 2.89% | ||
| 10 | FMR LLC | 765,025 | 23,563,000 | 2.72% | ||
| 11 | PFM Health Sciences, LP | 682,640 | 21,025,000 | 2.43% | ||
| 12 | STIFEL FINANCIAL CORP | 435,052 | 19,526,000 | 2.26% | ||
| 13 | JHL Capital Group LLC | 475,000 | 14,630,000 | 1.69% | ||
| 14 | RTW INVESTMENTS, LP | 450,239 | 13,867,000 | 1.60% | ||
| 15 | CITADEL ADVISORS LLC | 448,484 | 13,813,000 | 1.60% | ||
| 16 | Point72 Asset Management, L.P. | 344,137 | 10,599,000 | 1.22% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 328,400 | 10,115,000 | 1.17% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 312,389 | 9,622,000 | 1.11% | ||
| 19 | Asset Management One Co., Ltd. | 310,178 | 9,581,000 | 1.11% | ||
| 20 | ROYCE & ASSOCIATES LP | 308,000 | 9,486,000 | 1.10% | ||
| 21 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 9,240,000 | 1.07% | ||
| 22 | COLUMBUS CIRCLE INVESTORS | 271,983 | 8,377,000 | 0.97% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 247,370 | 7,619,000 | 0.88% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 223,260 | 6,876,000 | 0.79% | ||
| 25 | STATE STREET CORP | 214,858 | 6,617,000 | 0.76% | ||
| 26 | Rock Springs Capital Management LP | 188,000 | 5,790,000 | 0.67% | ||
| 27 | MARSHALL WACE, LLP | 184,825 | 5,693,000 | 0.66% | ||
| 28 | NORTHERN TRUST CORP | 175,590 | 5,409,000 | 0.62% | ||
| 29 | SPHERA FUNDS MANAGEMENT LTD. | 127,100 | 3,915,000 | 0.45% | ||
| 30 | KNOTT DAVID M | 126,500 | 3,896,200 | 0.45% | ||
| 31 | CABOT WEALTH MANAGEMENT INC | 121,472 | 3,741,000 | 0.43% | ||
| 32 | CREDIT SUISSE AG/ | 117,056 | 3,605,000 | 0.42% | ||
| 33 | TWO SIGMA INVESTMENTS, LP | 99,619 | 3,068,000 | 0.35% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 75,181 | 2,315,000 | 0.27% | ||
| 35 | Bank of New York Mellon Corp | 71,302 | 2,196,000 | 0.25% | ||
| 36 | Weiss Multi-Strategy Advisers LLC | 70,000 | 2,156,000 | 0.25% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 60,155 | 1,853,000 | 0.21% | ||
| 38 | Candriam S.C.A. | 60,000 | 1,848,000 | 0.21% | ||
| 39 | PICTET ASSET MANAGEMENT LTD | 59,600 | 1,836,000 | 0.21% | ||
| 40 | JPMORGAN CHASE & CO | 59,501 | 1,833,000 | 0.21% | ||
| 41 | Alyeska Investment Group, L.P. | 48,697 | 1,500,000 | 0.17% | ||
| 42 | BlackRock Investment Management, LLC | 48,405 | 1,491,000 | 0.17% | ||
| 43 | UBS Group AG | 38,844 | 1,196,000 | 0.14% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,805 | 1,103,000 | 0.13% | ||
| 45 | DOW CHEMICAL CO /DE/ | 35,399 | 1,090,000 | 0.13% | ||
| 46 | D. E. Shaw & Co., Inc. | 34,073 | 1,049,000 | 0.12% | ||
| 47 | MORGAN STANLEY | 32,504 | 1,001,000 | 0.12% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,310 | 964,000 | 0.11% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 28,250 | 870,000 | 0.10% | ||
| 50 | TWO SIGMA ADVISERS, LP | 27,900 | 859,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
