| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,434,675 | 315,853,000 | 9.28% | ||
| 2 | Palo Alto Investors LP | 3,108,808 | 285,886,000 | 8.40% | ||
| 3 | PFM Health Sciences, LP | 2,552,887 | 234,763,000 | 6.90% | ||
| 4 | VANGUARD GROUP INC | 2,063,936 | 189,800,000 | 5.58% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,936,873 | 178,115,000 | 5.23% | ||
| 6 | OppenheimerFunds, Inc. | 1,347,810 | 123,944,000 | 3.64% | ||
| 7 | Antipodean Advisors LLC | 1,306,491 | 120,145,000 | 3.53% | ||
| 8 | BlackRock Fund Advisors | 1,235,880 | 113,652,000 | 3.34% | ||
| 9 | NEA Management Company, LLC | 1,139,890 | 104,824,000 | 3.08% | ||
| 10 | ORBIMED ADVISORS LLC | 1,105,900 | 101,699,000 | 2.99% | ||
| 11 | Redmile Group, LLC | 957,634 | 88,064,000 | 2.59% | ||
| 12 | CLIFTON PARK CAPITAL MANAGEMENT, LLC | 882,891 | 81,190,000 | 2.39% | ||
| 13 | VIKING GLOBAL INVESTORS LP | 836,332 | 76,909,000 | 2.26% | ||
| 14 | Visium Asset Management, LP | 781,778 | 71,893,000 | 2.11% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 756,580 | 69,575,000 | 2.04% | ||
| 16 | STATE STREET CORP | 731,429 | 67,263,000 | 1.98% | ||
| 17 | WELLS FARGO & COMPANY/MN | 635,574 | 58,447,000 | 1.72% | ||
| 18 | CITADEL ADVISORS LLC | 631,943 | 58,113,000 | 1.71% | ||
| 19 | BB BIOTECH AG | 618,188 | 56,849,000 | 1.67% | ||
| 20 | ALPS ADVISORS INC | 58,835 | 54,105,000 | 1.59% | ||
| 21 | BALYASNY ASSET MANAGEMENT L.P. | 483,281 | 44,443,000 | 1.31% | ||
| 22 | TimesSquare Capital Management, LLC | 418,980 | 38,529,000 | 1.13% | ||
| 23 | Versant Venture Management, LLC | 407,416 | 37,465,975 | 1.10% | ||
| 24 | D. E. Shaw & Co., Inc. | 347,304 | 31,938,000 | 0.94% | ||
| 25 | NORTHERN TRUST CORP | 325,497 | 29,933,000 | 0.88% | ||
| 26 | MORGAN STANLEY | 325,075 | 29,894,000 | 0.88% | ||
| 27 | JANUS HENDERSON INVESTORS US LLC | 317,359 | 29,184,000 | 0.86% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 297,805 | 27,386,000 | 0.80% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 275,100 | 25,298,000 | 0.74% | Call | |
| 30 | BLACKROCK ADVISORS LLC | 262,626 | 24,151,000 | 0.71% | ||
| 31 | LORD, ABBETT & CO. LLC | 233,469 | 21,470,000 | 0.63% | ||
| 32 | NORGES BANK | 222,573 | 20,468,000 | 0.60% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 220,716 | 20,297,000 | 0.60% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 210,300 | 19,339,000 | 0.57% | Put | |
| 35 | DEUTSCHE BANK AG\ | 206,758 | 19,012,000 | 0.56% | ||
| 36 | BAKER BROS. ADVISORS LP | 202,630 | 18,634,000 | 0.55% | ||
| 37 | Invesco Ltd. | 187,422 | 17,236,000 | 0.51% | ||
| 38 | Bank of New York Mellon Corp | 186,051 | 17,109,000 | 0.50% | ||
| 39 | Allianz Asset Management GmbH | 163,310 | 15,018,000 | 0.44% | ||
| 40 | Neuberger Berman Group LLC | 160,959 | 14,802,000 | 0.43% | ||
| 41 | JPMORGAN CHASE & CO | 158,264 | 14,553,000 | 0.43% | ||
| 42 | VOYA INVESTMENT MANAGEMENT LLC | 141,445 | 13,007,000 | 0.38% | ||
| 43 | RENAISSANCE TECHNOLOGIES LLC | 128,900 | 11,854,000 | 0.35% | ||
| 44 | AMERIPRISE FINANCIAL INC | 127,484 | 11,723,000 | 0.34% | ||
| 45 | Point72 Asset Management, L.P. | 117,100 | 10,769,000 | 0.32% | Put | |
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 112,211 | 10,319,000 | 0.30% | ||
| 47 | BlackRock Investment Management, LLC | 107,076 | 9,847,000 | 0.29% | ||
| 48 | SPHERA FUNDS MANAGEMENT LTD. | 105,000 | 9,656,000 | 0.28% | ||
| 49 | FRED ALGER MANAGEMENT, LLC | 104,991 | 9,655,000 | 0.28% | ||
| 50 | CREDIT SUISSE AG/ | 104,781 | 9,635,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
