| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 8,857,551 | 319,492,000 | 24.62% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 3,469,796 | 125,156,000 | 9.64% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,789,149 | 64,535,000 | 4.97% | ||
| 4 | CITADEL ADVISORS LLC | 1,505,163 | 54,291,000 | 4.18% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 1,454,142 | 52,451,000 | 4.04% | ||
| 6 | BlackRock Fund Advisors | 1,388,094 | 50,069,000 | 3.86% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 1,387,735 | 50,055,000 | 3.86% | ||
| 8 | VANGUARD GROUP INC | 1,376,669 | 49,656,000 | 3.83% | ||
| 9 | FMR LLC | 1,318,625 | 47,563,000 | 3.67% | ||
| 10 | STATE STREET CORP | 1,195,795 | 43,128,000 | 3.32% | ||
| 11 | COLUMBUS CIRCLE INVESTORS | 949,083 | 34,233,000 | 2.64% | ||
| 12 | HealthCor Management, L.P. | 875,000 | 31,561,000 | 2.43% | ||
| 13 | SECTORAL ASSET MANAGEMENT INC | 837,830 | 30,221,000 | 2.33% | ||
| 14 | New Leaf Venture Partners, L.L.C. | 819,833 | 29,571,000 | 2.28% | ||
| 15 | FRANKLIN RESOURCES INC | 683,200 | 24,643,000 | 1.90% | ||
| 16 | JHL Capital Group LLC | 650,000 | 23,446,000 | 1.81% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 563,100 | 20,311,000 | 1.57% | ||
| 18 | STIFEL FINANCIAL CORP | 552,665 | 19,934,000 | 1.54% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 433,845 | 15,649,000 | 1.21% | ||
| 20 | SCOPIA CAPITAL MANAGEMENT LP | 340,992 | 12,300,000 | 0.95% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 336,200 | 12,127,000 | 0.93% | ||
| 22 | Asset Management One Co., Ltd. | 301,720 | 10,858,000 | 0.84% | ||
| 23 | JENNISON ASSOCIATES LLC | 300,202 | 10,828,000 | 0.83% | ||
| 24 | PointState Capital LP | 300,000 | 10,821,000 | 0.83% | ||
| 25 | ROYCE & ASSOCIATES LP | 250,000 | 9,018,000 | 0.69% | ||
| 26 | HIGHLAND CAPITAL MANAGEMENT LP | 242,855 | 8,760,000 | 0.68% | ||
| 27 | NORTHERN TRUST CORP | 225,244 | 8,125,000 | 0.63% | ||
| 28 | Rock Springs Capital Management LP | 205,000 | 7,394,000 | 0.57% | ||
| 29 | D. E. Shaw & Co., Inc. | 198,646 | 7,165,000 | 0.55% | ||
| 30 | MARSHALL WACE, LLP | 191,362 | 6,902,000 | 0.53% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 156,259 | 5,636,000 | 0.43% | ||
| 32 | JPMORGAN CHASE & CO | 149,671 | 5,398,000 | 0.42% | ||
| 33 | SPHERA FUNDS MANAGEMENT LTD. | 135,000 | 4,869,000 | 0.38% | ||
| 34 | Bank of New York Mellon Corp | 131,169 | 4,732,000 | 0.36% | ||
| 35 | KNOTT DAVID M | 126,500 | 4,562,855 | 0.35% | ||
| 36 | CABOT WEALTH MANAGEMENT INC | 123,267 | 4,446,000 | 0.34% | ||
| 37 | C WorldWide Group Holding A/S | 120,000 | 4,328,000 | 0.33% | ||
| 38 | DRIEHAUS CAPITAL MANAGEMENT LLC | 112,838 | 4,070,000 | 0.31% | ||
| 39 | Weiss Multi-Strategy Advisers LLC | 91,000 | 3,282,000 | 0.25% | ||
| 40 | DEUTSCHE BANK AG\ | 86,610 | 3,123,000 | 0.24% | ||
| 41 | Pier Capital, LLC | 82,204 | 2,965,000 | 0.23% | ||
| 42 | Candriam S.C.A. | 82,000 | 2,958,000 | 0.23% | ||
| 43 | RICE HALL JAMES & ASSOCIATES, LLC | 69,659 | 2,513,000 | 0.19% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 67,121 | 2,421,000 | 0.19% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,569 | 2,402,000 | 0.19% | ||
| 46 | BlackRock Investment Management, LLC | 60,073 | 2,167,000 | 0.17% | ||
| 47 | PICTET ASSET MANAGEMENT LTD | 70,200 | 2,031,000 | 0.16% | ||
| 48 | BELLEVUE ASSET MANAGEMENT AG | 55,000 | 1,984,000 | 0.15% | ||
| 49 | Forward Management, LLC | 55,221 | 1,960,000 | 0.15% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,300 | 1,706,000 | 0.13% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
