| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,619,195 | 318,055,000 | 11.21% | ||
| 2 | PFM Health Sciences, LP | 2,713,661 | 238,477,000 | 8.40% | ||
| 3 | Palo Alto Investors LP | 2,401,117 | 211,010,000 | 7.43% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,225,637 | 195,589,000 | 6.89% | ||
| 5 | VANGUARD GROUP INC | 1,799,421 | 158,133,000 | 5.57% | ||
| 6 | OppenheimerFunds, Inc. | 1,517,390 | 133,349,000 | 4.70% | ||
| 7 | NEA Management Company, LLC | 1,139,890 | 100,174,000 | 3.53% | ||
| 8 | BlackRock Fund Advisors | 1,039,109 | 91,317,000 | 3.22% | ||
| 9 | ORBIMED ADVISORS LLC | 1,005,200 | 88,337,000 | 3.11% | ||
| 10 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 826,919 | 72,670,000 | 2.56% | ||
| 11 | LORD, ABBETT & CO. LLC | 814,128 | 71,546,000 | 2.52% | ||
| 12 | Redmile Group, LLC | 759,479 | 66,743,000 | 2.35% | ||
| 13 | Visium Asset Management, LP | 750,823 | 65,983,000 | 2.32% | ||
| 14 | STATE STREET CORP | 705,543 | 62,004,000 | 2.18% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 690,801 | 60,708,000 | 2.14% | ||
| 16 | BB BIOTECH AG | 618,188 | 54,326,000 | 1.91% | ||
| 17 | TimesSquare Capital Management, LLC | 490,575 | 43,112,000 | 1.52% | ||
| 18 | CITADEL ADVISORS LLC | 482,661 | 42,416,000 | 1.49% | ||
| 19 | Versant Venture Management, LLC | 407,416 | 35,803,718 | 1.26% | ||
| 20 | JANUS HENDERSON INVESTORS US LLC | 330,929 | 29,082,000 | 1.02% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 319,400 | 28,069,000 | 0.99% | Call | |
| 22 | MORGAN STANLEY | 313,807 | 27,577,000 | 0.97% | ||
| 23 | Consonance Capital Management LP | 303,131 | 26,639,000 | 0.94% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 293,900 | 25,828,000 | 0.91% | Put | |
| 25 | NORTHERN TRUST CORP | 283,812 | 24,941,000 | 0.88% | ||
| 26 | PointState Capital LP | 255,000 | 22,409,000 | 0.79% | ||
| 27 | BLACKROCK ADVISORS LLC | 254,290 | 22,347,000 | 0.79% | ||
| 28 | SECTORAL ASSET MANAGEMENT INC | 246,952 | 21,702,000 | 0.76% | ||
| 29 | BAKER BROS. ADVISORS LP | 202,630 | 17,807,000 | 0.63% | ||
| 30 | JPMORGAN CHASE & CO | 197,300 | 17,339,000 | 0.61% | ||
| 31 | D. E. Shaw & Co., Inc. | 191,568 | 16,835,000 | 0.59% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 189,899 | 16,688,000 | 0.59% | ||
| 33 | Bank of New York Mellon Corp | 184,747 | 16,236,000 | 0.57% | ||
| 34 | DEUTSCHE BANK AG\ | 175,071 | 15,384,000 | 0.54% | ||
| 35 | NORGES BANK | 171,663 | 15,086,000 | 0.53% | ||
| 36 | Invesco Ltd. | 142,258 | 12,502,000 | 0.44% | ||
| 37 | CREDIT SUISSE AG/ | 140,427 | 12,341,000 | 0.43% | ||
| 38 | FRED ALGER MANAGEMENT, LLC | 136,024 | 11,954,000 | 0.42% | ||
| 39 | GOLDMAN SACHS GROUP INC | 123,009 | 10,810,000 | 0.38% | ||
| 40 | SPHERA FUNDS MANAGEMENT LTD. | 120,000 | 10,546,000 | 0.37% | ||
| 41 | Point72 Asset Management, L.P. | 117,100 | 10,291,000 | 0.36% | Put | |
| 42 | VOYA INVESTMENT MANAGEMENT LLC | 108,570 | 9,541,000 | 0.34% | ||
| 43 | GUGGENHEIM CAPITAL LLC | 104,476 | 9,181,000 | 0.32% | ||
| 44 | AMERIPRISE FINANCIAL INC | 103,358 | 9,083,000 | 0.32% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,537 | 8,747,000 | 0.31% | ||
| 46 | Allianz Asset Management GmbH | 99,215 | 8,719,000 | 0.31% | ||
| 47 | BlackRock Investment Management, LLC | 98,067 | 8,618,000 | 0.30% | ||
| 48 | TEACHERS ADVISORS, LLC | 97,371 | 8,557,000 | 0.30% | ||
| 49 | Hood River Capital Management LLC | 95,772 | 8,416,000 | 0.30% | ||
| 50 | Opaleye Management Inc. | 90,000 | 7,909,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
