| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,996,691 | 67,103,000 | 15.81% | ||
| 2 | Palo Alto Investors LP | 4,225,608 | 47,285,000 | 11.14% | ||
| 3 | PAULSON & CO. INC. | 3,864,717 | 43,246,000 | 10.19% | ||
| 4 | GREAT POINT PARTNERS LLC | 2,705,758 | 30,277,000 | 7.14% | ||
| 5 | MORGAN STANLEY | 1,895,315 | 21,209,000 | 5.00% | ||
| 6 | VANGUARD GROUP INC | 1,608,935 | 18,003,000 | 4.24% | ||
| 7 | MACQUARIE GROUP LTD | 1,532,533 | 17,149,000 | 4.04% | ||
| 8 | BlackRock Fund Advisors | 1,517,007 | 16,975,000 | 4.00% | ||
| 9 | STATE STREET CORP | 1,285,054 | 14,385,000 | 3.39% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,108,854 | 12,408,000 | 2.92% | ||
| 11 | STONEPINE CAPITAL MANAGEMENT, LLC | 811,563 | 9,081,000 | 2.14% | ||
| 12 | ARMISTICE CAPITAL, LLC | 800,000 | 8,952,000 | 2.11% | ||
| 13 | Avoro Capital Advisors LLC | 709,579 | 7,940,000 | 1.87% | ||
| 14 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 644,568 | 7,213,000 | 1.70% | ||
| 15 | NORTHERN TRUST CORP | 482,597 | 5,401,000 | 1.27% | ||
| 16 | QS Investors, LLC | 470,965 | 5,270,000 | 1.24% | ||
| 17 | J. Goldman & Co LP | 463,900 | 5,191,000 | 1.22% | ||
| 18 | TEACHERS ADVISORS, LLC | 454,871 | 5,090,000 | 1.20% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 436,911 | 4,889,000 | 1.15% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 367,657 | 4,114,000 | 0.97% | ||
| 21 | PRUDENTIAL FINANCIAL INC | 354,108 | 3,962,000 | 0.93% | ||
| 22 | GOLDMAN SACHS GROUP INC | 347,886 | 3,893,000 | 0.92% | ||
| 23 | DEUTSCHE BANK AG\ | 326,765 | 3,654,000 | 0.86% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 313,088 | 3,504,000 | 0.83% | ||
| 25 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 300,000 | 3,357,000 | 0.79% | Call | |
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 298,773 | 3,343,000 | 0.79% | ||
| 27 | D. E. Shaw & Co., Inc. | 219,757 | 2,459,000 | 0.58% | ||
| 28 | PRINCIPAL FINANCIAL GROUP INC | 203,600 | 2,278,000 | 0.54% | ||
| 29 | AJO, LP | 195,915 | 2,192,000 | 0.52% | ||
| 30 | Bank of New York Mellon Corp | 194,796 | 2,179,000 | 0.51% | ||
| 31 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 187,100 | 2,094,000 | 0.49% | ||
| 32 | RENAISSANCE TECHNOLOGIES LLC | 151,050 | 1,690,000 | 0.40% | ||
| 33 | ACADIAN ASSET MANAGEMENT LLC | 149,689 | 1,675,000 | 0.39% | ||
| 34 | BlackRock Investment Management, LLC | 147,700 | 1,653,000 | 0.39% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 126,078 | 1,411,000 | 0.33% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 117,513 | 1,315,000 | 0.31% | ||
| 37 | PDT Partners, LLC | 115,760 | 1,295,000 | 0.31% | ||
| 38 | CREDIT SUISSE AG/ | 104,487 | 1,169,000 | 0.28% | ||
| 39 | GOLDMAN SACHS GROUP INC | 102,900 | 1,151,000 | 0.27% | Call | |
| 40 | TWO SIGMA INVESTMENTS, LP | 98,615 | 1,104,000 | 0.26% | ||
| 41 | BLACKROCK ADVISORS LLC | 96,756 | 1,083,000 | 0.26% | ||
| 42 | GOLDMAN SACHS GROUP INC | 94,000 | 1,052,000 | 0.25% | Put | |
| 43 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 89,624 | 1,003,000 | 0.24% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 76,840 | 860,000 | 0.20% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 71,000 | 795,000 | 0.19% | ||
| 46 | CONVECTOR CAPITAL MANAGEMENT, LP | 70,000 | 783,000 | 0.18% | ||
| 47 | JPMORGAN CHASE & CO | 69,912 | 782,000 | 0.18% | ||
| 48 | Jefferies Group LLC | 67,864 | 759,000 | 0.18% | ||
| 49 | COLUMBUS CIRCLE INVESTORS | 66,478 | 744,000 | 0.18% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,300 | 720,000 | 0.17% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
