| 1 |
FMR LLC |
13,275,627 |
32,791,000 |
16.36% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
5,867,694 |
14,493,000 |
7.23% |
|
|
| 3 |
Palo Alto Investors LP |
5,176,319 |
12,786,000 |
6.38% |
|
|
| 4 |
Broadfin Capital, LLC |
5,125,282 |
12,659,000 |
6.32% |
|
|
| 5 |
OppenheimerFunds, Inc. |
5,000,000 |
12,350,000 |
6.16% |
|
|
| 6 |
VANGUARD GROUP INC |
3,265,830 |
8,067,000 |
4.03% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
3,264,747 |
8,064,000 |
4.02% |
|
|
| 8 |
NEA Management Company, LLC |
3,243,150 |
8,011,000 |
4.00% |
|
|
| 9 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
2,397,855 |
5,923,000 |
2.96% |
|
|
| 10 |
D. E. Shaw & Co., Inc. |
2,293,504 |
5,665,000 |
2.83% |
|
|
| 11 |
BlackRock Fund Advisors |
2,275,817 |
5,621,000 |
2.80% |
|
|
| 12 |
AXA S.A. |
1,975,475 |
4,879,000 |
2.43% |
|
|
| 13 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
1,954,300 |
4,827,000 |
2.41% |
|
|
| 14 |
DIMENSIONAL FUND ADVISORS LP |
1,824,856 |
4,507,000 |
2.25% |
|
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
1,677,440 |
4,143,000 |
2.07% |
|
|
| 16 |
TFS CAPITAL LLC |
1,529,481 |
3,778,000 |
1.89% |
|
|
| 17 |
STATE STREET CORP |
1,437,293 |
3,553,000 |
1.77% |
|
|
| 18 |
ALPS ADVISORS INC |
138,531 |
3,422,000 |
1.71% |
|
|
| 19 |
SENZAR ASSET MANAGEMENT, LLC |
1,375,587 |
3,397,700 |
1.70% |
|
|
| 20 |
DAFNA Capital Management LLC |
1,109,740 |
2,741,000 |
1.37% |
|
SH |
| 21 |
Rhenman & Partners Asset Management AB |
925,000 |
2,285,000 |
1.14% |
|
|
| 22 |
NORTHERN TRUST CORP |
910,123 |
2,248,000 |
1.12% |
|
|
| 23 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
881,500 |
2,177,000 |
1.09% |
|
|
| 24 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
762,491 |
1,883,000 |
0.94% |
|
|
| 25 |
MARSHALL WACE, LLP |
726,128 |
1,794,000 |
0.90% |
|
|
| 26 |
Numeric Investors LLC |
702,691 |
1,736,000 |
0.87% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
630,055 |
1,556,000 |
0.78% |
|
|
| 28 |
GEODE CAPITAL MANAGEMENT, LLC |
577,561 |
1,426,000 |
0.71% |
|
|
| 29 |
State of New Jersey Common Pension Fund D |
550,000 |
1,359,000 |
0.68% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
471,584 |
1,165,000 |
0.58% |
|
|
| 31 |
Bank of New York Mellon Corp |
427,822 |
1,057,000 |
0.53% |
|
|
| 32 |
Connor, Clark & Lunn Investment Management Ltd. |
402,450 |
994,000 |
0.50% |
|
|
| 33 |
RENAISSANCE TECHNOLOGIES LLC |
398,600 |
985,000 |
0.49% |
|
|
| 34 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
348,649 |
861,000 |
0.43% |
|
|
| 35 |
TWO SIGMA ADVISERS, LP |
314,491 |
790,000 |
0.39% |
|
|
| 36 |
BlackRock Investment Management, LLC |
316,909 |
783,000 |
0.39% |
|
|
| 37 |
Spark Investment Management LLC |
312,500 |
768,000 |
0.38% |
|
|
| 38 |
Weiss Multi-Strategy Advisers LLC |
304,000 |
751,000 |
0.37% |
|
|
| 39 |
TURNER INVESTMENTS LLC |
285,020 |
704,000 |
0.35% |
|
|
| 40 |
NJ State Employees Deferred Compensation Plan |
255,000 |
630,000 |
0.31% |
|
|
| 41 |
Telemetry Investments, L.L.C. |
250,000 |
618,000 |
0.31% |
|
|
| 42 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
231,800 |
573,000 |
0.29% |
|
|
| 43 |
PRICE T ROWE ASSOCIATES INC /MD/ |
222,450 |
549,000 |
0.27% |
|
|
| 44 |
RUSSELL FRANK CO/ |
216,390 |
535,000 |
0.27% |
|
|
| 45 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
201,600 |
498,000 |
0.25% |
|
|
| 46 |
ACUTA CAPITAL PARTNERS, LLC |
200,000 |
494,000 |
0.25% |
|
|
| 47 |
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
170,798 |
422,000 |
0.21% |
|
|
| 48 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
160,484 |
396,000 |
0.20% |
|
|
| 49 |
MORGAN STANLEY |
139,398 |
344,000 |
0.17% |
|
|
| 50 |
STRS OHIO |
137,300 |
339,000 |
0.17% |
|
|
