| 1 |
FMR LLC |
13,206,546 |
47,147,000 |
17.31% |
|
|
| 2 |
Broadfin Capital, LLC |
8,246,329 |
29,439,000 |
10.81% |
|
|
| 3 |
Palo Alto Investors LP |
5,176,319 |
18,479,000 |
6.79% |
|
|
| 4 |
OppenheimerFunds, Inc. |
5,000,000 |
17,850,000 |
6.55% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
4,923,234 |
17,575,000 |
6.45% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
3,269,130 |
11,671,000 |
4.29% |
|
|
| 7 |
NEA Management Company, LLC |
3,243,150 |
11,578,000 |
4.25% |
|
|
| 8 |
VANGUARD GROUP INC |
3,076,919 |
10,984,000 |
4.03% |
|
|
| 9 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
2,397,855 |
8,560,000 |
3.14% |
|
|
| 10 |
BlackRock Fund Advisors |
2,372,617 |
8,470,000 |
3.11% |
|
|
| 11 |
D. E. Shaw & Co., Inc. |
2,075,981 |
7,411,000 |
2.72% |
|
|
| 12 |
SENZAR ASSET MANAGEMENT, LLC |
2,016,287 |
7,198,000 |
2.64% |
|
|
| 13 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
1,954,300 |
6,977,000 |
2.56% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
1,818,792 |
6,493,000 |
2.38% |
|
|
| 15 |
DIMENSIONAL FUND ADVISORS LP |
1,619,764 |
5,782,000 |
2.12% |
|
|
| 16 |
STATE STREET CORP |
1,475,061 |
5,267,000 |
1.93% |
|
|
| 17 |
DAFNA Capital Management LLC |
1,109,740 |
3,962,000 |
1.45% |
|
SH |
| 18 |
Rhenman & Partners Asset Management AB |
1,000,000 |
3,570,000 |
1.31% |
|
|
| 19 |
NORTHERN TRUST CORP |
881,769 |
3,147,000 |
1.16% |
|
|
| 20 |
OXFORD ASSET MANAGEMENT LLP |
653,040 |
2,331,000 |
0.86% |
|
|
| 21 |
MARSHALL WACE, LLP |
572,947 |
2,045,000 |
0.75% |
|
|
| 22 |
BLACKROCK ADVISORS LLC |
547,753 |
1,955,000 |
0.72% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
539,695 |
1,926,000 |
0.71% |
|
|
| 24 |
Bank of New York Mellon Corp |
500,027 |
1,785,000 |
0.66% |
|
|
| 25 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
631,700 |
1,358,000 |
0.50% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
364,253 |
1,300,000 |
0.48% |
|
|
| 27 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
357,607 |
1,277,000 |
0.47% |
|
|
| 28 |
BAKER BROS. ADVISORS LP |
357,187 |
1,275,000 |
0.47% |
|
|
| 29 |
TFS CAPITAL LLC |
329,146 |
1,175,000 |
0.43% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
295,349 |
1,055,000 |
0.39% |
|
|
| 31 |
BlackRock Investment Management, LLC |
288,736 |
1,031,000 |
0.38% |
|
|
| 32 |
ALLIANCEBERNSTEIN L.P. |
287,720 |
1,027,000 |
0.38% |
|
|
| 33 |
TWO SIGMA ADVISERS, LP |
284,791 |
1,017,000 |
0.37% |
|
|
| 34 |
TWO SIGMA INVESTMENTS, LP |
269,073 |
961,000 |
0.35% |
|
|
| 35 |
Nationwide Fund Advisors |
241,908 |
864,000 |
0.32% |
|
|
| 36 |
TURNER INVESTMENTS LLC |
234,880 |
839,000 |
0.31% |
|
|
| 37 |
Weiss Multi-Strategy Advisers LLC |
230,000 |
821,000 |
0.30% |
|
|
| 38 |
PRICE T ROWE ASSOCIATES INC /MD/ |
222,200 |
793,000 |
0.29% |
|
|
| 39 |
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
217,529 |
777,000 |
0.29% |
|
|
| 40 |
Telemetry Investments, L.L.C. |
200,000 |
714,000 |
0.26% |
|
|
| 41 |
DEUTSCHE BANK AG\ |
198,469 |
708,000 |
0.26% |
|
|
| 42 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
197,600 |
705,000 |
0.26% |
|
|
| 43 |
RUSSELL FRANK CO/ |
175,200 |
626,000 |
0.23% |
|
|
| 44 |
Spark Investment Management LLC |
163,800 |
584,000 |
0.21% |
|
|
| 45 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
159,564 |
570,000 |
0.21% |
|
|
| 46 |
FIRST MANHATTAN CO. LLC. |
157,370 |
561,000 |
0.21% |
|
|
| 47 |
NOMURA HOLDINGS INC |
154,939 |
550,000 |
0.20% |
|
|
| 48 |
Healthcare Value Capital, LLC |
150,000 |
536,000 |
0.20% |
|
|
| 49 |
Connor, Clark & Lunn Investment Management Ltd. |
145,400 |
519,000 |
0.19% |
|
|
| 50 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
136,510 |
487,000 |
0.18% |
|
|
