| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,365,592 | 903,404,000 | 14.97% | ||
| 2 | Capital Research Global Investors | 4,381,900 | 737,781,000 | 12.22% | ||
| 3 | BAILLIE GIFFORD & CO | 3,697,412 | 622,533,000 | 10.31% | ||
| 4 | VANGUARD GROUP INC | 2,075,365 | 349,430,000 | 5.79% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,791,241 | 301,591,000 | 5.00% | ||
| 6 | Capital World Investors | 1,358,000 | 228,646,000 | 3.79% | ||
| 7 | ORBIMED ADVISORS LLC | 958,300 | 161,349,000 | 2.67% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 745,061 | 125,446,000 | 2.08% | ||
| 9 | FRANKLIN RESOURCES INC | 702,001 | 118,196,000 | 1.96% | ||
| 10 | OppenheimerFunds, Inc. | 688,350 | 115,897,000 | 1.92% | ||
| 11 | BlackRock Fund Advisors | 686,076 | 115,515,000 | 1.91% | ||
| 12 | LORD, ABBETT & CO. LLC | 604,836 | 101,836,000 | 1.69% | ||
| 13 | DEUTSCHE BANK AG\ | 516,341 | 86,935,000 | 1.44% | ||
| 14 | JENNISON ASSOCIATES LLC | 507,014 | 85,366,000 | 1.41% | ||
| 15 | STATE STREET CORP | 469,538 | 79,058,000 | 1.31% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 402,800 | 67,819,000 | 1.12% | ||
| 17 | GOLDMAN SACHS GROUP INC | 363,206 | 61,153,000 | 1.01% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 351,900 | 59,249,000 | 0.98% | Put | |
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 326,783 | 55,020,000 | 0.91% | ||
| 20 | RS INVESTMENT MANAGEMENT CO LLC | 292,894 | 49,315,000 | 0.82% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 261,038 | 43,951,000 | 0.73% | ||
| 22 | GILDER GAGNON HOWE & CO LLC | 260,142 | 43,800,000 | 0.73% | ||
| 23 | NORTHERN TRUST CORP | 255,170 | 42,963,000 | 0.71% | ||
| 24 | WELLS FARGO & COMPANY/MN | 263,084 | 42,901,000 | 0.71% | ||
| 25 | Tourbillon Capital Partners, L.P. | 250,000 | 42,093,000 | 0.70% | ||
| 26 | Invesco Ltd. | 248,526 | 41,844,000 | 0.69% | ||
| 27 | NORGES BANK | 240,063 | 40,419,000 | 0.67% | ||
| 28 | Passport Capital, LLC | 215,292 | 36,249,000 | 0.60% | ||
| 29 | JANUS HENDERSON INVESTORS US LLC | 210,952 | 35,518,000 | 0.59% | ||
| 30 | Point72 Asset Management, L.P. | 207,100 | 34,869,000 | 0.58% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 206,800 | 34,819,000 | 0.58% | Call | |
| 32 | Artal Group S.A. | 200,000 | 33,674,000 | 0.56% | ||
| 33 | TWO SIGMA INVESTMENTS, LP | 193,504 | 32,580,000 | 0.54% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 180,987 | 30,472,000 | 0.50% | ||
| 35 | Bank of New York Mellon Corp | 162,133 | 27,297,000 | 0.45% | ||
| 36 | FRED ALGER MANAGEMENT, LLC | 158,442 | 26,677,000 | 0.44% | ||
| 37 | CREDIT SUISSE AG/ | 156,661 | 26,376,000 | 0.44% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 154,981 | 26,094,000 | 0.43% | ||
| 39 | COLUMBUS CIRCLE INVESTORS | 153,037 | 25,767,000 | 0.43% | ||
| 40 | BAKER BROS. ADVISORS LP | 151,105 | 25,442,000 | 0.42% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 149,249 | 25,129,000 | 0.42% | ||
| 42 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 148,615 | 25,022,000 | 0.41% | ||
| 43 | AMERICAN CENTURY COMPANIES INC | 127,561 | 21,477,000 | 0.36% | ||
| 44 | PFM Health Sciences, LP | 127,170 | 21,412,000 | 0.35% | ||
| 45 | Mitsubishi UFJ Trust & Banking Corp | 124,080 | 20,891,000 | 0.35% | ||
| 46 | JPMORGAN CHASE & CO | 123,346 | 20,767,000 | 0.34% | ||
| 47 | GLG LLC | 118,717 | 19,988,000 | 0.33% | ||
| 48 | QVT Financial LP | 117,844 | 19,841,000 | 0.33% | ||
| 49 | RA CAPITAL MANAGEMENT, L.P. | 109,383 | 18,417,000 | 0.31% | ||
| 50 | AMERIPRISE FINANCIAL INC | 106,813 | 17,983,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
