| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,156,563 | 114,899,000 | 22.81% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,330,434 | 84,828,000 | 16.84% | ||
| 3 | FMR LLC | 1,318,727 | 48,002,000 | 9.53% | ||
| 4 | CITADEL ADVISORS LLC | 704,458 | 25,643,000 | 5.09% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 641,364 | 23,346,000 | 4.64% | ||
| 6 | MARSHALL WACE, LLP | 485,824 | 17,684,000 | 3.51% | ||
| 7 | BVF INC/IL | 484,335 | 17,630,000 | 3.50% | ||
| 8 | GREAT POINT PARTNERS LLC | 437,865 | 15,938,000 | 3.16% | ||
| 9 | VANGUARD GROUP INC | 370,051 | 13,470,000 | 2.67% | ||
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 358,000 | 13,031,000 | 2.59% | ||
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 10,920,000 | 2.17% | ||
| 12 | AWM Investment Company, Inc. | 288,919 | 10,517,000 | 2.09% | ||
| 13 | BlackRock Fund Advisors | 276,194 | 10,053,000 | 2.00% | ||
| 14 | VIVO CAPITAL, LLC | 225,000 | 8,190,000 | 1.63% | ||
| 15 | BALYASNY ASSET MANAGEMENT L.P. | 184,000 | 6,698,000 | 1.33% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 171,700 | 6,250,000 | 1.24% | ||
| 17 | VHCP MANAGEMENT II, LLC | 159,110 | 5,792,000 | 1.15% | ||
| 18 | Informed Momentum Co LLC | 153,586 | 5,591,000 | 1.11% | ||
| 19 | CREDIT SUISSE AG/ | 152,295 | 5,544,000 | 1.10% | ||
| 20 | Point72 Asset Management, L.P. | 139,900 | 5,092,000 | 1.01% | ||
| 21 | J. Goldman & Co LP | 129,500 | 4,714,000 | 0.94% | ||
| 22 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 123,503 | 4,495,000 | 0.89% | ||
| 23 | CITIGROUP INC | 104,107 | 3,789,000 | 0.75% | ||
| 24 | CHARTWELL INVESTMENT PARTNERS, LLC | 83,325 | 3,033,000 | 0.60% | ||
| 25 | PointState Capital LP | 76,968 | 2,802,000 | 0.56% | ||
| 26 | Spark Investment Management LLC | 72,600 | 2,642,000 | 0.52% | ||
| 27 | Atika Capital Management LLC | 68,400 | 2,490,000 | 0.49% | ||
| 28 | VHCP Management, LLC | 68,190 | 2,482,000 | 0.49% | ||
| 29 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 60,461 | 2,201,000 | 0.44% | ||
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 60,000 | 2,184,000 | 0.43% | ||
| 31 | TD ASSET MANAGEMENT INC | 55,956 | 2,037,000 | 0.40% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 53,805 | 1,958,000 | 0.39% | ||
| 33 | Weiss Multi-Strategy Advisers LLC | 50,000 | 1,820,000 | 0.36% | ||
| 34 | RUSSELL INVESTMENTS GROUP, LTD. | 42,998 | 1,584,000 | 0.31% | ||
| 35 | RENAISSANCE TECHNOLOGIES LLC | 41,600 | 1,514,000 | 0.30% | ||
| 36 | BAKER BROS. ADVISORS LP | 30,310 | 1,103,000 | 0.22% | ||
| 37 | Allianz Asset Management GmbH | 29,989 | 1,092,000 | 0.22% | ||
| 38 | AMERIPRISE FINANCIAL INC | 29,814 | 1,085,000 | 0.22% | ||
| 39 | Bank of New York Mellon Corp | 27,930 | 1,017,000 | 0.20% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,600 | 859,000 | 0.17% | Call | |
| 41 | NORTHERN TRUST CORP | 17,911 | 652,000 | 0.13% | ||
| 42 | GOLDMAN SACHS GROUP INC | 16,404 | 597,000 | 0.12% | ||
| 43 | SCHONFELD STRATEGIC ADVISORS LLC | 16,240 | 591,000 | 0.12% | ||
| 44 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 14,587 | 531,000 | 0.11% | ||
| 45 | MORGAN STANLEY | 13,723 | 499,000 | 0.10% | ||
| 46 | ProShare Advisors LLC | 12,716 | 463,000 | 0.09% | ||
| 47 | Swiss National Bank | 12,200 | 444,000 | 0.09% | ||
| 48 | Neuberger Berman Group LLC | 12,000 | 437,000 | 0.09% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,939 | 435,000 | 0.09% | ||
| 50 | STATE STREET CORP | 11,600 | 422,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
