| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,278,884 | 40,235,000 | 16.23% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 6,082,344 | 18,429,000 | 7.44% | ||
| 3 | Palo Alto Investors LP | 5,239,119 | 15,875,000 | 6.40% | ||
| 4 | OppenheimerFunds, Inc. | 5,000,000 | 15,150,000 | 6.11% | ||
| 5 | VANGUARD GROUP INC | 3,420,101 | 10,363,000 | 4.18% | ||
| 6 | BlackRock Fund Advisors | 3,375,731 | 10,228,000 | 4.13% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 3,329,793 | 10,089,000 | 4.07% | ||
| 8 | NEA Management Company, LLC | 3,243,150 | 9,827,000 | 3.96% | ||
| 9 | Broadfin Capital, LLC | 3,125,282 | 9,470,000 | 3.82% | ||
| 10 | D. E. Shaw & Co., Inc. | 2,439,996 | 7,393,000 | 2.98% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,397,855 | 7,266,000 | 2.93% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 2,045,596 | 6,198,000 | 2.50% | ||
| 13 | AXA S.A. | 1,934,806 | 5,862,000 | 2.36% | ||
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,745,143 | 5,288,000 | 2.13% | ||
| 15 | DIMENSIONAL FUND ADVISORS LP | 1,620,821 | 4,911,000 | 1.98% | ||
| 16 | SENZAR ASSET MANAGEMENT, LLC | 1,513,500 | 4,585,905 | 1.85% | ||
| 17 | STATE STREET CORP | 1,440,352 | 4,359,000 | 1.76% | ||
| 18 | TFS CAPITAL LLC | 1,251,289 | 3,791,000 | 1.53% | ||
| 19 | DAFNA Capital Management LLC | 1,109,740 | 3,363,000 | 1.36% | SH | |
| 20 | Rock Springs Capital Management LP | 1,100,000 | 3,333,000 | 1.34% | ||
| 21 | NORTHERN TRUST CORP | 943,109 | 2,858,000 | 1.15% | ||
| 22 | Numeric Investors LLC | 887,584 | 2,689,000 | 1.08% | ||
| 23 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 881,500 | 2,671,000 | 1.08% | ||
| 24 | Rhenman & Partners Asset Management AB | 844,313 | 2,558,000 | 1.03% | ||
| 25 | JACOBS LEVY EQUITY MANAGEMENT, INC | 750,738 | 2,275,000 | 0.92% | ||
| 26 | MARSHALL WACE, LLP | 726,128 | 2,200,000 | 0.89% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 691,355 | 2,095,000 | 0.85% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 655,695 | 1,986,000 | 0.80% | ||
| 29 | State of New Jersey Common Pension Fund D | 550,000 | 1,667,000 | 0.67% | ||
| 30 | PAULSON & CO. INC. | 528,700 | 1,602,000 | 0.65% | ||
| 31 | RENAISSANCE TECHNOLOGIES LLC | 499,600 | 1,514,000 | 0.61% | ||
| 32 | Connor, Clark & Lunn Investment Management Ltd. | 460,672 | 1,396,000 | 0.56% | ||
| 33 | ACUTA CAPITAL PARTNERS, LLC | 456,061 | 1,382,000 | 0.56% | ||
| 34 | Bank of New York Mellon Corp | 425,945 | 1,291,000 | 0.52% | ||
| 35 | BLACKROCK ADVISORS LLC | 413,126 | 1,252,000 | 0.51% | ||
| 36 | BlackRock Investment Management, LLC | 320,112 | 970,000 | 0.39% | ||
| 37 | Spark Investment Management LLC | 318,700 | 965,000 | 0.39% | ||
| 38 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 306,842 | 929,000 | 0.37% | ||
| 39 | Weiss Multi-Strategy Advisers LLC | 305,000 | 924,000 | 0.37% | ||
| 40 | TWO SIGMA ADVISERS, LP | 286,291 | 867,000 | 0.35% | ||
| 41 | TURNER INVESTMENTS LLC | 285,020 | 864,000 | 0.35% | ||
| 42 | NJ State Employees Deferred Compensation Plan | 255,000 | 773,000 | 0.31% | ||
| 43 | Telemetry Investments, L.L.C. | 250,000 | 758,000 | 0.31% | ||
| 44 | MORGAN STANLEY | 227,679 | 690,000 | 0.28% | ||
| 45 | RUSSELL FRANK CO/ | 221,308 | 677,000 | 0.27% | ||
| 46 | PRICE T ROWE ASSOCIATES INC /MD/ | 211,650 | 641,000 | 0.26% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 201,600 | 611,000 | 0.25% | ||
| 48 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 195,300 | 592,000 | 0.24% | ||
| 49 | STRS OHIO | 195,000 | 590,000 | 0.24% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 163,362 | 495,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
