| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,129,343 | 50,942,000 | 16.87% | ||
| 2 | Broadfin Capital, LLC | 5,455,119 | 21,166,000 | 7.01% | ||
| 3 | Palo Alto Investors LP | 5,169,301 | 20,057,000 | 6.64% | ||
| 4 | OppenheimerFunds, Inc. | 5,000,000 | 19,400,000 | 6.42% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 4,474,598 | 17,362,000 | 5.75% | ||
| 6 | VANGUARD GROUP INC | 4,113,181 | 15,959,000 | 5.29% | ||
| 7 | BlackRock Fund Advisors | 3,501,972 | 13,588,000 | 4.50% | ||
| 8 | NEA Management Company, LLC | 3,243,150 | 12,583,000 | 4.17% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,184,370 | 12,355,000 | 4.09% | ||
| 10 | BVF INC/IL | 2,576,707 | 9,998,000 | 3.31% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 2,265,276 | 8,789,000 | 2.91% | ||
| 12 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,900,196 | 7,373,000 | 2.44% | ||
| 13 | D. E. Shaw & Co., Inc. | 1,622,737 | 6,296,000 | 2.09% | ||
| 14 | MORGAN STANLEY | 1,515,010 | 5,878,000 | 1.95% | ||
| 15 | STATE STREET CORP | 1,500,376 | 5,820,000 | 1.93% | ||
| 16 | NORTHERN TRUST CORP | 1,120,380 | 4,347,000 | 1.44% | ||
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,027,443 | 3,986,000 | 1.32% | ||
| 18 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 3,880,000 | 1.28% | ||
| 19 | DIMENSIONAL FUND ADVISORS LP | 999,075 | 3,876,000 | 1.28% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 808,738 | 3,138,000 | 1.04% | ||
| 21 | AQR CAPITAL MANAGEMENT LLC | 717,700 | 2,785,000 | 0.92% | ||
| 22 | NORGES BANK | 687,815 | 2,668,000 | 0.88% | ||
| 23 | Visium Asset Management, LP | 600,060 | 2,329,000 | 0.77% | ||
| 24 | KENNEDY CAPITAL MANAGEMENT LLC | 582,478 | 2,260,000 | 0.75% | ||
| 25 | Polar Capital LLP | 517,823 | 2,009,000 | 0.67% | ||
| 26 | PointState Capital LP | 500,000 | 1,940,000 | 0.64% | ||
| 27 | Bank of New York Mellon Corp | 490,298 | 1,902,000 | 0.63% | ||
| 28 | BAKER BROS. ADVISORS LP | 481,972 | 1,870,000 | 0.62% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 433,672 | 1,682,000 | 0.56% | ||
| 30 | SENZAR ASSET MANAGEMENT, LLC | 421,400 | 1,636,000 | 0.54% | ||
| 31 | DEUTSCHE BANK AG\ | 405,397 | 1,571,000 | 0.52% | ||
| 32 | BLACKROCK ADVISORS LLC | 401,666 | 1,558,000 | 0.52% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 384,570 | 1,492,000 | 0.49% | ||
| 34 | JACOBS LEVY EQUITY MANAGEMENT, INC | 370,593 | 1,438,000 | 0.48% | ||
| 35 | TFS CAPITAL LLC | 365,562 | 1,418,000 | 0.47% | ||
| 36 | ROYCE & ASSOCIATES LP | 309,392 | 1,200,000 | 0.40% | ||
| 37 | TWO SIGMA INVESTMENTS, LP | 303,571 | 1,178,000 | 0.39% | ||
| 38 | BlackRock Investment Management, LLC | 297,076 | 1,153,000 | 0.38% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 296,341 | 1,150,000 | 0.38% | ||
| 40 | TURNER INVESTMENTS LLC | 295,400 | 1,146,000 | 0.38% | ||
| 41 | GOLDMAN SACHS GROUP INC | 250,000 | 970,000 | 0.32% | Put | |
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 240,969 | 935,000 | 0.31% | ||
| 43 | TWO SIGMA ADVISERS, LP | 222,691 | 863,000 | 0.29% | ||
| 44 | GOLDMAN SACHS GROUP INC | 220,895 | 857,000 | 0.28% | ||
| 45 | RENAISSANCE TECHNOLOGIES LLC | 210,526 | 817,000 | 0.27% | ||
| 46 | Neuberger Berman Group LLC | 175,000 | 679,000 | 0.22% | ||
| 47 | BlackRock Group LTD | 164,781 | 639,000 | 0.21% | ||
| 48 | RUSSELL FRANK CO/ | 197,691 | 638,000 | 0.21% | ||
| 49 | LOS ANGELES CAPITAL MANAGEMENT LLC | 161,310 | 626,000 | 0.21% | ||
| 50 | PRICE T ROWE ASSOCIATES INC /MD/ | 157,920 | 613,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
