| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,859,599 | 216,138,000 | 11.38% | ||
| 2 | NEA Management Company, LLC | 2,279,781 | 127,668,000 | 6.72% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,213,404 | 123,951,000 | 6.52% | ||
| 4 | Palo Alto Investors LP | 2,102,857 | 117,760,000 | 6.20% | ||
| 5 | OppenheimerFunds, Inc. | 1,776,974 | 99,510,000 | 5.24% | ||
| 6 | PFM Health Sciences, LP | 1,725,126 | 96,607,000 | 5.08% | ||
| 7 | VANGUARD GROUP INC | 1,397,792 | 78,277,000 | 4.12% | ||
| 8 | Versant Venture Management, LLC | 814,833 | 60,485,054 | 3.18% | ||
| 9 | BlackRock Fund Advisors | 1,039,661 | 58,221,000 | 3.06% | ||
| 10 | Visium Asset Management, LP | 927,839 | 51,961,000 | 2.73% | ||
| 11 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 790,555 | 44,271,000 | 2.33% | ||
| 12 | Redmile Group, LLC | 721,632 | 40,411,000 | 2.13% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 715,720 | 40,080,000 | 2.11% | ||
| 14 | ORBIMED ADVISORS LLC | 714,100 | 39,990,000 | 2.10% | ||
| 15 | STATE STREET CORP | 693,094 | 38,811,000 | 2.04% | ||
| 16 | BB BIOTECH AG | 618,188 | 34,619,000 | 1.82% | ||
| 17 | LORD, ABBETT & CO. LLC | 554,395 | 31,046,000 | 1.63% | ||
| 18 | JANUS HENDERSON INVESTORS US LLC | 504,123 | 28,231,000 | 1.49% | ||
| 19 | Pentwater Capital Management LP | 494,600 | 27,698,000 | 1.46% | ||
| 20 | TimesSquare Capital Management, LLC | 489,620 | 27,419,000 | 1.44% | ||
| 21 | AMERIPRISE FINANCIAL INC | 437,509 | 24,499,000 | 1.29% | ||
| 22 | SECTORAL ASSET MANAGEMENT INC | 423,452 | 23,713,000 | 1.25% | ||
| 23 | ArrowMark Colorado Holdings LLC | 412,857 | 23,120,000 | 1.22% | ||
| 24 | RUSSELL FRANK CO/ | 416,421 | 22,966,000 | 1.21% | ||
| 25 | MORGAN STANLEY | 394,247 | 22,077,000 | 1.16% | ||
| 26 | EcoR1 Capital, LLC | 384,348 | 21,523,000 | 1.13% | ||
| 27 | GOLDMAN SACHS GROUP INC | 343,740 | 19,249,000 | 1.01% | ||
| 28 | SUFFOLK CAPITAL MANAGEMENT LLC | 339,327 | 19,002,000 | 1.00% | ||
| 29 | BLACKROCK ADVISORS LLC | 313,262 | 17,542,000 | 0.92% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 302,900 | 16,962,000 | 0.89% | Call | |
| 31 | NORTHERN TRUST CORP | 288,231 | 16,141,000 | 0.85% | ||
| 32 | UBS Group AG | 247,739 | 13,873,000 | 0.73% | ||
| 33 | VOYA INVESTMENT MANAGEMENT LLC | 238,472 | 13,354,000 | 0.70% | ||
| 34 | BAKER BROS. ADVISORS LP | 202,630 | 11,347,000 | 0.60% | ||
| 35 | Allianz Asset Management GmbH | 199,225 | 11,157,000 | 0.59% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 173,699 | 9,727,000 | 0.51% | ||
| 37 | JPMORGAN CHASE & CO | 172,622 | 9,666,000 | 0.51% | ||
| 38 | D. E. Shaw & Co., Inc. | 169,149 | 9,472,000 | 0.50% | ||
| 39 | Invesco Ltd. | 168,631 | 9,443,000 | 0.50% | ||
| 40 | NORGES BANK | 156,861 | 8,784,000 | 0.46% | ||
| 41 | TAMRO Capital Partners LLC | 154,154 | 8,633,000 | 0.45% | ||
| 42 | Bank of New York Mellon Corp | 151,135 | 8,464,000 | 0.45% | ||
| 43 | Opaleye Management Inc. | 140,000 | 7,840,000 | 0.41% | ||
| 44 | CREDIT SUISSE AG/ | 129,533 | 7,253,000 | 0.38% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 127,000 | 7,112,000 | 0.37% | Put | |
| 46 | CITADEL ADVISORS LLC | 113,496 | 6,356,000 | 0.33% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,266 | 6,119,000 | 0.32% | ||
| 48 | Candriam S.C.A. | 109,000 | 6,104,000 | 0.32% | ||
| 49 | CQS Cayman LP | 105,000 | 5,880,000 | 0.31% | ||
| 50 | Hood River Capital Management LLC | 100,000 | 5,600,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
