| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 14,181,146 | 52,045,000 | 16.18% | ||
| 2 | Palo Alto Investors LP | 5,186,088 | 19,033,000 | 5.92% | ||
| 3 | OppenheimerFunds, Inc. | 5,000,000 | 18,350,000 | 5.70% | ||
| 4 | VANGUARD GROUP INC | 4,857,542 | 17,828,000 | 5.54% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 4,816,349 | 17,675,000 | 5.49% | ||
| 6 | BlackRock Fund Advisors | 3,837,675 | 14,084,000 | 4.38% | ||
| 7 | CITADEL ADVISORS LLC | 3,504,359 | 12,861,000 | 4.00% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 3,281,709 | 12,044,000 | 3.74% | ||
| 9 | NEA Management Company, LLC | 3,243,150 | 11,902,000 | 3.70% | ||
| 10 | JPMORGAN CHASE & CO | 2,162,247 | 7,936,000 | 2.47% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 2,102,688 | 7,717,000 | 2.40% | ||
| 12 | D. E. Shaw & Co., Inc. | 1,921,789 | 7,053,000 | 2.19% | ||
| 13 | Rock Springs Capital Management LP | 1,810,000 | 6,643,000 | 2.06% | ||
| 14 | GOLDMAN SACHS GROUP INC | 1,768,094 | 6,489,000 | 2.02% | ||
| 15 | STATE STREET CORP | 1,599,573 | 5,869,000 | 1.82% | ||
| 16 | DIMENSIONAL FUND ADVISORS LP | 1,432,319 | 5,257,000 | 1.63% | ||
| 17 | Rhenman & Partners Asset Management AB | 1,400,000 | 5,138,000 | 1.60% | ||
| 18 | BOXER CAPITAL, LLC | 1,351,137 | 4,959,000 | 1.54% | ||
| 19 | Cormorant Asset Management, LP | 1,155,600 | 4,241,000 | 1.32% | ||
| 20 | NORTHERN TRUST CORP | 1,033,198 | 3,793,000 | 1.18% | ||
| 21 | Sio Capital Management, LLC | 1,020,719 | 3,746,000 | 1.16% | ||
| 22 | PRICE T ROWE ASSOCIATES INC /MD/ | 974,365 | 3,576,000 | 1.11% | ||
| 23 | SENZAR ASSET MANAGEMENT, LLC | 907,203 | 3,329,435 | 1.03% | ||
| 24 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 881,500 | 3,235,000 | 1.01% | ||
| 25 | State of New Jersey Common Pension Fund D | 850,000 | 3,120,000 | 0.97% | ||
| 26 | PAULSON & CO. INC. | 805,000 | 2,954,000 | 0.92% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 802,861 | 2,946,000 | 0.92% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 755,430 | 2,772,000 | 0.86% | ||
| 29 | Candriam S.C.A. | 725,000 | 2,661,000 | 0.83% | ||
| 30 | Ghost Tree Capital, LLC | 700,000 | 2,569,000 | 0.80% | ||
| 31 | Informed Momentum Co LLC | 695,042 | 2,551,000 | 0.79% | ||
| 32 | JACOBS LEVY EQUITY MANAGEMENT, INC | 640,722 | 2,351,000 | 0.73% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 629,800 | 2,311,000 | 0.72% | ||
| 34 | Lombard Odier Asset Management (USA) Corp | 470,000 | 1,725,000 | 0.54% | ||
| 35 | Bank of New York Mellon Corp | 429,114 | 1,575,000 | 0.49% | ||
| 36 | EMERALD ACQUISITION LTD. | 423,390 | 1,553,000 | 0.48% | ||
| 37 | J. Goldman & Co LP | 390,600 | 1,434,000 | 0.45% | Call | |
| 38 | BLACKROCK ADVISORS LLC | 383,690 | 1,408,000 | 0.44% | ||
| 39 | BlackRock Investment Management, LLC | 375,016 | 1,376,000 | 0.43% | ||
| 40 | BALYASNY ASSET MANAGEMENT L.P. | 375,000 | 1,376,000 | 0.43% | ||
| 41 | J. Goldman & Co LP | 361,029 | 1,325,000 | 0.41% | ||
| 42 | NJ State Employees Deferred Compensation Plan | 355,000 | 1,303,000 | 0.40% | ||
| 43 | DAFNA Capital Management LLC | 340,000 | 1,248,000 | 0.39% | ||
| 44 | Nationwide Fund Advisors | 336,177 | 1,234,000 | 0.38% | ||
| 45 | ALGERT GLOBAL LLC | 333,657 | 1,225,000 | 0.38% | ||
| 46 | Connor, Clark & Lunn Investment Management Ltd. | 320,344 | 1,176,000 | 0.37% | ||
| 47 | HAP Trading, LLC | 307,566 | 1,129,000 | 0.35% | ||
| 48 | TWO SIGMA ADVISERS, LP | 273,091 | 1,002,000 | 0.31% | ||
| 49 | DEUTSCHE BANK AG\ | 260,061 | 953,000 | 0.30% | ||
| 50 | MARSHALL WACE, LLP | 208,510 | 765,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
