| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Palo Alto Investors LP | 4,110,708 | 68,402,000 | 9.51% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,435,576 | 57,168,000 | 7.95% | ||
| 3 | GREAT POINT PARTNERS LLC | 2,706,134 | 45,030,000 | 6.26% | ||
| 4 | PAULSON & CO. INC. | 2,175,000 | 36,192,000 | 5.03% | ||
| 5 | MORGAN STANLEY | 1,841,634 | 30,645,000 | 4.26% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 1,681,681 | 27,983,000 | 3.89% | ||
| 7 | VANGUARD GROUP INC | 1,665,414 | 27,713,000 | 3.85% | ||
| 8 | BlackRock Fund Advisors | 1,591,102 | 26,476,000 | 3.68% | ||
| 9 | STATE STREET CORP | 1,377,510 | 22,921,000 | 3.19% | ||
| 10 | MACQUARIE GROUP LTD | 1,285,749 | 21,395,000 | 2.98% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,105,311 | 18,392,000 | 2.56% | ||
| 12 | OXFORD ASSET MANAGEMENT LLP | 1,005,330 | 16,729,000 | 2.33% | ||
| 13 | AJO, LP | 875,320 | 14,565,000 | 2.03% | ||
| 14 | GOLDMAN SACHS GROUP INC | 840,162 | 13,980,000 | 1.94% | ||
| 15 | Avoro Capital Advisors LLC | 827,693 | 13,773,000 | 1.92% | ||
| 16 | ORBIMED ADVISORS LLC | 750,000 | 12,480,000 | 1.74% | Call | |
| 17 | PRUDENTIAL FINANCIAL INC | 598,518 | 9,959,000 | 1.39% | ||
| 18 | ARMISTICE CAPITAL, LLC | 550,000 | 9,152,000 | 1.27% | ||
| 19 | Point72 Asset Management, L.P. | 542,700 | 9,031,000 | 1.26% | ||
| 20 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 529,076 | 8,803,000 | 1.22% | ||
| 21 | GOLDMAN SACHS GROUP INC | 503,100 | 8,372,000 | 1.16% | Put | |
| 22 | TEACHERS ADVISORS, LLC | 491,341 | 8,176,000 | 1.14% | ||
| 23 | NORTHERN TRUST CORP | 482,019 | 8,021,000 | 1.12% | ||
| 24 | QS Investors, LLC | 470,965 | 7,837,000 | 1.09% | ||
| 25 | CASTLEARK MANAGEMENT LLC | 465,545 | 7,747,000 | 1.08% | ||
| 26 | ACADIAN ASSET MANAGEMENT LLC | 458,284 | 7,626,000 | 1.06% | ||
| 27 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 452,200 | 7,525,000 | 1.05% | Call | |
| 28 | EverPoint Asset Management, LLC | 450,000 | 7,488,000 | 1.04% | ||
| 29 | RENAISSANCE TECHNOLOGIES LLC | 432,050 | 7,189,000 | 1.00% | ||
| 30 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 402,456 | 6,697,000 | 0.93% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 395,965 | 6,589,000 | 0.92% | ||
| 32 | Lombard Odier Asset Management (USA) Corp | 395,000 | 6,573,000 | 0.91% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 378,964 | 6,306,000 | 0.88% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 372,309 | 6,195,000 | 0.86% | ||
| 35 | D. E. Shaw & Co., Inc. | 346,055 | 5,758,000 | 0.80% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 308,500 | 5,133,000 | 0.71% | Put | |
| 37 | ALLIANCEBERNSTEIN L.P. | 270,678 | 4,504,000 | 0.63% | ||
| 38 | PNC FINANCIAL SERVICES GROUP, INC. | 262,498 | 4,368,000 | 0.61% | ||
| 39 | ACUTA CAPITAL PARTNERS, LLC | 245,995 | 4,093,000 | 0.57% | ||
| 40 | DEUTSCHE BANK AG\ | 227,479 | 3,784,000 | 0.53% | ||
| 41 | Candriam S.C.A. | 217,000 | 3,611,000 | 0.50% | ||
| 42 | KENNEDY CAPITAL MANAGEMENT LLC | 206,327 | 3,433,000 | 0.48% | ||
| 43 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 205,600 | 3,420,000 | 0.48% | ||
| 44 | PRINCIPAL FINANCIAL GROUP INC | 204,849 | 3,409,000 | 0.47% | ||
| 45 | CREDIT SUISSE AG/ | 199,045 | 3,311,000 | 0.46% | ||
| 46 | Bank of New York Mellon Corp | 176,414 | 2,936,000 | 0.41% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 175,779 | 2,925,000 | 0.41% | ||
| 48 | JPMORGAN CHASE & CO | 154,313 | 2,568,000 | 0.36% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,800 | 2,543,000 | 0.35% | Call | |
| 50 | Allianz Asset Management GmbH | 152,464 | 2,537,000 | 0.35% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
