| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 7,400,000 | 209,716,000 | 20.64% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 3,770,995 | 106,870,000 | 10.52% | ||
| 3 | JHL Capital Group LLC | 2,250,000 | 63,765,000 | 6.28% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,002,481 | 56,751,000 | 5.59% | ||
| 5 | VANGUARD GROUP INC | 1,959,963 | 55,545,000 | 5.47% | ||
| 6 | BlackRock Fund Advisors | 1,591,108 | 45,092,000 | 4.44% | ||
| 7 | FMR LLC | 1,460,200 | 41,382,000 | 4.07% | ||
| 8 | STATE STREET CORP | 1,075,269 | 30,474,000 | 3.00% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 900,281 | 25,514,000 | 2.51% | ||
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 807,665 | 22,889,000 | 2.25% | ||
| 11 | FRANKLIN RESOURCES INC | 801,100 | 22,703,000 | 2.23% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 720,419 | 20,417,000 | 2.01% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 543,800 | 15,411,000 | 1.52% | Put | |
| 14 | EMERALD ADVISERS, LLC | 491,589 | 13,932,000 | 1.37% | ||
| 15 | EMERALD MUTUAL FUND ADVISERS TRUST | 486,359 | 13,783,000 | 1.36% | ||
| 16 | BALYASNY ASSET MANAGEMENT L.P. | 482,170 | 13,665,000 | 1.34% | ||
| 17 | PointState Capital LP | 450,000 | 12,753,000 | 1.26% | ||
| 18 | VOYA INVESTMENT MANAGEMENT LLC | 447,720 | 12,689,000 | 1.25% | ||
| 19 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 428,900 | 12,155,000 | 1.20% | ||
| 20 | ROYCE & ASSOCIATES LP | 407,700 | 11,554,000 | 1.14% | ||
| 21 | NORTHERN TRUST CORP | 376,149 | 10,660,000 | 1.05% | ||
| 22 | JPMORGAN CHASE & CO | 373,628 | 10,588,000 | 1.04% | ||
| 23 | C WorldWide Group Holding A/S | 293,000 | 8,304,000 | 0.82% | ||
| 24 | COLUMBUS CIRCLE INVESTORS | 282,406 | 8,003,000 | 0.79% | ||
| 25 | Rock Springs Capital Management LP | 252,000 | 7,142,000 | 0.70% | ||
| 26 | Asset Management One Co., Ltd. | 236,488 | 6,893,000 | 0.68% | ||
| 27 | WELLS FARGO & COMPANY/MN | 236,987 | 6,715,000 | 0.66% | ||
| 28 | Opaleye Management Inc. | 220,000 | 6,235,000 | 0.61% | ||
| 29 | NORGES BANK | 201,557 | 5,712,000 | 0.56% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 196,226 | 5,561,000 | 0.55% | ||
| 31 | GAM Holding AG | 193,000 | 5,470,000 | 0.54% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 189,188 | 5,362,000 | 0.53% | ||
| 33 | Bank of New York Mellon Corp | 169,367 | 4,800,000 | 0.47% | ||
| 34 | DEUTSCHE BANK AG\ | 168,232 | 4,767,000 | 0.47% | ||
| 35 | GROUP ONE TRADING LLC | 151,071 | 4,281,000 | 0.42% | ||
| 36 | PRINCIPAL FINANCIAL GROUP INC | 147,986 | 4,193,000 | 0.41% | ||
| 37 | MORGAN STANLEY | 147,171 | 4,171,000 | 0.41% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 140,000 | 3,968,000 | 0.39% | Call | |
| 39 | GOLDMAN SACHS GROUP INC | 139,700 | 3,959,000 | 0.39% | Put | |
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 135,000 | 3,826,000 | 0.38% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 131,812 | 3,736,000 | 0.37% | ||
| 42 | COLUMBUS CIRCLE INVESTORS | 130,000 | 3,684,000 | 0.36% | Call | |
| 43 | BARCLAYS PLC | 129,251 | 3,619,000 | 0.36% | ||
| 44 | RICE HALL JAMES & ASSOCIATES, LLC | 127,234 | 3,606,000 | 0.35% | ||
| 45 | UBS Group AG | 113,985 | 3,230,000 | 0.32% | ||
| 46 | MILLENNIUM MANAGEMENT LLC | 110,726 | 3,138,000 | 0.31% | ||
| 47 | BlackRock Investment Management, LLC | 110,291 | 3,126,000 | 0.31% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 106,548 | 3,020,000 | 0.30% | ||
| 49 | GOLDMAN SACHS GROUP INC | 100,000 | 2,834,000 | 0.28% | Call | |
| 50 | Weiss Multi-Strategy Advisers LLC | 100,000 | 2,834,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
