| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,996,691 | 50,132,000 | 14.41% | ||
| 2 | Palo Alto Investors LP | 4,030,908 | 33,698,000 | 9.69% | ||
| 3 | PAULSON & CO. INC. | 3,927,000 | 32,830,000 | 9.44% | ||
| 4 | GREAT POINT PARTNERS LLC | 2,731,210 | 22,833,000 | 6.57% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 2,168,736 | 18,131,000 | 5.21% | ||
| 6 | STONEPINE CAPITAL MANAGEMENT, LLC | 2,068,297 | 17,291,000 | 4.97% | ||
| 7 | BlackRock Fund Advisors | 1,642,070 | 13,728,000 | 3.95% | ||
| 8 | ARMISTICE CAPITAL, LLC | 1,600,000 | 13,376,000 | 3.85% | ||
| 9 | VANGUARD GROUP INC | 1,596,278 | 13,346,000 | 3.84% | ||
| 10 | STATE STREET CORP | 1,488,367 | 12,442,000 | 3.58% | ||
| 11 | MORGAN STANLEY | 1,413,809 | 11,819,000 | 3.40% | ||
| 12 | MACQUARIE GROUP LTD | 1,229,942 | 10,282,000 | 2.96% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 1,093,279 | 9,140,000 | 2.63% | ||
| 14 | BANK OF MONTREAL /CAN/ | 1,087,319 | 9,090,000 | 2.61% | ||
| 15 | J. Goldman & Co LP | 871,000 | 7,282,000 | 2.09% | ||
| 16 | Avoro Capital Advisors LLC | 854,579 | 7,144,000 | 2.05% | ||
| 17 | NORTHERN TRUST CORP | 529,253 | 4,425,000 | 1.27% | ||
| 18 | SPHERA FUNDS MANAGEMENT LTD. | 512,051 | 4,281,000 | 1.23% | ||
| 19 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 464,568 | 3,884,000 | 1.12% | ||
| 20 | QS Investors, LLC | 447,733 | 3,743,000 | 1.08% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 416,900 | 3,485,000 | 1.00% | ||
| 22 | DEUTSCHE BANK AG\ | 412,819 | 3,450,000 | 0.99% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 379,671 | 3,173,000 | 0.91% | ||
| 24 | GOLDMAN SACHS GROUP INC | 312,906 | 2,616,000 | 0.75% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 300,179 | 2,510,000 | 0.72% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 211,246 | 1,766,000 | 0.51% | ||
| 27 | PRINCIPAL FINANCIAL GROUP INC | 208,500 | 1,743,000 | 0.50% | ||
| 28 | Bank of New York Mellon Corp | 199,244 | 1,665,000 | 0.48% | ||
| 29 | BlackRock Investment Management, LLC | 149,999 | 1,254,000 | 0.36% | ||
| 30 | CONVECTOR CAPITAL MANAGEMENT, LP | 132,000 | 1,104,000 | 0.32% | ||
| 31 | PDT Partners, LLC | 128,160 | 1,071,000 | 0.31% | ||
| 32 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 120,600 | 1,008,000 | 0.29% | ||
| 33 | COLUMBUS CIRCLE INVESTORS | 104,574 | 874,000 | 0.25% | ||
| 34 | CREDIT AGRICOLE S A | 100,784 | 843,000 | 0.24% | ||
| 35 | GOLDMAN SACHS GROUP INC | 93,300 | 780,000 | 0.22% | Call | |
| 36 | GOLDMAN SACHS GROUP INC | 93,200 | 779,000 | 0.22% | Put | |
| 37 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 88,844 | 743,000 | 0.21% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,586 | 741,000 | 0.21% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,900 | 735,000 | 0.21% | Call | |
| 40 | CREDIT SUISSE AG/ | 84,121 | 703,000 | 0.20% | ||
| 41 | FMR LLC | 78,200 | 654,000 | 0.19% | ||
| 42 | STRS OHIO | 76,627 | 640,000 | 0.18% | ||
| 43 | PERCEPTIVE ADVISORS LLC | 71,849 | 601,000 | 0.17% | ||
| 44 | OXFORD ASSET MANAGEMENT LLP | 69,999 | 585,000 | 0.17% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 69,400 | 580,000 | 0.17% | ||
| 46 | PURA VIDA INVESTMENTS, LLC | 67,500 | 564,000 | 0.16% | ||
| 47 | VIRTUS ETF ADVISERS LLC | 67,021 | 560,000 | 0.16% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,300 | 546,000 | 0.16% | Put | |
| 49 | Swiss National Bank | 66,700 | 538,000 | 0.15% | ||
| 50 | CITADEL ADVISORS LLC | 60,743 | 508,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
