| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 24,516,738 | 795,813,000 | 21.70% | ||
| 2 | FMR LLC | 16,969,451 | 550,828,000 | 15.02% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 7,115,279 | 230,962,000 | 6.30% | ||
| 4 | VANGUARD GROUP INC | 6,368,960 | 206,737,000 | 5.64% | ||
| 5 | OppenheimerFunds, Inc. | 4,991,651 | 162,029,000 | 4.42% | ||
| 6 | Capital World Investors | 3,764,000 | 122,179,000 | 3.33% | ||
| 7 | FRANKLIN RESOURCES INC | 3,366,686 | 109,283,000 | 2.98% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 3,201,615 | 103,923,000 | 2.83% | ||
| 9 | FRED ALGER MANAGEMENT, LLC | 2,385,163 | 77,422,000 | 2.11% | ||
| 10 | BlackRock Fund Advisors | 2,340,012 | 75,957,000 | 2.07% | ||
| 11 | STATE STREET CORP | 2,275,325 | 73,858,000 | 2.01% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 2,194,087 | 71,220,000 | 1.94% | ||
| 13 | LORD, ABBETT & CO. LLC | 2,191,453 | 71,135,000 | 1.94% | ||
| 14 | WADDELL & REED FINANCIAL INC | 1,842,817 | 59,818,000 | 1.63% | ||
| 15 | Palo Alto Investors LP | 1,437,730 | 46,669,000 | 1.27% | ||
| 16 | DEUTSCHE BANK AG\ | 1,353,259 | 43,924,000 | 1.20% | ||
| 17 | Point72 Asset Management, L.P. | 1,199,700 | 38,942,000 | 1.06% | ||
| 18 | Invesco Ltd. | 1,153,267 | 37,436,000 | 1.02% | ||
| 19 | EAGLE ASSET MANAGEMENT INC | 955,027 | 31,000,000 | 0.85% | ||
| 20 | PICTET ASSET MANAGEMENT LTD | 834,727 | 29,574,000 | 0.81% | ||
| 21 | JPMORGAN CHASE & CO | 896,848 | 29,113,000 | 0.79% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 867,500 | 28,159,000 | 0.77% | Put | |
| 23 | FIRST TRUST ADVISORS LP | 856,324 | 27,796,000 | 0.76% | ||
| 24 | Senator Investment Group LP | 800,000 | 25,968,000 | 0.71% | ||
| 25 | NORGES BANK | 773,840 | 25,119,000 | 0.68% | ||
| 26 | VOYA INVESTMENT MANAGEMENT LLC | 716,858 | 23,269,000 | 0.63% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 657,156 | 21,331,000 | 0.58% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 648,089 | 21,036,000 | 0.57% | ||
| 29 | ROYAL BANK OF CANADA | 613,300 | 19,909,000 | 0.54% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 542,100 | 17,597,000 | 0.48% | Call | |
| 31 | CANADA PENSION PLAN INVESTMENT BOARD | 515,000 | 16,717,000 | 0.46% | ||
| 32 | EverPoint Asset Management, LLC | 500,000 | 16,230,000 | 0.44% | ||
| 33 | FEDERATED HERMES, INC. | 491,760 | 15,963,000 | 0.44% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 480,003 | 15,581,000 | 0.42% | ||
| 35 | AMERIPRISE FINANCIAL INC | 429,965 | 13,953,000 | 0.38% | ||
| 36 | NORTHERN TRUST CORP | 408,327 | 13,255,000 | 0.36% | ||
| 37 | Bank of New York Mellon Corp | 404,944 | 13,144,000 | 0.36% | ||
| 38 | WEATHERBIE CAPITAL, LLC | 401,642 | 13,037,000 | 0.36% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 383,440 | 12,446,000 | 0.34% | ||
| 40 | Tekla Capital Management LLC | 363,585 | 11,802,000 | 0.32% | ||
| 41 | HARVEY CAPITAL MANAGEMENT INC | 352,200 | 11,432,000 | 0.31% | ||
| 42 | EVENTIDE ASSET MANAGEMENT, LLC | 334,700 | 10,864,000 | 0.30% | ||
| 43 | GOLDMAN SACHS GROUP INC | 332,361 | 10,788,000 | 0.29% | ||
| 44 | Avoro Capital Advisors LLC | 329,500 | 10,696,000 | 0.29% | ||
| 45 | TimesSquare Capital Management, LLC | 328,800 | 10,673,000 | 0.29% | ||
| 46 | HWG Holdings LP | 289,380 | 9,393,000 | 0.26% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 287,950 | 9,346,000 | 0.25% | ||
| 48 | FRONTIER CAPITAL MANAGEMENT CO LLC | 271,231 | 8,804,000 | 0.24% | ||
| 49 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 238,687 | 7,748,000 | 0.21% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 198,523 | 6,445,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
