| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,084,935 | 352,233,000 | 18.57% | ||
| 2 | NEA Management Company, LLC | 2,279,781 | 157,920,000 | 8.32% | ||
| 3 | VANGUARD GROUP INC | 1,310,076 | 90,749,000 | 4.78% | ||
| 4 | Visium Asset Management, LP | 1,159,623 | 80,328,000 | 4.23% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,077,026 | 74,606,000 | 3.93% | ||
| 6 | PFM Health Sciences, LP | 1,076,820 | 74,591,000 | 3.93% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 943,970 | 65,389,000 | 3.45% | ||
| 8 | BlackRock Fund Advisors | 862,307 | 59,732,000 | 3.15% | ||
| 9 | OppenheimerFunds, Inc. | 850,602 | 58,921,000 | 3.11% | ||
| 10 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 790,555 | 54,761,000 | 2.89% | ||
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 675,000 | 46,757,000 | 2.46% | ||
| 12 | FRANKLIN RESOURCES INC | 629,400 | 43,599,000 | 2.30% | ||
| 13 | STATE STREET CORP | 533,333 | 36,948,000 | 1.95% | ||
| 14 | BAKER BROS. ADVISORS LP | 529,990 | 36,712,000 | 1.94% | ||
| 15 | D. E. Shaw & Co., Inc. | 519,385 | 35,978,000 | 1.90% | ||
| 16 | Redmile Group, LLC | 513,198 | 35,549,000 | 1.87% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 493,400 | 34,178,000 | 1.80% | ||
| 18 | BB BIOTECH AG | 488,188 | 33,817,000 | 1.78% | ||
| 19 | HealthCor Management, L.P. | 475,000 | 32,903,000 | 1.73% | ||
| 20 | SAC Capital Advisors LP | 458,238 | 31,742,000 | 1.67% | ||
| 21 | TimesSquare Capital Management, LLC | 429,650 | 29,762,000 | 1.57% | ||
| 22 | QVT Financial LP | 389,735 | 26,997,000 | 1.42% | ||
| 23 | ArrowMark Colorado Holdings LLC | 269,798 | 18,689,000 | 0.99% | ||
| 24 | NORTHERN TRUST CORP | 269,720 | 18,683,000 | 0.98% | ||
| 25 | JANUS HENDERSON INVESTORS US LLC | 251,789 | 17,441,000 | 0.92% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 247,008 | 17,110,000 | 0.90% | ||
| 27 | GOLDMAN SACHS GROUP INC | 228,418 | 15,822,000 | 0.83% | ||
| 28 | TAMRO Capital Partners LLC | 207,056 | 14,343,000 | 0.76% | ||
| 29 | Consonance Capital Management LP | 200,600 | 13,896,000 | 0.73% | ||
| 30 | Palo Alto Investors LP | 186,900 | 12,947,000 | 0.68% | ||
| 31 | PERCEPTIVE ADVISORS LLC | 172,217 | 11,929,000 | 0.63% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 164,200 | 11,375,000 | 0.60% | Call | |
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 157,209 | 10,889,000 | 0.57% | ||
| 34 | Invesco Ltd. | 156,760 | 10,859,000 | 0.57% | ||
| 35 | LORD, ABBETT & CO. LLC | 146,890 | 10,175,000 | 0.54% | ||
| 36 | VOYA INVESTMENT MANAGEMENT LLC | 130,415 | 9,034,000 | 0.48% | ||
| 37 | PointState Capital LP | 130,000 | 9,005,000 | 0.47% | ||
| 38 | TEACHERS ADVISORS, LLC | 124,398 | 8,617,000 | 0.45% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 123,700 | 8,569,000 | 0.45% | Put | |
| 40 | AMERIPRISE FINANCIAL INC | 122,542 | 8,488,000 | 0.45% | ||
| 41 | Cormorant Asset Management, LP | 120,000 | 8,312,000 | 0.44% | ||
| 42 | Pentwater Capital Management LP | 118,500 | 8,208,000 | 0.43% | ||
| 43 | Bank of New York Mellon Corp | 117,983 | 8,173,000 | 0.43% | ||
| 44 | JPMORGAN CHASE & CO | 108,739 | 7,532,000 | 0.40% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 91,618 | 6,346,000 | 0.33% | ||
| 46 | DENVER INVESTMENT ADVISORS LLC | 89,352 | 6,189,000 | 0.33% | ||
| 47 | Partner Investment Management, L.P. | 82,550 | 5,718,000 | 0.30% | ||
| 48 | SUFFOLK CAPITAL MANAGEMENT LLC | 76,200 | 5,278,000 | 0.28% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 73,932 | 5,121,000 | 0.27% | ||
| 50 | CREDIT SUISSE AG/ | 72,289 | 5,006,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
