| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Palo Alto Investors LP | 4,203,270 | 67,042,000 | 9.93% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,424,676 | 54,624,000 | 8.09% | ||
| 3 | BlackRock Fund Advisors | 2,270,297 | 36,211,000 | 5.36% | ||
| 4 | GREAT POINT PARTNERS LLC | 2,010,000 | 32,060,000 | 4.75% | ||
| 5 | VANGUARD GROUP INC | 1,972,678 | 31,464,000 | 4.66% | ||
| 6 | MORGAN STANLEY | 1,786,540 | 28,496,000 | 4.22% | ||
| 7 | STATE STREET CORP | 1,751,605 | 27,935,000 | 4.14% | ||
| 8 | MACQUARIE GROUP LTD | 1,372,640 | 21,894,000 | 3.24% | ||
| 9 | ACADIAN ASSET MANAGEMENT LLC | 1,370,655 | 21,863,000 | 3.24% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,224,332 | 19,528,000 | 2.89% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 1,021,171 | 16,288,000 | 2.41% | ||
| 12 | FMR LLC | 996,271 | 15,891,000 | 2.35% | ||
| 13 | AJO, LP | 804,206 | 12,827,000 | 1.90% | ||
| 14 | OXFORD ASSET MANAGEMENT LLP | 757,507 | 12,082,000 | 1.79% | ||
| 15 | ORBIMED ADVISORS LLC | 750,000 | 11,963,000 | 1.77% | Call | |
| 16 | PRUDENTIAL FINANCIAL INC | 609,618 | 9,723,000 | 1.44% | ||
| 17 | CASTLEARK MANAGEMENT LLC | 583,960 | 9,314,000 | 1.38% | ||
| 18 | ARMISTICE CAPITAL, LLC | 580,000 | 9,251,000 | 1.37% | ||
| 19 | RENAISSANCE TECHNOLOGIES LLC | 568,350 | 9,065,000 | 1.34% | ||
| 20 | TEACHERS ADVISORS, LLC | 530,681 | 8,464,000 | 1.25% | ||
| 21 | EverPoint Asset Management, LLC | 525,000 | 8,374,000 | 1.24% | ||
| 22 | GOLDMAN SACHS GROUP INC | 501,800 | 8,004,000 | 1.19% | Put | |
| 23 | Numeric Investors LLC | 496,600 | 7,921,000 | 1.17% | ||
| 24 | Invesco Ltd. | 488,025 | 7,784,000 | 1.15% | ||
| 25 | NORTHERN TRUST CORP | 484,552 | 7,729,000 | 1.14% | ||
| 26 | GOLDMAN SACHS GROUP INC | 472,909 | 7,542,000 | 1.12% | ||
| 27 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 450,847 | 7,191,000 | 1.07% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 434,303 | 6,928,000 | 1.03% | ||
| 29 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 418,732 | 6,679,000 | 0.99% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 389,278 | 6,209,000 | 0.92% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 388,583 | 6,197,000 | 0.92% | ||
| 32 | RUSSELL INVESTMENTS GROUP, LTD. | 384,810 | 6,196,000 | 0.92% | ||
| 33 | Avoro Capital Advisors LLC | 381,466 | 6,084,000 | 0.90% | ||
| 34 | QS Investors, LLC | 351,241 | 5,602,000 | 0.83% | ||
| 35 | D. E. Shaw & Co., Inc. | 333,619 | 5,322,000 | 0.79% | ||
| 36 | PNC FINANCIAL SERVICES GROUP, INC. | 282,292 | 4,502,000 | 0.67% | ||
| 37 | DEUTSCHE BANK AG\ | 263,800 | 4,206,000 | 0.62% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 260,700 | 4,158,000 | 0.62% | Put | |
| 39 | ALLIANCEBERNSTEIN L.P. | 249,028 | 3,972,000 | 0.59% | ||
| 40 | Candriam S.C.A. | 237,000 | 3,780,000 | 0.56% | ||
| 41 | PRINCIPAL FINANCIAL GROUP INC | 215,275 | 3,434,000 | 0.51% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 196,066 | 3,127,000 | 0.46% | ||
| 43 | CREDIT SUISSE AG/ | 186,556 | 2,975,000 | 0.44% | ||
| 44 | Bank of New York Mellon Corp | 185,893 | 2,965,000 | 0.44% | ||
| 45 | JPMORGAN CHASE & CO | 180,312 | 2,876,000 | 0.43% | ||
| 46 | WELLINGTON MANAGEMENT GROUP LLP | 165,959 | 2,647,000 | 0.39% | ||
| 47 | ACUTA CAPITAL PARTNERS, LLC | 162,600 | 2,593,000 | 0.38% | ||
| 48 | TWO SIGMA ADVISERS, LP | 160,800 | 2,565,000 | 0.38% | ||
| 49 | CITADEL ADVISORS LLC | 156,183 | 2,491,000 | 0.37% | ||
| 50 | Point72 Asset Management, L.P. | 151,100 | 2,410,000 | 0.36% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
