| 1 |
RA CAPITAL MANAGEMENT, L.P. |
2,451,237 |
19,732,000 |
11.71% |
|
|
| 2 |
GREAT POINT PARTNERS LLC |
2,440,959 |
19,650,000 |
11.66% |
|
|
| 3 |
FMR LLC |
2,339,328 |
18,832,000 |
11.17% |
|
|
| 4 |
FEDERATED HERMES, INC. |
2,191,106 |
17,638,000 |
10.46% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
1,000,000 |
8,050,000 |
4.78% |
|
|
| 6 |
BlackRock Fund Advisors |
957,272 |
7,706,000 |
4.57% |
|
|
| 7 |
Broadfin Capital, LLC |
882,312 |
7,103,000 |
4.21% |
|
|
| 8 |
GOLDMAN SACHS GROUP INC |
869,399 |
6,999,000 |
4.15% |
|
|
| 9 |
Invesco Ltd. |
854,929 |
6,882,000 |
4.08% |
|
|
| 10 |
VANGUARD GROUP INC |
825,826 |
6,648,000 |
3.94% |
|
|
| 11 |
Lombard Odier Asset Management (USA) Corp |
651,418 |
5,244,000 |
3.11% |
|
|
| 12 |
FRANKLIN RESOURCES INC |
637,525 |
5,132,000 |
3.04% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
541,817 |
4,362,000 |
2.59% |
|
|
| 14 |
KENNEDY CAPITAL MANAGEMENT LLC |
488,580 |
3,933,000 |
2.33% |
|
|
| 15 |
STATE STREET CORP |
415,246 |
3,340,000 |
1.98% |
|
|
| 16 |
SABBY MANAGEMENT, LLC |
289,200 |
2,328,000 |
1.38% |
|
|
| 17 |
NORTHERN TRUST CORP |
279,313 |
2,249,000 |
1.33% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
251,200 |
2,022,000 |
1.20% |
Call |
|
| 19 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
243,595 |
1,961,000 |
1.16% |
|
|
| 20 |
SENZAR ASSET MANAGEMENT, LLC |
214,900 |
1,729,945 |
1.03% |
|
|
| 21 |
DAFNA Capital Management LLC |
197,538 |
1,590,000 |
0.94% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
155,405 |
1,251,000 |
0.74% |
|
|
| 23 |
GAGNON SECURITIES LLC |
153,595 |
1,236,000 |
0.73% |
|
|
| 24 |
CADIAN CAPITAL MANAGEMENT, LP |
147,500 |
1,187,000 |
0.70% |
|
|
| 25 |
Candriam S.C.A. |
105,000 |
845,000 |
0.50% |
|
|
| 26 |
BlackRock Investment Management, LLC |
100,642 |
810,000 |
0.48% |
|
|
| 27 |
Bank of New York Mellon Corp |
82,439 |
664,000 |
0.39% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
78,772 |
634,000 |
0.38% |
|
|
| 29 |
D. E. Shaw & Co., Inc. |
74,427 |
599,000 |
0.36% |
|
|
| 30 |
DIMENSIONAL FUND ADVISORS LP |
69,396 |
559,000 |
0.33% |
|
|
| 31 |
BLAIR WILLIAM & CO/IL |
195,500 |
529,000 |
0.31% |
|
|
| 32 |
CREDIT SUISSE AG/ |
59,382 |
478,000 |
0.28% |
|
|
| 33 |
PURA VIDA INVESTMENTS, LLC |
58,750 |
473,000 |
0.28% |
|
|
| 34 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
57,750 |
465,000 |
0.28% |
|
|
| 35 |
OXFORD ASSET MANAGEMENT LLP |
57,423 |
462,000 |
0.27% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
52,059 |
419,000 |
0.25% |
|
|
| 37 |
Allianz Asset Management GmbH |
40,706 |
328,000 |
0.19% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
40,225 |
324,000 |
0.19% |
|
|
| 39 |
RENAISSANCE TECHNOLOGIES LLC |
37,187 |
299,000 |
0.18% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
36,094 |
291,000 |
0.17% |
|
|
| 41 |
GROUP ONE TRADING LLC |
32,446 |
261,000 |
0.15% |
|
|
| 42 |
Healthcare Value Capital, LLC |
31,850 |
256,000 |
0.15% |
|
|
| 43 |
RHUMBLINE ADVISERS |
30,035 |
242,000 |
0.14% |
|
|
| 44 |
Palo Alto Investors LP |
29,500 |
237,000 |
0.14% |
|
|
| 45 |
NEW YORK STATE COMMON RETIREMENT FUND |
24,164 |
195,000 |
0.12% |
|
|
| 46 |
ProShare Advisors LLC |
21,472 |
173,000 |
0.10% |
|
|
| 47 |
Sunbelt Securities, Inc. |
20,000 |
160,500 |
0.10% |
|
|
| 48 |
METROPOLITAN LIFE INSURANCE CO/NY |
19,892 |
160,000 |
0.09% |
|
|
| 49 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
19,217 |
154,000 |
0.09% |
|
|
| 50 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
17,022 |
137,000 |
0.08% |
|
|
