| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,784,157 | 53,965,000 | 10.81% | ||
| 2 | Palo Alto Investors LP | 3,997,108 | 45,087,000 | 9.03% | ||
| 3 | PAULSON & CO. INC. | 3,946,500 | 44,517,000 | 8.92% | ||
| 4 | STATE STREET CORP | 2,488,179 | 28,066,000 | 5.62% | ||
| 5 | Avoro Capital Advisors LLC | 2,124,593 | 23,965,000 | 4.80% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,943,267 | 21,920,000 | 4.39% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,795,468 | 20,253,000 | 4.06% | ||
| 8 | GREAT POINT PARTNERS LLC | 1,715,000 | 19,345,000 | 3.88% | ||
| 9 | BlackRock Fund Advisors | 1,684,784 | 19,004,000 | 3.81% | ||
| 10 | MORGAN STANLEY | 1,572,900 | 17,742,000 | 3.56% | ||
| 11 | VANGUARD GROUP INC | 1,461,131 | 16,482,000 | 3.30% | ||
| 12 | Consonance Capital Management LP | 1,436,796 | 16,207,000 | 3.25% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 1,056,365 | 11,916,000 | 2.39% | ||
| 14 | MACQUARIE GROUP LTD | 1,007,058 | 11,360,000 | 2.28% | ||
| 15 | EverPoint Asset Management, LLC | 1,000,000 | 11,280,000 | 2.26% | ||
| 16 | BANK OF MONTREAL /CAN/ | 980,844 | 11,064,000 | 2.22% | ||
| 17 | Invesco Ltd. | 940,032 | 10,604,000 | 2.12% | ||
| 18 | ARMISTICE CAPITAL, LLC | 760,000 | 8,573,000 | 1.72% | ||
| 19 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 750,000 | 8,460,000 | 1.70% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 513,390 | 5,791,000 | 1.16% | ||
| 21 | J. Goldman & Co LP | 481,760 | 5,434,000 | 1.09% | ||
| 22 | NORTHERN TRUST CORP | 477,431 | 5,385,000 | 1.08% | ||
| 23 | DEUTSCHE BANK AG\ | 375,868 | 4,238,000 | 0.85% | ||
| 24 | ALPS ADVISORS INC | 36,344 | 4,100,000 | 0.82% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 310,700 | 3,505,000 | 0.70% | Call | |
| 26 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 300,000 | 3,384,000 | 0.68% | Call | |
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 281,471 | 3,174,000 | 0.64% | ||
| 28 | PDT Partners, LLC | 279,715 | 3,155,000 | 0.63% | ||
| 29 | J. Goldman & Co LP | 270,000 | 3,046,000 | 0.61% | Call | |
| 30 | PURA VIDA INVESTMENTS, LLC | 247,500 | 2,792,000 | 0.56% | ||
| 31 | PRINCIPAL FINANCIAL GROUP INC | 208,500 | 2,352,000 | 0.47% | ||
| 32 | Bank of New York Mellon Corp | 206,994 | 2,335,000 | 0.47% | ||
| 33 | QS Investors, LLC | 178,881 | 2,018,000 | 0.40% | ||
| 34 | MCKINLEY CAPITAL MANAGEMENT LLC | 171,973 | 1,940,000 | 0.39% | ||
| 35 | OXFORD ASSET MANAGEMENT LLP | 157,841 | 1,780,000 | 0.36% | ||
| 36 | BlackRock Investment Management, LLC | 150,409 | 1,697,000 | 0.34% | ||
| 37 | Iguana Healthcare Management, LLC | 150,000 | 1,692,000 | 0.34% | ||
| 38 | GOLDMAN SACHS GROUP INC | 136,530 | 1,540,000 | 0.31% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 134,546 | 1,518,000 | 0.30% | ||
| 40 | CITADEL ADVISORS LLC | 134,400 | 1,516,000 | 0.30% | ||
| 41 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 125,498 | 1,416,000 | 0.28% | ||
| 42 | TFS CAPITAL LLC | 121,934 | 1,375,000 | 0.28% | ||
| 43 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 118,707 | 1,339,000 | 0.27% | ||
| 44 | SG Americas Securities, LLC | 110,342 | 1,245,000 | 0.25% | ||
| 45 | Rotella Capital Management, Inc. | 109,800 | 1,239,000 | 0.25% | ||
| 46 | Cheyne Capital Management (UK) LLP | 109,000 | 1,228,000 | 0.25% | ||
| 47 | GOLDMAN SACHS GROUP INC | 107,300 | 1,210,000 | 0.24% | Put | |
| 48 | CREDIT AGRICOLE S A | 100,784 | 1,137,000 | 0.23% | ||
| 49 | Connor, Clark & Lunn Investment Management Ltd. | 89,900 | 1,014,000 | 0.20% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,800 | 1,013,000 | 0.20% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
