| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,583,384 | 28,253,000 | 16.66% | ||
| 2 | Palo Alto Investors LP | 5,230,919 | 10,880,000 | 6.42% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 5,099,534 | 10,607,000 | 6.26% | ||
| 4 | OppenheimerFunds, Inc. | 5,000,000 | 10,400,000 | 6.13% | ||
| 5 | VANGUARD GROUP INC | 4,503,064 | 9,367,000 | 5.52% | ||
| 6 | BlackRock Fund Advisors | 3,427,862 | 7,130,000 | 4.20% | ||
| 7 | NEA Management Company, LLC | 3,243,150 | 6,746,000 | 3.98% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 3,225,374 | 6,709,000 | 3.96% | ||
| 9 | D. E. Shaw & Co., Inc. | 2,564,859 | 5,335,000 | 3.15% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,397,855 | 4,988,000 | 2.94% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 2,345,756 | 4,879,000 | 2.88% | ||
| 12 | DAFNA Capital Management LLC | 1,876,492 | 3,903,000 | 2.30% | ||
| 13 | Sio Capital Management, LLC | 1,616,896 | 3,363,000 | 1.98% | ||
| 14 | SENZAR ASSET MANAGEMENT, LLC | 1,616,200 | 3,361,696 | 1.98% | ||
| 15 | DIMENSIONAL FUND ADVISORS LP | 1,527,273 | 3,177,000 | 1.87% | ||
| 16 | STATE STREET CORP | 1,479,088 | 3,075,000 | 1.81% | ||
| 17 | Rock Springs Capital Management LP | 1,464,050 | 3,045,000 | 1.80% | ||
| 18 | CITADEL ADVISORS LLC | 1,171,479 | 2,437,000 | 1.44% | ||
| 19 | PAULSON & CO. INC. | 999,700 | 2,079,000 | 1.23% | ||
| 20 | NORTHERN TRUST CORP | 953,240 | 1,983,000 | 1.17% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 881,500 | 1,834,000 | 1.08% | ||
| 22 | TFS CAPITAL LLC | 865,197 | 1,800,000 | 1.06% | ||
| 23 | Rhenman & Partners Asset Management AB | 850,000 | 1,768,000 | 1.04% | ||
| 24 | MARSHALL WACE, LLP | 847,926 | 1,764,000 | 1.04% | ||
| 25 | Numeric Investors LLC | 847,084 | 1,762,000 | 1.04% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 841,512 | 1,750,000 | 1.03% | ||
| 27 | ACUTA CAPITAL PARTNERS, LLC | 776,842 | 1,616,000 | 0.95% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 731,016 | 1,520,000 | 0.90% | ||
| 29 | JACOBS LEVY EQUITY MANAGEMENT, INC | 712,538 | 1,482,000 | 0.87% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 660,800 | 1,374,000 | 0.81% | ||
| 31 | State of New Jersey Common Pension Fund D | 550,000 | 1,144,000 | 0.67% | ||
| 32 | GLOBEFLEX CAPITAL L P | 449,528 | 935,000 | 0.55% | ||
| 33 | Bank of New York Mellon Corp | 449,285 | 934,000 | 0.55% | ||
| 34 | Connor, Clark & Lunn Investment Management Ltd. | 429,544 | 893,000 | 0.53% | ||
| 35 | BLACKROCK ADVISORS LLC | 424,427 | 883,000 | 0.52% | ||
| 36 | J. Goldman & Co LP | 413,789 | 861,000 | 0.51% | ||
| 37 | Spark Investment Management LLC | 318,700 | 662,000 | 0.39% | ||
| 38 | BlackRock Investment Management, LLC | 316,511 | 658,000 | 0.39% | ||
| 39 | NJ State Employees Deferred Compensation Plan | 255,000 | 645,000 | 0.38% | ||
| 40 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 305,445 | 635,000 | 0.37% | ||
| 41 | Weiss Multi-Strategy Advisers LLC | 305,000 | 634,000 | 0.37% | ||
| 42 | TWO SIGMA ADVISERS, LP | 281,191 | 585,000 | 0.35% | ||
| 43 | ALAMBIC INVESTMENT MANAGEMENT, L.P. | 272,895 | 568,000 | 0.33% | ||
| 44 | AMERICAN CENTURY COMPANIES INC | 246,716 | 513,000 | 0.30% | ||
| 45 | RUSSELL FRANK CO/ | 221,308 | 460,000 | 0.27% | ||
| 46 | PRICE T ROWE ASSOCIATES INC /MD/ | 210,360 | 438,000 | 0.26% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 201,600 | 420,000 | 0.25% | ||
| 48 | Telemetry Investments, L.L.C. | 200,000 | 416,000 | 0.25% | ||
| 49 | STRS OHIO | 195,000 | 405,000 | 0.24% | ||
| 50 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 190,000 | 395,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
