| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Palo Alto Investors LP | 3,804,088 | 52,192,000 | 9.55% | ||
| 2 | Redmile Group, LLC | 3,097,850 | 42,503,000 | 7.77% | ||
| 3 | Consonance Capital Management LP | 2,936,487 | 40,289,000 | 7.37% | ||
| 4 | HealthCor Management, L.P. | 2,650,000 | 36,358,000 | 6.65% | ||
| 5 | VANGUARD GROUP INC | 2,405,468 | 33,003,000 | 6.04% | ||
| 6 | PointState Capital LP | 2,228,524 | 30,575,000 | 5.59% | ||
| 7 | PFM Health Sciences, LP | 1,986,582 | 27,256,000 | 4.98% | ||
| 8 | GOLDMAN SACHS GROUP INC | 1,750,327 | 24,014,000 | 4.39% | ||
| 9 | STATE STREET CORP | 1,635,355 | 22,436,000 | 4.10% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,520,794 | 20,865,000 | 3.82% | ||
| 11 | MORGAN STANLEY | 1,473,342 | 20,213,000 | 3.70% | ||
| 12 | BlackRock Fund Advisors | 1,274,534 | 17,487,000 | 3.20% | ||
| 13 | NEA Management Company, LLC | 1,139,890 | 15,639,000 | 2.86% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 823,036 | 11,292,000 | 2.07% | ||
| 15 | FMR LLC | 737,156 | 10,114,000 | 1.85% | ||
| 16 | SAMLYN CAPITAL, LLC | 678,410 | 9,308,000 | 1.70% | ||
| 17 | D. E. Shaw & Co., Inc. | 593,481 | 8,143,000 | 1.49% | ||
| 18 | Antipodean Advisors LLC | 523,000 | 7,176,000 | 1.31% | ||
| 19 | Ghost Tree Capital, LLC | 500,000 | 6,860,000 | 1.25% | Put | |
| 20 | BOXER CAPITAL, LLC | 450,000 | 6,174,000 | 1.13% | ||
| 21 | Ghost Tree Capital, LLC | 450,000 | 6,174,000 | 1.13% | ||
| 22 | Versant Venture Management, LLC | 407,416 | 5,589,748 | 1.02% | ||
| 23 | NORTHERN TRUST CORP | 390,230 | 5,353,000 | 0.98% | ||
| 24 | DEUTSCHE BANK AG\ | 372,673 | 5,111,000 | 0.93% | ||
| 25 | J. Goldman & Co LP | 336,200 | 4,613,000 | 0.84% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 316,600 | 4,344,000 | 0.79% | Call | |
| 27 | RENAISSANCE TECHNOLOGIES LLC | 307,200 | 4,215,000 | 0.77% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 297,099 | 4,076,000 | 0.75% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 277,500 | 3,807,000 | 0.70% | Put | |
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 227,024 | 3,114,000 | 0.57% | ||
| 31 | NORGES BANK | 222,573 | 3,054,000 | 0.56% | ||
| 32 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 2,744,000 | 0.50% | ||
| 33 | DEERFIELD MANAGEMENT COMPANY, L.P. | 169,506 | 2,326,000 | 0.43% | ||
| 34 | Bank of New York Mellon Corp | 164,735 | 2,260,000 | 0.41% | ||
| 35 | CASDIN CAPITAL, LLC | 150,000 | 2,058,000 | 0.38% | ||
| 36 | FOLGER HILL ASSET MANAGEMENT LP | 143,300 | 1,966,000 | 0.36% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 126,493 | 1,735,000 | 0.32% | ||
| 38 | Rock Springs Capital Management LP | 125,000 | 1,715,000 | 0.31% | ||
| 39 | CREDIT SUISSE AG/ | 122,697 | 1,682,000 | 0.31% | ||
| 40 | BlackRock Investment Management, LLC | 117,450 | 1,611,000 | 0.29% | ||
| 41 | GOLDMAN SACHS GROUP INC | 114,600 | 1,572,000 | 0.29% | Call | |
| 42 | UBS Group AG | 112,511 | 1,543,000 | 0.28% | ||
| 43 | Boston Partners | 112,211 | 1,540,000 | 0.28% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 105,186 | 1,444,000 | 0.26% | ||
| 45 | RICE HALL JAMES & ASSOCIATES, LLC | 94,594 | 1,298,000 | 0.24% | ||
| 46 | Iguana Healthcare Management, LLC | 90,000 | 1,235,000 | 0.23% | ||
| 47 | Jupiter Investment Management Ltd | 89,959 | 1,234,000 | 0.23% | ||
| 48 | JPMORGAN CHASE & CO | 79,299 | 1,088,000 | 0.20% | ||
| 49 | Jefferies Group LLC | 75,100 | 1,030,000 | 0.19% | Put | |
| 50 | BALYASNY ASSET MANAGEMENT L.P. | 75,000 | 1,029,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
