| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,156,563 | 120,423,000 | 25.51% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,486,274 | 94,851,000 | 20.09% | ||
| 3 | FMR LLC | 783,396 | 29,887,000 | 6.33% | ||
| 4 | BVF INC/IL | 763,300 | 29,120,000 | 6.17% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 552,030 | 21,060,000 | 4.46% | ||
| 6 | GREAT POINT PARTNERS LLC | 400,000 | 15,260,000 | 3.23% | ||
| 7 | SPHERA FUNDS MANAGEMENT LTD. | 400,000 | 15,260,000 | 3.23% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 11,445,000 | 2.42% | ||
| 9 | AWM Investment Company, Inc. | 288,919 | 11,022,000 | 2.33% | ||
| 10 | EverPoint Asset Management, LLC | 285,000 | 10,873,000 | 2.30% | ||
| 11 | VANGUARD GROUP INC | 258,325 | 9,855,000 | 2.09% | ||
| 12 | Informed Momentum Co LLC | 240,507 | 9,175,000 | 1.94% | ||
| 13 | CHARTWELL INVESTMENT PARTNERS, LLC | 227,040 | 8,662,000 | 1.84% | ||
| 14 | VIVO CAPITAL, LLC | 225,000 | 8,584,000 | 1.82% | ||
| 15 | MARSHALL WACE, LLP | 179,480 | 6,847,000 | 1.45% | ||
| 16 | VHCP MANAGEMENT II, LLC | 159,110 | 6,070,000 | 1.29% | ||
| 17 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 154,963 | 5,912,000 | 1.25% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 107,500 | 4,101,000 | 0.87% | ||
| 19 | NEXTHERA CAPITAL LP | 100,000 | 3,815,000 | 0.81% | ||
| 20 | Point72 Asset Management, L.P. | 92,784 | 3,540,000 | 0.75% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 92,600 | 3,533,000 | 0.75% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 89,693 | 3,422,000 | 0.72% | ||
| 23 | PointState Capital LP | 79,700 | 3,041,000 | 0.64% | ||
| 24 | J. Goldman & Co LP | 78,176 | 2,982,000 | 0.63% | ||
| 25 | CITADEL ADVISORS LLC | 77,707 | 2,965,000 | 0.63% | ||
| 26 | Atika Capital Management LLC | 75,000 | 2,862,000 | 0.61% | ||
| 27 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 70,000 | 2,671,000 | 0.57% | ||
| 28 | VHCP Management, LLC | 68,190 | 2,601,000 | 0.55% | ||
| 29 | EMERALD ACQUISITION LTD. | 58,296 | 2,224,000 | 0.47% | ||
| 30 | AMERIPRISE FINANCIAL INC | 57,011 | 2,175,000 | 0.46% | ||
| 31 | TD ASSET MANAGEMENT INC | 56,356 | 2,150,000 | 0.46% | ||
| 32 | Artal Group S.A. | 55,575 | 2,121,000 | 0.45% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 48,723 | 1,858,000 | 0.39% | ||
| 34 | Bank of New York Mellon Corp | 37,686 | 1,438,000 | 0.30% | ||
| 35 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 37,612 | 1,435,000 | 0.30% | ||
| 36 | Weiss Multi-Strategy Advisers LLC | 32,000 | 1,221,000 | 0.26% | ||
| 37 | BAKER BROS. ADVISORS LP | 30,310 | 1,156,000 | 0.24% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 26,135 | 997,000 | 0.21% | ||
| 39 | DEERE & CO | 16,366 | 624,000 | 0.13% | ||
| 40 | MORGAN STANLEY | 12,737 | 486,000 | 0.10% | ||
| 41 | Neuberger Berman Group LLC | 12,000 | 458,000 | 0.10% | ||
| 42 | Virtu KCG Holdings LLC | 11,870 | 453,000 | 0.10% | ||
| 43 | ELLINGTON MANAGEMENT GROUP LLC | 11,500 | 439,000 | 0.09% | ||
| 44 | NORTHERN TRUST CORP | 11,047 | 421,000 | 0.09% | ||
| 45 | MONASHEE INVESTMENT MANAGEMENT LLC | 11,000 | 420,000 | 0.09% | PRN | |
| 46 | KORNITZER CAPITAL MANAGEMENT INC /KS | 10,000 | 381,000 | 0.08% | ||
| 47 | TFS CAPITAL LLC | 9,831 | 375,000 | 0.08% | ||
| 48 | RAYMOND JAMES & ASSOCIATES | 9,000 | 343,000 | 0.07% | ||
| 49 | BlackRock Fund Advisors | 8,565 | 327,000 | 0.07% | ||
| 50 | JANE STREET GROUP, LLC | 5,332 | 203,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
