| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,046,196 | 72,262,000 | 10.00% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,575,221 | 65,517,000 | 9.07% | ||
| 3 | BAKER BROS. ADVISORS LP | 4,472,153 | 64,041,000 | 8.86% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,139,787 | 59,282,000 | 8.21% | ||
| 5 | Palo Alto Investors LP | 3,786,908 | 54,229,000 | 7.51% | ||
| 6 | PAULSON & CO. INC. | 3,625,000 | 51,910,000 | 7.19% | ||
| 7 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,461,305 | 35,246,000 | 4.88% | ||
| 8 | STATE STREET CORP | 1,877,584 | 26,888,000 | 3.72% | ||
| 9 | BlackRock Fund Advisors | 1,553,289 | 22,243,000 | 3.08% | ||
| 10 | MORGAN STANLEY | 1,457,718 | 20,874,000 | 2.89% | ||
| 11 | VANGUARD GROUP INC | 1,180,527 | 16,905,000 | 2.34% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,137,570 | 16,290,000 | 2.25% | ||
| 13 | Invesco Ltd. | 1,022,178 | 14,638,000 | 2.03% | ||
| 14 | Signpost Capital Advisors, LP | 828,793 | 11,868,000 | 1.64% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 812,770 | 11,639,000 | 1.61% | ||
| 16 | ARMISTICE CAPITAL, LLC | 728,000 | 10,425,000 | 1.44% | ||
| 17 | WALL STREET ASSOCIATES | 655,800 | 9,391,000 | 1.30% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 600,000 | 8,592,000 | 1.19% | Call | |
| 19 | BARCLAYS PLC | 531,700 | 7,444,000 | 1.03% | Put | |
| 20 | Jefferies Group LLC | 514,300 | 7,365,000 | 1.02% | Call | |
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 503,695 | 7,213,000 | 1.00% | ||
| 22 | RTW INVESTMENTS, LP | 500,000 | 7,160,000 | 0.99% | ||
| 23 | NORTHERN TRUST CORP | 447,798 | 6,412,000 | 0.89% | ||
| 24 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000 | 5,370,000 | 0.74% | ||
| 25 | D. E. Shaw & Co., Inc. | 369,271 | 5,288,000 | 0.73% | ||
| 26 | SPHERA FUNDS MANAGEMENT LTD. | 368,390 | 5,275,000 | 0.73% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 368,200 | 5,273,000 | 0.73% | Call | |
| 28 | OXFORD ASSET MANAGEMENT LLP | 340,287 | 4,951,000 | 0.69% | ||
| 29 | NEXT CENTURY GROWTH INVESTORS LLC | 338,102 | 4,841,000 | 0.67% | ||
| 30 | Alyeska Investment Group, L.P. | 280,000 | 4,010,000 | 0.56% | ||
| 31 | J. Goldman & Co LP | 277,173 | 3,969,000 | 0.55% | ||
| 32 | DEUTSCHE BANK AG\ | 256,398 | 3,670,000 | 0.51% | ||
| 33 | BARCLAYS PLC | 236,152 | 3,306,000 | 0.46% | ||
| 34 | First Light Asset Management, LLC | 229,818 | 3,291,000 | 0.46% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 221,105 | 3,166,000 | 0.44% | ||
| 36 | Bank of New York Mellon Corp | 213,895 | 3,063,000 | 0.42% | ||
| 37 | CREDIT AGRICOLE S A | 212,184 | 2,960,000 | 0.41% | ||
| 38 | J. Goldman & Co LP | 197,500 | 2,828,000 | 0.39% | Call | |
| 39 | PRINCIPAL FINANCIAL GROUP INC | 188,500 | 2,699,000 | 0.37% | ||
| 40 | GOLDMAN SACHS GROUP INC | 178,643 | 2,558,000 | 0.35% | ||
| 41 | PURA VIDA INVESTMENTS, LLC | 175,000 | 2,506,000 | 0.35% | Call | |
| 42 | Forward Management, LLC | 172,300 | 2,196,000 | 0.30% | ||
| 43 | BARCLAYS PLC | 152,600 | 2,136,000 | 0.30% | Call | |
| 44 | TD ASSET MANAGEMENT INC | 139,600 | 1,999,000 | 0.28% | ||
| 45 | AMERIPRISE FINANCIAL INC | 134,194 | 1,922,000 | 0.27% | ||
| 46 | MACQUARIE GROUP LTD | 130,000 | 1,862,000 | 0.26% | ||
| 47 | BlackRock Investment Management, LLC | 113,210 | 1,621,000 | 0.22% | ||
| 48 | QS Investors, LLC | 110,486 | 1,583,000 | 0.22% | ||
| 49 | PERCEPTIVE ADVISORS LLC | 100,000 | 1,432,000 | 0.20% | Put | |
| 50 | WELLINGTON MANAGEMENT GROUP LLP | 99,010 | 1,418,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
