| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GOLDMAN SACHS GROUP INC | 4,205,392 | 39,110,000 | 8.48% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,134,157 | 38,448,000 | 8.33% | ||
| 3 | PAULSON & CO. INC. | 3,950,000 | 36,735,000 | 7.96% | ||
| 4 | Palo Alto Investors LP | 3,803,408 | 35,372,000 | 7.67% | ||
| 5 | FMR LLC | 2,955,429 | 27,485,000 | 5.96% | ||
| 6 | STATE STREET CORP | 2,685,595 | 24,974,000 | 5.41% | ||
| 7 | ARMISTICE CAPITAL, LLC | 2,284,000 | 21,241,000 | 4.60% | ||
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,932,189 | 17,969,000 | 3.90% | ||
| 9 | BAKER BROS. ADVISORS LP | 1,750,230 | 16,277,000 | 3.53% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,599,162 | 14,872,000 | 3.22% | ||
| 11 | BlackRock Fund Advisors | 1,485,191 | 13,812,000 | 2.99% | ||
| 12 | MORGAN STANLEY | 1,421,114 | 13,217,000 | 2.87% | ||
| 13 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,400,000 | 13,020,000 | 2.82% | Call | |
| 14 | GREAT POINT PARTNERS LLC | 1,388,599 | 12,914,000 | 2.80% | ||
| 15 | VANGUARD GROUP INC | 1,248,686 | 11,612,000 | 2.52% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 1,111,149 | 10,334,000 | 2.24% | ||
| 17 | Invesco Ltd. | 1,022,178 | 9,506,000 | 2.06% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 931,800 | 8,666,000 | 1.88% | Call | |
| 19 | Jefferies Group LLC | 830,402 | 7,723,000 | 1.67% | ||
| 20 | MACQUARIE GROUP LTD | 709,474 | 6,598,000 | 1.43% | ||
| 21 | J. Goldman & Co LP | 584,285 | 5,434,000 | 1.18% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 543,390 | 5,054,000 | 1.10% | ||
| 23 | NORTHERN TRUST CORP | 462,602 | 4,303,000 | 0.93% | ||
| 24 | KENNEDY CAPITAL MANAGEMENT LLC | 396,070 | 3,683,000 | 0.80% | ||
| 25 | DEUTSCHE BANK AG\ | 382,419 | 3,554,000 | 0.77% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 365,628 | 3,400,000 | 0.74% | ||
| 27 | D. E. Shaw & Co., Inc. | 352,781 | 3,281,000 | 0.71% | ||
| 28 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000 | 3,255,000 | 0.71% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 224,072 | 2,083,000 | 0.45% | ||
| 30 | Bank of New York Mellon Corp | 220,731 | 2,053,000 | 0.45% | ||
| 31 | Alyeska Investment Group, L.P. | 202,216 | 1,881,000 | 0.41% | ||
| 32 | PRINCIPAL FINANCIAL GROUP INC | 201,635 | 1,875,000 | 0.41% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 195,100 | 1,814,000 | 0.39% | ||
| 34 | GOLDMAN SACHS GROUP INC | 180,700 | 1,681,000 | 0.36% | Call | |
| 35 | ASCEND CAPITAL, LLC | 168,300 | 1,566,000 | 0.34% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 162,892 | 1,515,000 | 0.33% | ||
| 37 | BLUE ARROW CAPITAL MANAGEMENT LLC | 160,000 | 1,488,000 | 0.32% | ||
| 38 | UBS Group AG | 145,800 | 1,356,000 | 0.29% | Call | |
| 39 | BARCLAYS PLC | 138,600 | 1,247,000 | 0.27% | Call | |
| 40 | TFS CAPITAL LLC | 132,314 | 1,231,000 | 0.27% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 128,249 | 1,193,000 | 0.26% | ||
| 42 | SABBY MANAGEMENT, LLC | 113,165 | 1,052,000 | 0.23% | ||
| 43 | QS Investors, LLC | 110,486 | 1,027,000 | 0.22% | ||
| 44 | BlackRock Investment Management, LLC | 103,719 | 965,000 | 0.21% | ||
| 45 | CREDIT AGRICOLE S A | 100,784 | 937,000 | 0.20% | ||
| 46 | PERCEPTIVE ADVISORS LLC | 100,000 | 930,000 | 0.20% | Put | |
| 47 | PERCEPTIVE ADVISORS LLC | 100,000 | 930,000 | 0.20% | Call | |
| 48 | SG Americas Securities, LLC | 99,604 | 926,000 | 0.20% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 73,700 | 879,000 | 0.19% | ||
| 50 | WELLINGTON MANAGEMENT GROUP LLP | 89,640 | 834,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
