| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,515,096 | 73,370,000 | 11.61% | ||
| 2 | BAKER BROS. ADVISORS LP | 4,445,696 | 72,243,000 | 11.43% | ||
| 3 | Palo Alto Investors LP | 3,215,424 | 52,251,000 | 8.27% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,751,881 | 28,468,000 | 4.51% | ||
| 5 | STATE STREET CORP | 1,554,430 | 25,262,000 | 4.00% | ||
| 6 | Invesco Ltd. | 1,484,145 | 24,118,000 | 3.82% | ||
| 7 | PAULSON & CO. INC. | 1,392,500 | 22,628,000 | 3.58% | ||
| 8 | BlackRock Fund Advisors | 1,336,039 | 21,711,000 | 3.44% | ||
| 9 | Consonance Capital Management LP | 1,226,772 | 19,935,000 | 3.15% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,153,942 | 18,740,000 | 2.97% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,079,870 | 17,548,000 | 2.78% | ||
| 12 | GOLDMAN SACHS GROUP INC | 1,036,200 | 16,838,000 | 2.66% | Call | |
| 13 | VANGUARD GROUP INC | 1,002,342 | 16,288,000 | 2.58% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 993,500 | 16,144,000 | 2.55% | Call | |
| 15 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 760,000 | 12,350,000 | 1.95% | Call | |
| 16 | WALL STREET ASSOCIATES | 705,100 | 11,458,000 | 1.81% | ||
| 17 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 606,489 | 9,855,000 | 1.56% | ||
| 18 | Bank of New York Mellon Corp | 512,461 | 8,326,000 | 1.32% | ||
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 501,709 | 8,153,000 | 1.29% | ||
| 20 | ORBIMED ADVISORS LLC | 462,400 | 7,514,000 | 1.19% | ||
| 21 | NORTHERN TRUST CORP | 448,087 | 7,281,000 | 1.15% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 433,278 | 7,041,000 | 1.11% | ||
| 23 | MORGAN STANLEY | 368,973 | 5,996,000 | 0.95% | ||
| 24 | DEUTSCHE BANK AG\ | 363,846 | 5,911,000 | 0.94% | ||
| 25 | ALTRINSIC GLOBAL ADVISORS LLC | 350,000 | 5,688,000 | 0.90% | ||
| 26 | GOLDMAN SACHS GROUP INC | 329,280 | 5,351,000 | 0.85% | ||
| 27 | MACQUARIE GROUP LTD | 280,000 | 4,550,000 | 0.72% | ||
| 28 | Independence Capital Asset Partners, LLC | 269,917 | 4,386,000 | 0.69% | ||
| 29 | Jefferies Group LLC | 268,400 | 4,362,000 | 0.69% | Call | |
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 264,000 | 4,290,000 | 0.68% | Put | |
| 31 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 240,370 | 3,907,000 | 0.62% | ||
| 32 | BALYASNY ASSET MANAGEMENT L.P. | 225,480 | 3,664,000 | 0.58% | ||
| 33 | D. E. Shaw & Co., Inc. | 220,882 | 3,589,000 | 0.57% | ||
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 214,792 | 3,490,000 | 0.55% | ||
| 35 | THB ASSET MANAGEMENT | 207,900 | 3,378,000 | 0.53% | ||
| 36 | Hudson Bay Capital Management LP | 206,909 | 3,362,000 | 0.53% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 200,000 | 3,250,000 | 0.51% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 189,929 | 3,086,000 | 0.49% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 189,200 | 3,075,000 | 0.49% | ||
| 40 | OXFORD ASSET MANAGEMENT LLP | 180,017 | 2,925,000 | 0.46% | ||
| 41 | MARSHALL WACE, LLP | 170,104 | 2,764,000 | 0.44% | ||
| 42 | GOLDMAN SACHS GROUP INC | 167,200 | 2,717,000 | 0.43% | Put | |
| 43 | Connor, Clark & Lunn Investment Management Ltd. | 144,707 | 2,595,000 | 0.41% | ||
| 44 | Lombard Odier Asset Management (USA) Corp | 150,000 | 2,438,000 | 0.39% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 146,148 | 2,375,000 | 0.38% | ||
| 46 | GROUP ONE TRADING LLC | 138,549 | 2,251,000 | 0.36% | ||
| 47 | WELLINGTON MANAGEMENT GROUP LLP | 126,400 | 2,054,000 | 0.33% | ||
| 48 | HIGHLAND CAPITAL MANAGEMENT LP | 123,090 | 2,000,000 | 0.32% | ||
| 49 | GAGNON SECURITIES LLC | 111,118 | 1,806,000 | 0.29% | ||
| 50 | SMITH ASSET MANAGEMENT GROUP LP | 109,874 | 1,785,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
