| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,148,445 | 307,939,000 | 12.55% | ||
| 2 | NEA Management Company, LLC | 2,279,781 | 169,228,000 | 6.89% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,275,482 | 168,909,000 | 6.88% | ||
| 4 | PFM Health Sciences, LP | 2,266,756 | 168,261,000 | 6.85% | ||
| 5 | Palo Alto Investors LP | 2,121,857 | 157,505,000 | 6.42% | ||
| 6 | VANGUARD GROUP INC | 1,647,649 | 122,305,000 | 4.98% | ||
| 7 | OppenheimerFunds, Inc. | 1,497,250 | 111,141,000 | 4.53% | ||
| 8 | BlackRock Fund Advisors | 1,066,240 | 79,147,000 | 3.22% | ||
| 9 | ORBIMED ADVISORS LLC | 1,000,400 | 74,260,000 | 3.03% | ||
| 10 | Redmile Group, LLC | 900,879 | 66,872,000 | 2.72% | ||
| 11 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 826,919 | 61,383,000 | 2.50% | ||
| 12 | Versant Venture Management, LLC | 814,833 | 60,485,054 | 2.46% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 719,622 | 53,418,000 | 2.18% | ||
| 14 | STATE STREET CORP | 678,586 | 50,370,000 | 2.05% | ||
| 15 | Visium Asset Management, LP | 656,992 | 48,768,000 | 1.99% | ||
| 16 | BB BIOTECH AG | 618,188 | 45,888,000 | 1.87% | ||
| 17 | LORD, ABBETT & CO. LLC | 571,080 | 42,391,000 | 1.73% | ||
| 18 | TimesSquare Capital Management, LLC | 496,920 | 36,886,000 | 1.50% | ||
| 19 | JANUS HENDERSON INVESTORS US LLC | 328,253 | 24,366,000 | 0.99% | ||
| 20 | MORGAN STANLEY | 321,706 | 23,880,000 | 0.97% | ||
| 21 | NORTHERN TRUST CORP | 292,785 | 21,733,000 | 0.89% | ||
| 22 | ArrowMark Colorado Holdings LLC | 280,846 | 20,847,000 | 0.85% | ||
| 23 | AMERIPRISE FINANCIAL INC | 259,052 | 19,230,000 | 0.78% | ||
| 24 | SECTORAL ASSET MANAGEMENT INC | 249,152 | 18,495,000 | 0.75% | ||
| 25 | EcoR1 Capital, LLC | 243,048 | 18,041,000 | 0.73% | ||
| 26 | BLACKROCK ADVISORS LLC | 227,799 | 16,909,000 | 0.69% | ||
| 27 | BALYASNY ASSET MANAGEMENT L.P. | 217,414 | 16,139,000 | 0.66% | ||
| 28 | BAKER BROS. ADVISORS LP | 202,630 | 15,041,000 | 0.61% | ||
| 29 | PointState Capital LP | 200,000 | 14,846,000 | 0.60% | ||
| 30 | UBS Group AG | 199,563 | 14,814,000 | 0.60% | ||
| 31 | Allianz Asset Management GmbH | 198,910 | 14,765,000 | 0.60% | ||
| 32 | JPMORGAN CHASE & CO | 193,065 | 14,332,000 | 0.58% | ||
| 33 | RUSSELL FRANK CO/ | 192,721 | 14,306,000 | 0.58% | ||
| 34 | SUFFOLK CAPITAL MANAGEMENT LLC | 186,642 | 13,854,000 | 0.56% | ||
| 35 | CITADEL ADVISORS LLC | 183,797 | 13,643,000 | 0.56% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 183,350 | 13,610,000 | 0.55% | ||
| 37 | VOYA INVESTMENT MANAGEMENT LLC | 172,248 | 12,785,000 | 0.52% | ||
| 38 | NORGES BANK | 171,663 | 12,743,000 | 0.52% | ||
| 39 | D. E. Shaw & Co., Inc. | 167,358 | 12,423,000 | 0.51% | ||
| 40 | Bank of New York Mellon Corp | 160,738 | 11,932,000 | 0.49% | ||
| 41 | FRED ALGER MANAGEMENT, LLC | 154,119 | 11,440,000 | 0.47% | ||
| 42 | CREDIT SUISSE AG/ | 150,509 | 11,173,000 | 0.46% | ||
| 43 | TAMRO Capital Partners LLC | 144,261 | 10,708,000 | 0.44% | ||
| 44 | Opaleye Management Inc. | 140,000 | 10,392,000 | 0.42% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 140,000 | 10,392,000 | 0.42% | Call | |
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,800 | 9,338,000 | 0.38% | Put | |
| 47 | SPHERA FUNDS MANAGEMENT LTD. | 112,455 | 8,348,000 | 0.34% | ||
| 48 | Invesco Ltd. | 106,720 | 7,922,000 | 0.32% | ||
| 49 | Point72 Asset Management, L.P. | 100,000 | 7,423,000 | 0.30% | Put | |
| 50 | TIAA CREF INVESTMENT MANAGEMENT LLC | 98,291 | 7,296,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
