| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,676,026 | 166,745,000 | 12.47% | ||
| 2 | NEA Management Company, LLC | 2,279,781 | 103,411,000 | 7.73% | ||
| 3 | OppenheimerFunds, Inc. | 1,777,384 | 80,623,000 | 6.03% | ||
| 4 | Palo Alto Investors LP | 1,721,757 | 78,099,000 | 5.84% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,443,400 | 65,473,000 | 4.90% | ||
| 6 | VANGUARD GROUP INC | 1,350,007 | 61,237,000 | 4.58% | ||
| 7 | PFM Health Sciences, LP | 1,270,209 | 57,617,000 | 4.31% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,268,251 | 57,528,000 | 4.30% | ||
| 9 | BlackRock Fund Advisors | 958,991 | 43,500,000 | 3.25% | ||
| 10 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 790,555 | 35,860,000 | 2.68% | ||
| 11 | Visium Asset Management, LP | 790,335 | 35,849,000 | 2.68% | ||
| 12 | Redmile Group, LLC | 784,459 | 35,583,000 | 2.66% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 746,516 | 33,862,000 | 2.53% | ||
| 14 | STATE STREET CORP | 707,769 | 32,108,000 | 2.40% | ||
| 15 | Pentwater Capital Management LP | 650,000 | 29,484,000 | 2.20% | ||
| 16 | BB BIOTECH AG | 558,188 | 25,319,000 | 1.89% | ||
| 17 | TimesSquare Capital Management, LLC | 464,820 | 21,084,000 | 1.58% | ||
| 18 | ArrowMark Colorado Holdings LLC | 391,146 | 17,742,000 | 1.33% | ||
| 19 | RUSSELL FRANK CO/ | 343,204 | 15,568,000 | 1.16% | ||
| 20 | SUFFOLK CAPITAL MANAGEMENT LLC | 342,318 | 15,528,000 | 1.16% | ||
| 21 | GOLDMAN SACHS GROUP INC | 338,336 | 15,347,000 | 1.15% | ||
| 22 | BLACKROCK ADVISORS LLC | 311,806 | 14,143,000 | 1.06% | ||
| 23 | NORTHERN TRUST CORP | 297,108 | 13,476,000 | 1.01% | ||
| 24 | TAMRO Capital Partners LLC | 277,509 | 12,588,000 | 0.94% | ||
| 25 | HIGHLAND CAPITAL MANAGEMENT LP | 265,000 | 12,020,000 | 0.90% | ||
| 26 | VOYA INVESTMENT MANAGEMENT LLC | 256,897 | 11,653,000 | 0.87% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226,300 | 10,265,000 | 0.77% | Call | |
| 28 | FARALLON CAPITAL MANAGEMENT LLC | 225,000 | 10,206,000 | 0.76% | ||
| 29 | CITADEL ADVISORS LLC | 205,063 | 9,302,000 | 0.70% | ||
| 30 | COLUMBUS CIRCLE INVESTORS | 190,346 | 8,634,000 | 0.65% | ||
| 31 | D. E. Shaw & Co., Inc. | 176,468 | 8,005,000 | 0.60% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 173,627 | 7,876,000 | 0.59% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 167,554 | 7,600,000 | 0.57% | ||
| 34 | BALYASNY ASSET MANAGEMENT L.P. | 166,176 | 7,538,000 | 0.56% | ||
| 35 | Invesco Ltd. | 152,753 | 6,929,000 | 0.52% | ||
| 36 | Bank of New York Mellon Corp | 138,097 | 6,264,000 | 0.47% | ||
| 37 | Opaleye Management Inc. | 140,000 | 6,210,400 | 0.46% | ||
| 38 | MORGAN STANLEY | 128,708 | 5,839,000 | 0.44% | ||
| 39 | CREDIT SUISSE AG/ | 126,581 | 5,743,000 | 0.43% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 126,306 | 5,729,000 | 0.43% | ||
| 41 | CQS Cayman LP | 125,000 | 5,670,000 | 0.42% | ||
| 42 | UBS AG | 121,579 | 5,515,000 | 0.41% | ||
| 43 | NORGES BANK | 107,751 | 4,888,000 | 0.37% | ||
| 44 | Tekla Capital Management LLC | 104,051 | 4,720,000 | 0.35% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,400 | 4,645,000 | 0.35% | Put | |
| 46 | SPHERA FUNDS MANAGEMENT LTD. | 101,955 | 4,625,000 | 0.35% | ||
| 47 | Corvex Management LP | 93,586 | 4,245,000 | 0.32% | ||
| 48 | BlackRock Investment Management, LLC | 86,451 | 3,921,000 | 0.29% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 85,187 | 3,864,000 | 0.29% | ||
| 50 | DEUTSCHE BANK AG\ | 83,883 | 3,803,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
