| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,221,574 | 42,441,000 | 16.76% | ||
| 2 | Broadfin Capital, LLC | 5,876,752 | 18,864,000 | 7.45% | ||
| 3 | Palo Alto Investors LP | 5,176,319 | 16,616,000 | 6.56% | ||
| 4 | OppenheimerFunds, Inc. | 5,000,000 | 16,050,000 | 6.34% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 4,996,564 | 16,040,000 | 6.33% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 3,424,517 | 10,993,000 | 4.34% | ||
| 7 | NEA Management Company, LLC | 3,243,150 | 10,411,000 | 4.11% | ||
| 8 | VANGUARD GROUP INC | 3,166,713 | 10,165,000 | 4.01% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,397,855 | 7,697,000 | 3.04% | ||
| 10 | BlackRock Fund Advisors | 2,302,248 | 7,390,000 | 2.92% | ||
| 11 | D. E. Shaw & Co., Inc. | 2,244,725 | 7,206,000 | 2.84% | ||
| 12 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,954,300 | 6,273,000 | 2.48% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,756,645 | 5,639,000 | 2.23% | ||
| 14 | TFS CAPITAL LLC | 1,747,400 | 5,609,000 | 2.21% | ||
| 15 | DIMENSIONAL FUND ADVISORS LP | 1,624,817 | 5,215,000 | 2.06% | ||
| 16 | STATE STREET CORP | 1,459,379 | 4,688,000 | 1.85% | ||
| 17 | AXA S.A. | 1,324,709 | 4,252,000 | 1.68% | ||
| 18 | SENZAR ASSET MANAGEMENT, LLC | 1,176,487 | 3,777,000 | 1.49% | ||
| 19 | DAFNA Capital Management LLC | 1,109,740 | 3,562,000 | 1.41% | SH | |
| 20 | Numeric Investors LLC | 1,085,967 | 3,486,000 | 1.38% | ||
| 21 | Rhenman & Partners Asset Management AB | 925,000 | 2,969,000 | 1.17% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 881,500 | 2,830,000 | 1.12% | ||
| 23 | NORTHERN TRUST CORP | 846,539 | 2,718,000 | 1.07% | ||
| 24 | MARSHALL WACE, LLP | 697,392 | 2,239,000 | 0.88% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 693,555 | 2,226,000 | 0.88% | ||
| 26 | JACOBS LEVY EQUITY MANAGEMENT, INC | 665,491 | 2,136,000 | 0.84% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 548,450 | 1,760,000 | 0.69% | ||
| 28 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 543,470 | 1,744,000 | 0.69% | ||
| 29 | Bank of New York Mellon Corp | 509,699 | 1,636,000 | 0.65% | ||
| 30 | BLACKROCK ADVISORS LLC | 432,979 | 1,390,000 | 0.55% | ||
| 31 | TWO SIGMA INVESTMENTS, LP | 366,180 | 1,175,000 | 0.46% | ||
| 32 | TWO SIGMA ADVISERS, LP | 346,991 | 1,114,000 | 0.44% | ||
| 33 | BlackRock Investment Management, LLC | 323,610 | 1,039,000 | 0.41% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 313,784 | 1,007,000 | 0.40% | ||
| 35 | Weiss Multi-Strategy Advisers LLC | 300,000 | 963,000 | 0.38% | ||
| 36 | ALLIANCEBERNSTEIN L.P. | 293,720 | 943,000 | 0.37% | ||
| 37 | TURNER INVESTMENTS LLC | 285,020 | 915,000 | 0.36% | ||
| 38 | RUSSELL FRANK CO/ | 266,009 | 854,000 | 0.34% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 254,000 | 815,000 | 0.32% | ||
| 40 | Telemetry Investments, L.L.C. | 250,000 | 802,000 | 0.32% | ||
| 41 | Connor, Clark & Lunn Investment Management Ltd. | 246,600 | 792,000 | 0.31% | ||
| 42 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 245,539 | 788,000 | 0.31% | ||
| 43 | Nationwide Fund Advisors | 236,876 | 760,000 | 0.30% | ||
| 44 | PRICE T ROWE ASSOCIATES INC /MD/ | 222,200 | 713,000 | 0.28% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 201,600 | 648,000 | 0.26% | ||
| 46 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 195,300 | 627,000 | 0.25% | ||
| 47 | MORGAN STANLEY | 178,550 | 573,000 | 0.23% | ||
| 48 | Spark Investment Management LLC | 163,800 | 525,000 | 0.21% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 160,984 | 517,000 | 0.20% | ||
| 50 | DEERE & CO | 157,982 | 507,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
