| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,784,157 | 60,711,000 | 11.05% | ||
| 2 | PAULSON & CO. INC. | 3,946,500 | 50,081,000 | 9.11% | ||
| 3 | Palo Alto Investors LP | 3,897,408 | 49,458,000 | 9.00% | ||
| 4 | GOLDMAN SACHS GROUP INC | 2,836,486 | 35,995,000 | 6.55% | ||
| 5 | STATE STREET CORP | 2,569,617 | 32,610,000 | 5.93% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,141,835 | 27,180,000 | 4.94% | ||
| 7 | BlackRock Fund Advisors | 1,641,711 | 20,833,000 | 3.79% | ||
| 8 | MORGAN STANLEY | 1,457,511 | 18,495,000 | 3.36% | ||
| 9 | Avoro Capital Advisors LLC | 1,438,693 | 18,257,000 | 3.32% | ||
| 10 | GREAT POINT PARTNERS LLC | 1,413,599 | 17,939,000 | 3.26% | ||
| 11 | VANGUARD GROUP INC | 1,381,756 | 17,535,000 | 3.19% | ||
| 12 | ARMISTICE CAPITAL, LLC | 1,142,000 | 14,492,000 | 2.64% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 1,126,256 | 14,292,000 | 2.60% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 1,083,759 | 13,753,000 | 2.50% | ||
| 15 | Invesco Ltd. | 1,022,605 | 12,977,000 | 2.36% | ||
| 16 | EverPoint Asset Management, LLC | 900,000 | 11,421,000 | 2.08% | ||
| 17 | BANK OF MONTREAL /CAN/ | 863,022 | 10,951,000 | 1.99% | ||
| 18 | MACQUARIE GROUP LTD | 814,571 | 10,337,000 | 1.88% | ||
| 19 | J. Goldman & Co LP | 746,184 | 9,469,000 | 1.72% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 513,390 | 6,515,000 | 1.19% | ||
| 21 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 475,000 | 6,028,000 | 1.10% | ||
| 22 | NORTHERN TRUST CORP | 414,156 | 5,256,000 | 0.96% | ||
| 23 | BAKER BROS. ADVISORS LP | 409,881 | 5,201,000 | 0.95% | ||
| 24 | Ghost Tree Capital, LLC | 350,000 | 4,442,000 | 0.81% | ||
| 25 | PURA VIDA INVESTMENTS, LLC | 307,500 | 3,764,000 | 0.68% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 295,545 | 3,750,000 | 0.68% | ||
| 27 | DEUTSCHE BANK AG\ | 242,256 | 3,073,000 | 0.56% | ||
| 28 | D. E. Shaw & Co., Inc. | 232,062 | 2,945,000 | 0.54% | ||
| 29 | Bank of New York Mellon Corp | 231,736 | 2,940,000 | 0.53% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 227,600 | 2,888,000 | 0.53% | Call | |
| 31 | KENNEDY CAPITAL MANAGEMENT LLC | 210,462 | 2,671,000 | 0.49% | ||
| 32 | PRINCIPAL FINANCIAL GROUP INC | 206,300 | 2,618,000 | 0.48% | ||
| 33 | CREDIT SUISSE AG/ | 199,072 | 2,527,000 | 0.46% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 187,600 | 2,381,000 | 0.43% | Put | |
| 35 | J. Goldman & Co LP | 180,000 | 2,284,000 | 0.42% | Call | |
| 36 | Alyeska Investment Group, L.P. | 163,676 | 2,077,000 | 0.38% | ||
| 37 | BlackRock Investment Management, LLC | 150,622 | 1,911,000 | 0.35% | ||
| 38 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 135,022 | 1,713,000 | 0.31% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 129,115 | 1,638,000 | 0.30% | ||
| 40 | QS Investors, LLC | 110,486 | 1,402,000 | 0.26% | ||
| 41 | PDT Partners, LLC | 109,090 | 1,384,000 | 0.25% | ||
| 42 | GOLDMAN SACHS GROUP INC | 108,400 | 1,376,000 | 0.25% | Call | |
| 43 | CITADEL ADVISORS LLC | 106,293 | 1,349,000 | 0.25% | ||
| 44 | CREDIT AGRICOLE S A | 100,784 | 1,279,000 | 0.23% | ||
| 45 | SG Americas Securities, LLC | 100,708 | 1,278,000 | 0.23% | ||
| 46 | GOLDMAN SACHS GROUP INC | 99,500 | 1,263,000 | 0.23% | Put | |
| 47 | JW Asset Management, LLC | 98,775 | 1,253,000 | 0.23% | ||
| 48 | Point72 Asset Management, L.P. | 96,500 | 1,225,000 | 0.22% | ||
| 49 | WELLINGTON MANAGEMENT GROUP LLP | 89,640 | 1,138,000 | 0.21% | ||
| 50 | Jefferies Group LLC | 84,648 | 1,074,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
