| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,168,911 | 29,893,000 | 17.34% | ||
| 2 | Broadfin Capital, LLC | 8,501,750 | 19,299,000 | 11.19% | ||
| 3 | Palo Alto Investors LP | 5,176,319 | 11,750,000 | 6.81% | ||
| 4 | OppenheimerFunds, Inc. | 5,000,000 | 11,350,000 | 6.58% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 4,916,925 | 11,162,000 | 6.47% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 3,265,419 | 7,413,000 | 4.30% | ||
| 7 | NEA Management Company, LLC | 3,243,150 | 7,362,000 | 4.27% | ||
| 8 | VANGUARD GROUP INC | 2,994,546 | 6,797,000 | 3.94% | ||
| 9 | BlackRock Fund Advisors | 2,403,188 | 5,455,000 | 3.16% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,397,855 | 5,443,000 | 3.16% | ||
| 11 | SENZAR ASSET MANAGEMENT, LLC | 2,117,987 | 4,808,000 | 2.79% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,969,559 | 4,471,000 | 2.59% | ||
| 13 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,954,300 | 4,436,000 | 2.57% | ||
| 14 | D. E. Shaw & Co., Inc. | 1,557,324 | 3,536,000 | 2.05% | ||
| 15 | DIMENSIONAL FUND ADVISORS LP | 1,452,050 | 3,296,000 | 1.91% | ||
| 16 | STATE STREET CORP | 1,438,116 | 3,267,000 | 1.89% | ||
| 17 | NORTHERN TRUST CORP | 900,566 | 2,044,000 | 1.19% | ||
| 18 | DAFNA Capital Management LLC | 749,066 | 1,700,000 | 0.99% | ||
| 19 | Visium Asset Management, LP | 603,526 | 1,371,000 | 0.80% | ||
| 20 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 631,700 | 1,358,000 | 0.79% | ||
| 21 | BLACKROCK ADVISORS LLC | 545,864 | 1,239,000 | 0.72% | ||
| 22 | Bank of New York Mellon Corp | 538,123 | 1,222,000 | 0.71% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 516,726 | 1,173,000 | 0.68% | ||
| 24 | BAKER BROS. ADVISORS LP | 481,972 | 1,094,000 | 0.63% | ||
| 25 | JACOBS LEVY EQUITY MANAGEMENT, INC | 478,989 | 1,087,000 | 0.63% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 459,326 | 1,042,000 | 0.60% | ||
| 27 | BLUE ARROW CAPITAL MANAGEMENT LLC | 450,000 | 1,022,000 | 0.59% | ||
| 28 | NORGES BANK | 422,815 | 960,000 | 0.56% | ||
| 29 | Healthcare Value Capital, LLC | 400,000 | 908,000 | 0.53% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 364,253 | 827,000 | 0.48% | ||
| 31 | MARSHALL WACE, LLP | 363,519 | 825,000 | 0.48% | ||
| 32 | Telemetry Investments, L.L.C. | 300,000 | 681,000 | 0.39% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 295,349 | 671,000 | 0.39% | ||
| 34 | BlackRock Investment Management, LLC | 290,262 | 659,000 | 0.38% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 287,720 | 653,000 | 0.38% | ||
| 36 | TWO SIGMA INVESTMENTS, LP | 267,647 | 608,000 | 0.35% | ||
| 37 | TWO SIGMA ADVISERS, LP | 257,491 | 585,000 | 0.34% | ||
| 38 | GOLDMAN SACHS GROUP INC | 234,383 | 532,000 | 0.31% | ||
| 39 | BlackRock Group LTD | 227,922 | 517,000 | 0.30% | ||
| 40 | Weiss Multi-Strategy Advisers LLC | 220,000 | 499,000 | 0.29% | ||
| 41 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 217,529 | 495,000 | 0.29% | ||
| 42 | PRICE T ROWE ASSOCIATES INC /MD/ | 217,200 | 493,000 | 0.29% | ||
| 43 | ROYCE & ASSOCIATES LP | 215,392 | 489,000 | 0.28% | ||
| 44 | RUSSELL FRANK CO/ | 215,934 | 488,000 | 0.28% | ||
| 45 | DEUTSCHE BANK AG\ | 207,844 | 470,000 | 0.27% | ||
| 46 | TFS CAPITAL LLC | 205,169 | 466,000 | 0.27% | ||
| 47 | AQR CAPITAL MANAGEMENT LLC | 199,223 | 452,000 | 0.26% | ||
| 48 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 197,600 | 449,000 | 0.26% | ||
| 49 | OXFORD ASSET MANAGEMENT LLP | 185,667 | 426,000 | 0.25% | ||
| 50 | Nationwide Fund Advisors | 162,788 | 370,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
