| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | CITIGROUP INC | 100 | 0 | 0.00% | ||
| 2 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 791 | 1,000 | 0.01% | ||
| 3 | ROYAL BANK OF CANADA | 1,378 | 2,000 | 0.01% | ||
| 4 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 5,192 | 8,000 | 0.06% | ||
| 5 | BARCLAYS PLC | 5,410 | 8,000 | 0.06% | ||
| 6 | BANK OF AMERICA CORP /DE/ | 8,575 | 13,000 | 0.09% | ||
| 7 | WELLS FARGO & COMPANY/MN | 9,162 | 14,000 | 0.10% | ||
| 8 | A.R.T. Advisors, LLC | 10,300 | 15,000 | 0.11% | ||
| 9 | COMERICA BANK | 10,331 | 16,000 | 0.11% | ||
| 10 | TWO SIGMA SECURITIES, LLC | 13,226 | 20,000 | 0.14% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 13,511 | 20,000 | 0.14% | ||
| 12 | CONNABLE OFFICE INC | 15,861 | 24,000 | 0.17% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,677 | 26,000 | 0.18% | ||
| 14 | MORGAN STANLEY | 18,535 | 28,000 | 0.20% | ||
| 15 | RAYMOND JAMES TRUST N.A. | 29,030 | 43,000 | 0.30% | ||
| 16 | WEDBUSH SECURITIES INC | 28,823 | 43,000 | 0.30% | ||
| 17 | JPMORGAN CHASE & CO | 31,515 | 47,000 | 0.33% | ||
| 18 | GOLDMAN SACHS GROUP INC | 39,901 | 59,000 | 0.41% | ||
| 19 | Minerva Advisors LLC | 46,909 | 70,000 | 0.49% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 49,000 | 73,000 | 0.51% | ||
| 21 | VHCP Management, LLC | 56,056 | 84,000 | 0.59% | ||
| 22 | Virtu KCG Holdings LLC | 58,204 | 87,000 | 0.61% | ||
| 23 | D. E. Shaw & Co., Inc. | 89,905 | 134,000 | 0.94% | ||
| 24 | VHCP MANAGEMENT II, LLC | 130,798 | 195,000 | 1.37% | ||
| 25 | FMR LLC | 197,100 | 294,000 | 2.06% | ||
| 26 | BAKER BROS. ADVISORS LP | 200,000 | 298,000 | 2.09% | ||
| 27 | GREENLEAF TRUST | 214,109 | 319,000 | 2.24% | ||
| 28 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 280,300 | 418,000 | 2.93% | ||
| 29 | AWM Investment Company, Inc. | 500,000 | 745,000 | 5.23% | ||
| 30 | PNC FINANCIAL SERVICES GROUP, INC. | 746,738 | 1,113,000 | 7.81% | ||
| 31 | SABBY MANAGEMENT, LLC | 940,841 | 1,402,000 | 9.84% | ||
| 32 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,166,619 | 1,738,000 | 12.20% | ||
| 33 | FRAZIER MANAGEMENT LLC | 2,186,195 | 3,257,000 | 22.86% | ||
| 34 | VIVO CAPITAL, LLC | 2,438,270 | 3,633,000 | 25.50% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
