| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 13,821,657 | 30,822,000 | 16.50% | ||
| 2 | Palo Alto Investors LP | 5,386,534 | 12,012,000 | 6.43% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 5,114,176 | 11,405,000 | 6.11% | ||
| 4 | OppenheimerFunds, Inc. | 5,000,000 | 11,150,000 | 5.97% | ||
| 5 | VANGUARD GROUP INC | 4,622,246 | 10,308,000 | 5.52% | ||
| 6 | BlackRock Fund Advisors | 3,575,734 | 7,974,000 | 4.27% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 3,248,858 | 7,245,000 | 3.88% | ||
| 8 | NEA Management Company, LLC | 3,243,150 | 7,232,000 | 3.87% | ||
| 9 | D. E. Shaw & Co., Inc. | 2,420,146 | 5,397,000 | 2.89% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 2,364,117 | 5,272,000 | 2.82% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,331,366 | 5,199,000 | 2.78% | ||
| 12 | DAFNA Capital Management LLC | 1,847,087 | 4,119,000 | 2.20% | SH | |
| 13 | Rock Springs Capital Management LP | 1,750,000 | 3,903,000 | 2.09% | ||
| 14 | STATE STREET CORP | 1,588,902 | 3,544,000 | 1.90% | ||
| 15 | JPMORGAN CHASE & CO | 1,588,725 | 3,543,000 | 1.90% | ||
| 16 | DIMENSIONAL FUND ADVISORS LP | 1,454,251 | 3,243,000 | 1.74% | ||
| 17 | SENZAR ASSET MANAGEMENT, LLC | 1,443,003 | 3,217,897 | 1.72% | ||
| 18 | Sio Capital Management, LLC | 1,333,696 | 2,974,000 | 1.59% | ||
| 19 | CITADEL ADVISORS LLC | 1,111,111 | 2,478,000 | 1.33% | ||
| 20 | NORTHERN TRUST CORP | 1,021,402 | 2,278,000 | 1.22% | ||
| 21 | PAULSON & CO. INC. | 999,700 | 2,229,000 | 1.19% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 881,500 | 1,966,000 | 1.05% | ||
| 23 | Rhenman & Partners Asset Management AB | 850,000 | 1,896,000 | 1.01% | ||
| 24 | Numeric Investors LLC | 846,584 | 1,888,000 | 1.01% | ||
| 25 | Ghost Tree Capital, LLC | 800,000 | 1,784,000 | 0.96% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 792,600 | 1,767,000 | 0.95% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 747,946 | 1,667,000 | 0.89% | ||
| 28 | ACUTA CAPITAL PARTNERS, LLC | 747,748 | 1,667,000 | 0.89% | ||
| 29 | J. Goldman & Co LP | 729,200 | 1,626,000 | 0.87% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 728,544 | 1,625,000 | 0.87% | ||
| 31 | BOXER CAPITAL, LLC | 700,000 | 1,561,000 | 0.84% | ||
| 32 | JACOBS LEVY EQUITY MANAGEMENT, INC | 659,522 | 1,471,000 | 0.79% | ||
| 33 | State of New Jersey Common Pension Fund D | 550,000 | 1,227,000 | 0.66% | ||
| 34 | Bank of New York Mellon Corp | 436,771 | 974,000 | 0.52% | ||
| 35 | SABBY MANAGEMENT, LLC | 435,957 | 972,000 | 0.52% | ||
| 36 | Connor, Clark & Lunn Investment Management Ltd. | 429,544 | 958,000 | 0.51% | ||
| 37 | BLACKROCK ADVISORS LLC | 425,410 | 949,000 | 0.51% | ||
| 38 | BlackRock Investment Management, LLC | 346,722 | 773,000 | 0.41% | ||
| 39 | GLOBEFLEX CAPITAL L P | 339,528 | 757,000 | 0.41% | ||
| 40 | PUTNAM INVESTMENTS LLC | 291,020 | 649,000 | 0.35% | ||
| 41 | Nationwide Fund Advisors | 289,877 | 646,000 | 0.35% | ||
| 42 | NJ State Employees Deferred Compensation Plan | 255,000 | 569,000 | 0.30% | ||
| 43 | EMERALD ACQUISITION LTD. | 254,964 | 568,000 | 0.30% | ||
| 44 | ALGERT GLOBAL LLC | 247,340 | 552,000 | 0.30% | ||
| 45 | TWO SIGMA ADVISERS, LP | 241,891 | 539,000 | 0.29% | ||
| 46 | TFS CAPITAL LLC | 231,756 | 517,000 | 0.28% | ||
| 47 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 212,663 | 474,000 | 0.25% | ||
| 48 | STRS OHIO | 211,300 | 471,000 | 0.25% | ||
| 49 | PRICE T ROWE ASSOCIATES INC /MD/ | 210,360 | 469,000 | 0.25% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 201,600 | 450,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
