| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,501,537 | 353,309,000 | 13.58% | ||
| 2 | BAILLIE GIFFORD & CO | 4,883,321 | 313,607,000 | 12.05% | ||
| 3 | Capital Research Global Investors | 4,452,741 | 285,955,000 | 10.99% | ||
| 4 | VANGUARD GROUP INC | 2,371,577 | 152,303,000 | 5.85% | ||
| 5 | Capital World Investors | 2,075,000 | 133,257,000 | 5.12% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,005,303 | 128,781,000 | 4.95% | ||
| 7 | OppenheimerFunds, Inc. | 1,316,324 | 84,534,000 | 3.25% | ||
| 8 | STATE STREET CORP | 954,682 | 61,310,000 | 2.36% | ||
| 9 | ORBIMED ADVISORS LLC | 941,700 | 60,476,000 | 2.32% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 879,313 | 56,469,000 | 2.17% | ||
| 11 | JENNISON ASSOCIATES LLC | 864,314 | 55,506,000 | 2.13% | ||
| 12 | BlackRock Fund Advisors | 771,142 | 49,523,000 | 1.90% | ||
| 13 | FRANKLIN RESOURCES INC | 765,661 | 49,171,000 | 1.89% | ||
| 14 | PFM Health Sciences, LP | 667,840 | 42,889,000 | 1.65% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 539,500 | 34,647,000 | 1.33% | ||
| 16 | RS INVESTMENT MANAGEMENT CO LLC | 515,846 | 33,128,000 | 1.27% | ||
| 17 | AMERIPRISE FINANCIAL INC | 503,407 | 32,331,000 | 1.24% | ||
| 18 | WELLS FARGO & COMPANY/MN | 474,832 | 30,492,000 | 1.17% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 434,600 | 27,910,000 | 1.07% | Put | |
| 20 | DEUTSCHE BANK AG\ | 429,645 | 27,590,000 | 1.06% | ||
| 21 | Artal Group S.A. | 360,000 | 23,119,000 | 0.89% | ||
| 22 | COLUMBUS CIRCLE INVESTORS | 315,957 | 20,291,000 | 0.78% | ||
| 23 | GILDER GAGNON HOWE & CO LLC | 295,327 | 18,966,000 | 0.73% | ||
| 24 | GOLDMAN SACHS GROUP INC | 266,034 | 17,085,000 | 0.66% | ||
| 25 | CAPITAL FUND MANAGEMENT S.A. | 258,634 | 16,609,000 | 0.64% | ||
| 26 | ArrowMark Colorado Holdings LLC | 248,328 | 15,948,000 | 0.61% | ||
| 27 | NORGES BANK | 241,230 | 15,492,000 | 0.60% | ||
| 28 | EMERALD ADVISERS, LLC | 230,252 | 14,787,000 | 0.57% | ||
| 29 | Invesco Ltd. | 227,322 | 14,598,000 | 0.56% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226,000 | 14,514,000 | 0.56% | Call | |
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 220,243 | 14,143,000 | 0.54% | ||
| 32 | EMERALD MUTUAL FUND ADVISERS TRUST | 192,375 | 12,354,000 | 0.47% | ||
| 33 | State of Tennessee, Department of Treasury | 191,963 | 12,328,000 | 0.47% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 175,271 | 11,256,000 | 0.43% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 171,022 | 10,983,000 | 0.42% | ||
| 36 | MARSHALL WACE, LLP | 168,427 | 10,816,000 | 0.42% | ||
| 37 | Mitsubishi UFJ Trust & Banking Corp | 163,850 | 10,522,000 | 0.40% | ||
| 38 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 156,472 | 10,049,000 | 0.39% | ||
| 39 | Bank of New York Mellon Corp | 149,263 | 9,587,000 | 0.37% | ||
| 40 | FRONTIER CAPITAL MANAGEMENT CO LLC | 146,707 | 9,422,000 | 0.36% | ||
| 41 | UBS Group AG | 145,883 | 9,369,000 | 0.36% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 145,057 | 9,316,000 | 0.36% | ||
| 43 | JANUS HENDERSON INVESTORS US LLC | 143,469 | 9,214,000 | 0.35% | ||
| 44 | BAKER BROS. ADVISORS LP | 141,105 | 9,062,000 | 0.35% | ||
| 45 | BALYASNY ASSET MANAGEMENT L.P. | 134,261 | 8,622,000 | 0.33% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 134,169 | 8,616,000 | 0.33% | ||
| 47 | NORTHERN TRUST CORP | 134,065 | 8,610,000 | 0.33% | ||
| 48 | AXA S.A. | 124,798 | 8,015,000 | 0.31% | ||
| 49 | Ghost Tree Capital, LLC | 120,000 | 7,706,000 | 0.30% | ||
| 50 | CASDIN CAPITAL, LLC | 100,000 | 6,422,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
