| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,996,691 | 55,829,000 | 13.88% | ||
| 2 | Palo Alto Investors LP | 4,030,908 | 37,528,000 | 9.33% | ||
| 3 | PAULSON & CO. INC. | 3,946,500 | 36,742,000 | 9.14% | ||
| 4 | GREAT POINT PARTNERS LLC | 2,100,101 | 19,552,000 | 4.86% | ||
| 5 | STONEPINE CAPITAL MANAGEMENT, LLC | 1,918,929 | 17,865,000 | 4.44% | ||
| 6 | STATE STREET CORP | 1,688,766 | 15,721,000 | 3.91% | ||
| 7 | ARMISTICE CAPITAL, LLC | 1,630,000 | 15,175,000 | 3.77% | ||
| 8 | BlackRock Fund Advisors | 1,622,846 | 15,109,000 | 3.76% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,535,770 | 14,298,000 | 3.56% | ||
| 10 | VANGUARD GROUP INC | 1,484,928 | 13,825,000 | 3.44% | ||
| 11 | MORGAN STANLEY | 1,436,808 | 13,376,000 | 3.33% | ||
| 12 | Avoro Capital Advisors LLC | 1,260,809 | 11,738,000 | 2.92% | ||
| 13 | BANK OF MONTREAL /CAN/ | 1,208,918 | 11,255,000 | 2.80% | ||
| 14 | Consonance Capital Management LP | 1,093,696 | 10,182,000 | 2.53% | ||
| 15 | MACQUARIE GROUP LTD | 1,089,532 | 10,144,000 | 2.52% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 1,078,042 | 10,037,000 | 2.50% | ||
| 17 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 934,568 | 8,701,000 | 2.16% | ||
| 18 | J. Goldman & Co LP | 902,839 | 8,405,000 | 2.09% | ||
| 19 | NORTHERN TRUST CORP | 506,051 | 4,711,000 | 1.17% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 462,051 | 4,302,000 | 1.07% | ||
| 21 | QS Investors, LLC | 446,646 | 4,158,000 | 1.03% | ||
| 22 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 422,300 | 4,084,000 | 1.02% | ||
| 23 | DEUTSCHE BANK AG\ | 431,230 | 4,014,000 | 1.00% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 347,732 | 3,237,000 | 0.81% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 337,390 | 3,141,000 | 0.78% | ||
| 26 | Invesco Ltd. | 316,287 | 2,944,000 | 0.73% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 268,633 | 2,501,000 | 0.62% | ||
| 28 | ASCEND CAPITAL, LLC | 249,596 | 2,324,000 | 0.58% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226,200 | 2,106,000 | 0.52% | Call | |
| 30 | PRINCIPAL FINANCIAL GROUP INC | 208,500 | 1,941,000 | 0.48% | ||
| 31 | Bank of New York Mellon Corp | 187,586 | 1,746,000 | 0.43% | ||
| 32 | PDT Partners, LLC | 174,560 | 1,625,000 | 0.40% | ||
| 33 | BlackRock Investment Management, LLC | 151,152 | 1,407,000 | 0.35% | ||
| 34 | FMR LLC | 150,078 | 1,397,000 | 0.35% | ||
| 35 | UBS Group AG | 138,346 | 1,288,000 | 0.32% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 134,546 | 1,253,000 | 0.31% | ||
| 37 | CONVECTOR CAPITAL MANAGEMENT, LP | 128,500 | 1,196,000 | 0.30% | ||
| 38 | CITADEL ADVISORS LLC | 109,815 | 1,022,000 | 0.25% | ||
| 39 | CREDIT AGRICOLE S A | 100,784 | 938,000 | 0.23% | ||
| 40 | GOLDMAN SACHS GROUP INC | 97,300 | 906,000 | 0.23% | Call | |
| 41 | GOLDMAN SACHS GROUP INC | 93,900 | 874,000 | 0.22% | Put | |
| 42 | THRIVENT FINANCIAL FOR LUTHERANS | 93,060 | 866,000 | 0.22% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,500 | 852,000 | 0.21% | Put | |
| 44 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 88,844 | 827,000 | 0.21% | ||
| 45 | Connor, Clark & Lunn Investment Management Ltd. | 84,000 | 782,000 | 0.19% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 77,415 | 721,000 | 0.18% | ||
| 47 | TFS CAPITAL LLC | 77,342 | 720,000 | 0.18% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 73,700 | 686,000 | 0.17% | ||
| 49 | PERCEPTIVE ADVISORS LLC | 71,849 | 669,000 | 0.17% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 55,528 | 626,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
